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Your Position: Casa > Familias de proteínas interleucinas

Familias de proteínas interleucinas

Interleukin Protein Families
Introducción
HOT PRODUCTS
FAMILY INVENTORY
SUPPLEMENTAL DATA
Introducción

Interleucinas (IL) es un término que describe un grupo de moléculas secretadas producidas por los leucocitos que actúan sobre diversas células. En general, las IL se clasifican como citoquinas, pero también pertenecen a la familia de las linfoquinas. Las IL tienen diversas funciones biológicas; no sólo intervienen en la regulación de la respuesta inmunitaria, como la promoción de la transmisión de información, la activación y la regulación de las células inmunitarias, sino que también participan ampliamente en la regulación de los procesos fisiológicos y patológicos del organismo, como las enfermedades autoinmunitarias, inflamatorias y tumorales. Basándose en la homología estructural de las citocinas, las interleucinas se dividen en varias familias de proteínas, como las familias IL-1, IL-2, IL-6, IL-10, IL-12 e IL-17.

Cabe señalar que, la familia de las interleucinas se ha convertido en un importante objetivo farmacológico, muchas de las cuales ya se comercializan e incluso ocupan una importante cuota de mercado de fármacos para enfermedades similares.

Data from Pharmacodia
Data from Pharmacodia
Data from Pharmacodia
Productos más populares

Familias de interleucinas y proteínas relacionadas
Familia IL-1
Familia IL-1
IL-1 alphaIL-1 betaIL-1 RAcPIL-1 RIIIL-1 Rrp2IL-1RL1IL-18IL-18 R betaIL-18 R1IL-18BPIL-33IL-37IL-38
Familia IL-2
Familia IL-2
IL-2IL-2 R alphaIL-2 R betaIL-2 R gammaIL-2 R beta & IL-2 R gammaIL-2 R beta & IL-2 R alpha & IL-2 R gammaIL-4IL-4 R alphaIL-7IL-7 R alphaIL-7-P2AIL-13IL-13 R alpha 1IL-13 R alpha 2IL-15IL-15 R alphaIL-21 IL-21 R
Familia IL-6
Familia IL-6
IL-6IL-6 R alphagp130IL-11IL-11 R alphaIL-31IL-31 RA
Familia IL-10
Familia IL-10
IL-10IL-10 R alphaIL-20IL-20 R alphaIL-22IL-26IL-29
Familia IL-17
Familia IL-17
IL-17AIL-17BIL-17CIL-17EIL-17FIL-17A & IL-17FIL-17 RAIL-17 RCIL-17 RA & IL-17 RCIL-17 RE
Otras moléculas
IL-5IL-5 R alphaIL-3IL-3 R alphIL-8
Datos complementarios
Alta pureza y alta homogeneidad estructural verificada por SDS-PAGE y SEC-MALS
ILR-H5253

Biotinylated Human IL-1 RAcP, His,Avitag (Cat. No. ILP-H82E5) on SDS-PAGE under reducing (R) condition. The purity of the protein is greater than 90%. As verified by SEC-MALS, the purity is more than 90% and the molecular weight of this protein is around 50-68 kDa.

IL4-C5259

Human IL-2RB&IL-2RA&IL-2RG, Fc Tag&Fc Tag (Cat. No. ILG-H5257) on SDS-PAGE under reducing (R) condition. The purity of the protein is greater than 95%. As verified by SEC-MALS, the purity is more than 90% and the molecular weight of this protein is around 160-190 kDa.

Alta actividad biológica verificada por ELISA
High purity and structural homogeneity verified by SDS-PAGE and SEC-MALS

Immobilized Mouse IL-2, His Tag (Cat. No. IL2-M52H3) at 5 μg/mL (100 μL/well) can bind Mouse IL-2RB&IL-2RA&IL-2RG, Fc Tag&Fc Tag (Cat. No. ILG-M5253) with a linear range of 0.8-3 ng/mL (QC tested).


High purity and structural homogeneity verified by SDS-PAGE and SEC-MALS

Immobilized Human IL-4 R alpha, Fc Tag (Cat. No. ILR-H5253) at 5 μg/mL (100 μL/well) can bind Biotinylated Human IL-4, Avitag,His Tag (Cat. No. IL4-H82E0) with a linear range of 0.1-2 ng/mL (Routinely tested).

Afinidad verificada por SPR y BLI
High purity and structural homogeneity verified by SDS-PAGE and SEC-MALS

Human IL-31, His Tag (Cat. No. IL1-H5247) capture on NTA-Series S sensor chip can bind Human IL-31 RA, Fc Tag (Cat. No. ILA-H5256) with an affinity constant of 37.1 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

High purity and structural homogeneity verified by SDS-PAGE and SEC-MALS

Human IL-13 R alpha 1 Protein, His Tag (Cat. No. IL1-H5224) captured on CM5 chip via anti-His antibody can bind Human IL-13 with an affinity constant of 16 nM as determined in a SPR assay (Biacore T200) (QC tested).

High purity and structural homogeneity verified by SDS-PAGE and SEC-MALS

Loaded Biotinylated Human IL-6, epitope tag free, primary amine labeling (Cat. No. IL6-H8218) on SA Biosensor, can bind Human IL-6 R alpha, His Tag (Cat. No. ILR-H4223) with an affinity constant of 45.9 nM as determined in BLI assay (ForteBio Octet Red96e).

High purity and structural homogeneity verified by SDS-PAGE and SEC-MALS

Loaded Biotinylated Human IL17A, His,Avitag (Cat. No. ILA-H82Q1) on SA Biosensor, can bind Human IL-17 RA, His Tag (Cat. No. ILA-H5222) with an affinity constant of 18.8 nM as determined in BLI assay (ForteBio Octet Red96e).

Referencias
  • 1. Chung S H, Ye X Q, Iwakura Y. Interleukin-17 family members in health and disease[J]. International immunology, 2021, 33(12): 723-729. https://doi.org/10.1093/intimm/dxab075.
  • 2. Wojno E D T, Hunter C A, Stumhofer J S. The immunobiology of the interleukin-12 family: room for discovery[J]. Immunity, 2019, 50(4): 851-870. https://doi.org/10.1016/j.immuni.2019.03.011.
  • 3. Rose-John S. Interleukin-6 family cytokines[J]. Cold Spring Harbor perspectives in biology, 2018, 10(2): a028415. https://doi.org/10.1101/cshperspect.a028415.
  • 4. Netea M G, van de Veerdonk F L, van der Meer J W M, et al. Inflammasome-independent regulation of IL-1-family cytokines[J]. Annual review of immunology, 2015, 33: 49-77. https://doi.org/10.1146/annurev-immunol-032414-112306.
  • 5. Zdanov A. Structural analysis of cytokines comprising the IL-10 family[J]. Cytokine & growth factor reviews, 2010, 21(5): 325-330.doi:10.1016/j.cytogfr.2010.08.003.
  • 6. Dumont F J. Interleukin-2 family cytokines: potential for therapeutic immmunoregulation[J]. Expert Opinion on Therapeutic Patents, 2005, 15(5): 521-554. https://doi.org/10.1517/13543776.15.5.521.
  • 7. Fickenscher H, Hör S, Küpers H, et al. The interleukin-10 family of cytokines[J]. Trends in immunology, 2002, 23(2): 89-96. https://doi.org/10.1016/S1471-4906(01)02149-4.
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