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Mogengel Matrix Basement Membrane Extracts

Mogengel Matrix Basement Membrane Extracts
Mogengel Matrix
Basement Membrane Extracts
ACROBiosystems, through Acro Certify, is pleased to now offer a wide selection of Mogengel basement membrane extracts. Different versions – including phenol red-free, high concentration, iPSC culturing, organoid culturing – are all available for your specific needs!
Validated by Cellular Function Assays
Validated by Cellular Function Assays

Strict application-oriented quality control assays established for every produced lot, including tumorigenesis, angiogenesis, and tumor cell invasion.

Lot-to-Lot Consistency
Lot-to-Lot Consistency

Strict manufacturing controls and management systems including endotoxin, viral, and bacterial tests to ensure product consistency and quality.

Stable, Long-term Supply
Stable, Long-term Supply

Large-scale manufacturing capacity paired with ACROBiosystems’ global supply chain to stabilize supply across the globe.

Cost Effective Reagents
Cost Effective Reagents

Bulk pricing and growth factor bundle discounts to meet your research needs.

Mogengel Matrix products undergo extensive testing to ensure its quality and consistency when it comes into your hands and takes advantage of ACROBiosystems’ worldwide warehouses to deliver it quickly, and without delay.

Mogengel Matrix
Supporting 2-D and 3-D Cell Culture with Mogengel

Mogengel Matrix is a soluble form of basement membrane matrix that is purified from gene-edited mouse tumor cells grown in a LDEV-free mouse population and is comprised of laminin, collagen IV, entactin, and heparin sulfate proteoglycan.

Basement membranes form continuous sheets of a specialized extracellular matrix that are an essential part in the organization of tissues forming the scaffolding and support for cellular growth and cell layers. They also affect a variety of cellular mechanisms such as adhesion, migration, proliferation, and differentiation.

Supporting 2-D and 3-D Cell Culture with Mogengel
Various BME Versions for Specific Applications
To better match your research applications, various forms of Mogengel Matrix, basement membrane extracts, are available including phenol red-free versions, with specified applications. Explore the various products for your specific application below, or look at our product list.
Mogengel Matrix
(Standard)
Mogengel Matrix
Designed for 2-D and 3-D cell culturing, including cell proliferation, differentiation, and organoid culturing. This includes assays such as cell invasion, angiogenesis, and organoid culture.
Mogengel Matrix GFR
(Growth Factor Reduced)
Mogengel Matrix GFR
Designed for organoid and 3-D cell culturing. Also used for applications requiring extracellular matrix scaffolding, or more demanding applications such as tubular osteocyte signaling or mouse mammalian epithelial expression studies.
Mogengel Matrix HC
(High Concentration)
Mogengel Matrix HC
Designed for in vivo experiments, including patient-derived xenografts, cell-derived xenografts, as well as in vitro angiogenesis assays.
Mogengel Matrix iPSC Level
(Stem Cell)
Mogengel Matrix iPSC Level
Designed as a supplement for specified media to culture stem cells including human embryonic stem cells and induced pluripotent stem cells (iPSCs).
Mogengel Matrix Organoid Culture
(Organoid)
Mogengel Matrix Organoid Culture
Designed for robust, reproducible culturing of hard-to-culture organoids including mouse intestinal, lung, and human brain organoids.
Product List
Cat. No. Product Type Product Description Size
AC-M082704 Standard Mogengel Matrix (Acro Certified) 10mL/5mL
AC-M082706 Mogengel Matrix (Phenol Red Free) (Acro Certified) 10mL/5mL
AC-M082701 Low-factor Mogengel Matrix (GFR) (Acro Certified) 10mL/5mL
AC-M082703 Mogengel Matrix (GFR Phenol Red Free) (Acro Certified) 10mL/5mL
AC-M082724 High Concentration Mogengel Matrix (HC) (Acro Certified) 10mL/5mL
AC-M082726 Mogengel Matrix (HC Phenol Red Free) (Acro Certified) 10mL/5mL
AC-M082721 Mogengel Matrix (HC GFR) (Acro Certified) 10mL/5mL
AC-M082723 Mogengel Matrix (HC GFR Phenol Red Free) (Acro Certified) 10mL/5mL
AC-M082777 Stem Cell Mogengel Matrix IPSC Level (Acro Certified) 10mL/5mL
AC-M082755 Organoid Mogengel Matrix Organoid Culture (Acro Certified) 10mL/5mL
Supplementary Data by Application
  • iPSC Culturing

  • Organoid Culturing

  • Tumor Cell Invasion

  • Tumorigenesis Assay

  • Angiogenesis Assay

iPSC Culturing

iPSC Culturing

Mogengel (Cat. No. AC-M082777) 1:100 dilution coating the plates, supports stable passage of EPSCs (extended pluripotent stem cells) from P1 to P4.

Organoid Culturing

Organoid Culturing

Human tumor organoids (colorectal cancer organoids, gastric cancer organoids) can grow well in greater than 70% Mogengel (Cat. No. AC-M082755).

Organoid Culturing

Human tumor organoids (breast cancer organoids, hepatocellular carcinoma organoids) can grow well in greater than 70% Mogengel (Cat. No. AC-M082703).

Organoid Culturing

Mouse intestinal organoid, liver ductal organoid, airway organoid can also grow well in greater than 70% Mogengel (Cat. No. AC-M082703).

Tumor Cell Invasion

Tumor Cell Invasion

The invasion effect of 5×104 SGC-7901 was detected for 24 hours at different concentrations of Mogengel (Cat. No. AC-M082704) and it was clear that the number of successfully invaded cells decreased significantly as the concentration of Mogengel increased.

Tumor Cell Invasion

The invasion effect of 5×104 SGC-7901 was detected for 24 hours at different concentrations of Mogengel (Cat. No. AC-M082706) and it was clear that the number of successfully invaded cells decreased significantly as the concentration of Mogengel increased.

Tumorigenesis Assay

Tumorigenesis Assay

Mogengel (Cat. No. AC-M082724) significantly promotes the proliferation of tumor cells under the skin in nude mice.

Angiogenesis Assay

Angiogenesis Assay

The complete medium and HUVECs suspension (2×104 /well in 96 wells) can form the excellent tubular structure on 100% and 67% Mogengel Matrix (Cat. No. AC-M082704) at 4h, which can be quickly performed for subsequent staining and angiogenesis analysis.

Angiogenesis Assay

The complete medium and HUVECs suspension (2×104 /well in 96 wells) can form the excellent tubular structure on 100% and 67% Mogengel Matrix (Cat. No. AC-M082706) at 4h, which can be quickly performed for subsequent staining and angiogenesis analysis.

Angiogenesis Assay

VEGF and Heparin could promote the in vivo angiogenesis through in vivo Mogengel plug assay. (Cat. No. AC-M082723).

iPSC Culturing

iPSC Culturing

Mogengel (Cat. No. AC-M082777) 1:100 dilution coating the plates, supports stable passage of EPSCs (extended pluripotent stem cells) from P1 to P4.

Organoid Culturing

Organoid Culturing

Human tumor organoids (colorectal cancer organoids, gastric cancer organoids) can grow well in greater than 70% Mogengel (Cat. No. AC-M082755).

Organoid Culturing

Human tumor organoids (breast cancer organoids, hepatocellular carcinoma organoids) can grow well in greater than 70% Mogengel (Cat. No. AC-M082703).

Organoid Culturing

Mouse intestinal organoid, liver ductal organoid, airway organoid can also grow well in greater than 70% Mogengel (Cat. No. AC-M082703).

Tumor Cell Invasion

Tumor Cell Invasion

The invasion effect of 5×104 SGC-7901 was detected for 24 hours at different concentrations of Mogengel (Cat. No. AC-M082704) and it was clear that the number of successfully invaded cells decreased significantly as the concentration of Mogengel increased.

Tumor Cell Invasion

The invasion effect of 5×104 SGC-7901 was detected for 24 hours at different concentrations of Mogengel (Cat. No. AC-M082706) and it was clear that the number of successfully invaded cells decreased significantly as the concentration of Mogengel increased.

Tumorigenesis Assay

Tumorigenesis Assay

Mogengel (Cat. No. AC-M082724) significantly promotes the proliferation of tumor cells under the skin in nude mice.

Angiogenesis Assay

Angiogenesis Assay

The complete medium and HUVECs suspension (2×104 /well in 96 wells) can form the excellent tubular structure on 100% and 67% Mogengel Matrix (Cat. No. AC-M082704) at 4h, which can be quickly performed for subsequent staining and angiogenesis analysis.

Angiogenesis Assay

The complete medium and HUVECs suspension (2×104 /well in 96 wells) can form the excellent tubular structure on 100% and 67% Mogengel Matrix (Cat. No. AC-M082706) at 4h, which can be quickly performed for subsequent staining and angiogenesis analysis.

Angiogenesis Assay

VEGF and Heparin could promote the in vivo angiogenesis through in vivo Mogengel plug assay. (Cat. No. AC-M082723).

More Comprehensive Solutions at ACROBiosystems: Cytokines for Organoid Culture
Looking to further optimize your organoid culturing with Mogengel? With organoids becoming an essential preclinical model for disease research and drug development, ACROBiosystems offers a series of high-quality Activemax (R) cytokines, including EGF, Noggin, R-Spondin 1, FGF10, FGF2, and Activin A. Explore our catalog of growth factors to support your organoid growth along with Mogengel Matrix.
 
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Acro Certify Disclaimer
This product is one of ACROBiosystems’ Acro Certify products. ACROBiosystems and our Acro Certify partners have established a close partnership that includes an in-depth review of quality management and quality audits this product. Products from our Acro Certify partners have been qualified by ACROBiosystems to be included under Acro Certify. ACROBiosystems may provide Product information, including technical information, specifications, recommendations, literature, and other material (collectively, “Product Information”) for customer’s convenience. The accuracy and completeness of Product Information is not guaranteed and is subject to change without notice. ACROBiosystems is not responsible for the intellectual property or impact to intellectual property for products sold under Acro Certify.

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