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Explore our series of high-quality proteins covering comprehensive diagnostic indicators in order to facilitate the in vitro diagnostic research of neurological diseases.
Pre-formed fibrils are an invaluable preclinical model for exploring pathogenesis of neurological diseases through aggregation of misfolded proteins. Explore our pre-seeded PFFs to use in your research.
Neural factors are a class of protein molecules with neurotrophic activity that can promote the survival and regeneration of nerve cells. Explore our series of recombinant neural factors to support the culture and differentiation of nerve cells.
Neural antibodies can specifically label and recognize molecules on nerve cells, enabling a more comprehensive understanding and study of the biological properties, functions, and mechanisms of nerve cells in neurodegenerative diseases.
Covering iPSC neural cells, brain organoids, and microelectrode array services, our tools support neural development, disease modeling, and drug screening with high quality and reliable performance to meet diverse research needs.
Los marcadores de proteínas son un componente esencial en la investigación biológica y el desarrollo de fármacos. Ya sea para electroforesis de proteínas o western blot (Mancha Occidental), nuestros marcadores de proteínas teñidos previamente le ayudan a determinar rápidamente el peso molecular de la proteína objetivo o a evaluar la eficacia de la transferencia.
La estreptavidina es una proteína tetramérica que proporciona 4 sitios de unión de biotina de alta afinidad. Ofrecemos una amplia gama de productos preconjugados con estreptavidina para apoyar su investigación, así como proteínas biotiniladas.
El ajuste del anticuerpo de control de isotipo correspondiente para detectar la unión no específica puede reducir la generación de resultados falsos positivos y evaluar los posibles factores de influencia con precisión en el proceso de desarrollo de fármacos. Explore nuestros controles de isotipo para su investigación.
La eficacia de un anticuerpo terapéutico depende del fragmento Fab y de su actividad de unión al antígeno objetivo, pero también depende del fragmento Fc y de su interacción con receptores Fc clave, por lo que los candidatos deben probarse frente a un panel de receptores durante la ingeniería de anticuerpos. ¡Explore nuestra amplia colección de proteínas recombinantes del receptor Fc!
Nos comprometimos a acelerar la investigación, el desarrollo, la aprobación y la comercialización de vacunas contra enfermedades infecciosas. Con esta idea, ViruStop está especialmente diseñado para la investigación de virus
¡Disponemos de anticuerpos antígeno-específicos o neutralizantes para su investigación! ¡Si desea realizar ensayos de neutralización o evaluar títulos de anticuerpos, explore nuestro catálogo de anticuerpos!
¡En lugar de desarrollar sus propios ensayos, explore nuestros kits y ensayos diseñados para cuantificar rápidamente la presencia de antígenos o el título de anticuerpos!
Colony-stimulating factors (CSFs) are of low molecular cytokines that stimulate the proliferation, differentiation, and colony formation of bone marrow hematopoietic stem cells. CSFs bind to receptor proteins on the surface of hematopoietic stem cells to activate downstream signals that promote the production of specific types of hematopoietic cells (usually leukocytes) in response to infection. Studies have shown that CSFs are also up-regulated in a variety of malignancies through both immune-dependent and non-immune-dependent pathways to promote tumor cell growth, invasion, and migration.
Schematic diagram of CSFs and their receptor families
Different Types of CSF Targets
Macrophage colony-stimulating factor 1 (M-CSF) binds with its receptor (M-CSF R) to promote monocyte survival, promotes monocyte survival, monocyte-to-macrophage conversion, and macrophage proliferation. It also initiates and enhances macrophage killing of tumor cells and microorganisms, modulates macrophage release of cytokines and other inflammatory modulators.
Granulocyte-macrophage colony stimulating factor 2 (GM-CSF), through binding to its receptor GM-CSF R, promotes cell proliferation, survival, differentiation and other biological effects. Aberrant expression of GM-CSF leads to excessive inflammation, pain, chemotaxis and tissue damage, which promotes the production of other pathogenic and inflammatory cytokines.
Granulocyte colony-stimulating factor (G-CSF) mainly acts on the proliferation, differentiation and activation of hematopoietic cells of the neutrophil lineage. In vitro, it stimulates neutrophil precursors of bone marrow hematopoietic cells to differentiate and proliferate to form mature granulocyte colonies. This improves phagocytosis of neutrophils and promotes superoxide production.
To support drug discovery targeting CSFs/CSF Rs, ACROBiosystems has developed a series of high-quality cytokines for immunization, antibody drug screening and characterization; helping you accelerate your antibody drug development process.
Product Features
HEK293 expressed, close to natural conformation
High biological activity verified by SPR/ BLI/ Cell Assays
Strict quality control to guarantee high batch-to-batch consistency
ELISA as QC test to guarantee high quality, free protocol shared
Supporting your Cell Culture
To support ongoing cell therapy manufacture and development, ACROBiosystems has developed a wide array of high-quality cytokines to culture immune cells, stem cells, organoids, and various other types of cells.
Our premium-grade growth factors, including CSFs, have:
Low Endotoxin (≤ 0.1 EU/µg) Sterile, Animal-origin Free Validated Bioactivity and Lot-to-Lot Consistency Seamlessly transition to GMP-grade
Immobilized Human M-CSF R, Fc Tag (Cat. No. CSR-H5258) at 2 μg/mL (100 μL/well) can bind Biotinylated Human M-CSF, His,Avitag (Cat. No. MCF-H82E6) with a linear range of 0.1-2 ng/mL (QC tested).
Immobilized Human GM-CSF, premium grade (Cat. No. GMF-H4214) at 1 μg/mL (100 μL/well) can bind Human GM-CSF R alpha, Fc Tag (Cat. No. GRA-H5255) with a linear range of 0.5-16 ng/mL (QC tested).
Immobilized Human G-CSF, premium grade (Cat. No. GCF-H5214) at 2 μg/mL (100 μL/well) can bind Biotinylated Human G-CSF R, Avitag,His Tag (Cat. No. GCR-H82E4) with a linear range of 0.156-1.25 μg/mL (QC tested).
Affinity (SPR)
Biotinylated Human M-CSF, His,Avitag (Cat. No. MCF-H82E6) immobilized on SA Chip can bind Human M-CSF R, His Tag (Cat. No. CSR-H5228) with an affinity constant of 0.309 μM as determined in a SPR assay (Biacore T200) (Routinely tested).
Human GM-CSF R alpha, His Tag (Cat. No. GRA-H52H7) captured on CM5 Chip via anti-His antibody, can bind Human GM-CSF, premium grade (Cat. No. GMF-H4214) with an affinity constant of 16.1 nM as determined in SPR assay (Biacore T200) (QC tested).
Affinity (BLI)
Loaded Human M-CSF, His Tag (Cat. No. MCF-H5247) on HIS1K Biosensor, can bind Human M-CSF R, Fc Tag, low endotoxin (Cat. No. CSR-H5258) with an affinity constant of 3.29 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).
Loaded Biotinylated Human GM-CSF, epitope tag free, primary amine labeling (Cat. No. GMF-H8214) on SA Biosensor, can bind Human GM-CSF R alpha, His Tag (Cat. No. GRA-H52H7) with an affinity constant of 23.1 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).
High biological activity (Cell Base)
Human M-CSF, His Tag (Cat. No. MCF-H5247) stimulates proliferation of RAW264.7 cells. The EC50 for this effect is 4.40-5.27 ng/mL (Routinely tested).
Human GM-CSF, premium grade(Cat. No. GMF-H4214) stimulates proliferation of GM-CSF-activated TF-1 cell. The specific activity of Human GM-CSF, premium grade is > 1.0ⅹ10^7 IU/mg , which is calibrated against human GM-CSF WHO International Standard (NIBSC code: 88/646) (QC tested).