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> Colony-Stimulating Factors and Receptors
Schematic diagram of CSFs and their receptor families
Macrophage colony-stimulating factor 1 (M-CSF) binds with its receptor (M-CSF R) to promote monocyte survival, promotes monocyte survival, monocyte-to-macrophage conversion, and macrophage proliferation. It also initiates and enhances macrophage killing of tumor cells and microorganisms, modulates macrophage release of cytokines and other inflammatory modulators.
Granulocyte-macrophage colony stimulating factor 2 (GM-CSF), through binding to its receptor GM-CSF R, promotes cell proliferation, survival, differentiation and other biological effects. Aberrant expression of GM-CSF leads to excessive inflammation, pain, chemotaxis and tissue damage, which promotes the production of other pathogenic and inflammatory cytokines.
Granulocyte colony-stimulating factor (G-CSF) mainly acts on the proliferation, differentiation and activation of hematopoietic cells of the neutrophil lineage. In vitro, it stimulates neutrophil precursors of bone marrow hematopoietic cells to differentiate and proliferate to form mature granulocyte colonies. This improves phagocytosis of neutrophils and promotes superoxide production.
HEK293 expressed, close to natural conformation
High biological activity verified by SPR/ BLI/ Cell Assays
Strict quality control to guarantee high batch-to-batch consistency
ELISA as QC test to guarantee high quality, free protocol shared
Our premium-grade growth factors, including CSFs, have:
| Molecule | Cat. No. | Species | Product Description | Preorder/Order |
|---|
Immobilized Human M-CSF R, Fc Tag (Cat. No. CSR-H5258) at 2 μg/mL (100 μL/well) can bind Biotinylated Human M-CSF, His,Avitag (Cat. No. MCF-H82E6) with a linear range of 0.1-2 ng/mL (QC tested).
Human M-CSF, His Tag (Cat. No. MCF-H5247) stimulates proliferation of RAW264.7 cells. The EC50 for this effect is 4.40-5.27 ng/mL (Routinely tested).
Human GM-CSF, premium grade(Cat. No. GMF-H4214) stimulates proliferation of GM-CSF-activated TF-1 cell. The specific activity of Human GM-CSF, premium grade is > 1.0ⅹ10^7 IU/mg , which is calibrated against human GM-CSF WHO International Standard (NIBSC code: 88/646) (QC tested).
Hamilton J A. Colony-stimulating factors in inflammation and autoimmunity[J]. Nature Reviews Immunology, 2008, 8(7): 533-544.
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