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CD3

Brief Information

Name:T cell surface glycoprotein CD3
Target Synonym:CD3 Complex
Number of Launched Drugs:7
Number of Drugs in Clinical Trials:157
Lastest Research Phase:Approved

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Part of Bioactivity data

CDE-AHFP1-Cell-based assay
 CD3 FACS

Flow cytometric analysis of Jurkat cells staining with APC-Labeled Monoclonal Anti-Human CD3 Antibody, Mouse IgG2a (Clone: OKT3) (Cat. No. CDE-AHFP1) at 1:50 dilution (2μL of the antibody stock solution corresponds to labeling of 1e6 cells in a final volume of 100 µL) , compared with isotype control antibody. APC signal was used to evaluate the binding activity (QC tested).

CDE-PCFP1-Cell-based assay
 CD3 FACS

Flow cytometric analysis of Jurkat cells staining with PE-Labeled Monoclonal Anti-Human CD3 Antibody, Mouse IgG2a (Clone: OKT3) (Cat. No. CDE-PCFP1) at 1:50 dilution (2μL of the antibody stock solution corresponds to labeling of 1e6 cells in a final volume of 100 µL) , compared with isotype control antibody. PE signal was used to evaluate the binding activity (QC tested).

CDE-M532-ELISA
 CD3 ELISA

Immobilized Human CD3E&CD3D Heterodimer Protein (Cat. No. CDD-H52Wa) at 1 μg/mL (100 μL/well) can bind Monoclonal Anti-Human CD3 Antibody, Mouse IgG1 (UCHT1) (Cat. No. CDE-M532) with a linear range of 0.1-3 ng/mL (QC tested).

CDE-BV84G0-MALS-HPLC
CD3 MALS images

The purity of Biotinylated Anti-Human CD3 Antibody, Mouse IgG2a,Avitag (Clone: OKT3), premium grade (Cat. No. CDE-BV84G0) is more than 95% and the molecular weight of this protein is around 130-160 kDa verified by SEC-MALS.

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Mouse monoclonal antibody against human CD3 antigen of T lymphocyte (Wuhan Institute of Biological Products) Approved Wuhan Institute Of Biological Products Co Ltd Mainland China Rejection of organ transplantation Wuhan Institute Of Biological Products Co Ltd 1999-01-01 Rejection of organ transplantation Details
Tebentafusp ImmTAC-gp-100; IMC-gp-100; IMC-gp100 Approved Immunocore Ltd KIMMTRAK United States Uveal melanoma Immunocore Ltd 2022-01-25 Uveal melanoma; Melanoma Details
Teclistamab JNJ-64007957; JNJ-64007959; JNJ-7957 Approved Johnson & Johnson Innovative Medicine, Genmab A/S TECVAYLI, TECAYLI EU Multiple Myeloma Janssen-Cilag International Nv 2022-08-23 Hematologic Diseases; Hematologic Neoplasms; Multiple Myeloma Details
Teplizumab MGA-031; PRV-031; hOKT3-γ1-ala-ala; hOKT3-gamma-1-ala-ala Approved Tolerance Therapeutics Inc TZIELD United States Diabetes Mellitus, Type 1 Provention Bio Inc 2022-11-17 Diabetes Mellitus, Type 1; Rejection of renal transplantation; Glucose Intolerance; Hypoglycemia; Psoriasis; Diabetes Mellitus, Experimental Details
Mosunetuzumab BTCT-4465A; RO-7030816; CD20-TBD; RG-7828 Approved Genentech Inc Lunsumio EU Lymphoma, Follicular Roche Registration Gmbh 2022-06-03 Lymphoma, B-Cell; Lymphoma, B-Cell, Marginal Zone; Lymphoma, Large B-Cell, Diffuse; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Lymphoma, Follicular; Lupus Erythematosus, Systemic; Lymphoma; Lymphoma, Non-Hodgkin; Leukemia, Lymphocytic, Chronic, B-Cell Details
Epcoritamab GEN-3013; ABBV-GMAB-3013 Approved Genmab A/S, Abbvie Inc Tepkinly, TEPKINLY, EPKINLY United States Lymphoma, Large B-Cell, Diffuse Genmab Us Inc 2023-05-19 Lymphoma, B-Cell; Lymphoma, B-Cell, Marginal Zone; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Follicular; Lymphoma, Mantle-Cell; Primary mediastinal B cell lymphoma; Richter's Syndrome; Lymphoma; Lymphoma, Non-Hodgkin; Leukemia, Lymphocytic, Chronic, B-Cell Details
Blinatumomab BiTE-MT-103; bscCD19xCD3; AMG-103; MT-103; MEDI-538 Approved Micromet Inc Blincyto, 倍利妥 United States Precursor B-Cell Lymphoblastic Leukemia-Lymphoma Amgen Inc 2014-12-03 Leukemia; Leukemia, Myelogenous, Chronic; Neoplasm, Residual; Lymphoma, B-Cell; Lymphoma, Large B-Cell, Diffuse; Multiple Myeloma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Leukemia, B-Cell; Philadelphia Chromosome; Lymphoma, Non-Hodgkin; Burkitt Lymphoma; Lymphoma; Leukemia, Lymphocytic, Chronic, B-Cell Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
M-701 M-701 Phase 3 Clinical Wuhan Yzy Biopharma Co Ltd Ovarian Neoplasms; Solid tumours; Hydrothorax; Stomach Neoplasms; Neoplasms; Ascites; Colorectal Neoplasms; Pleural Effusion, Malignant; Carcinoma, Non-Small-Cell Lung Details
ABBV-383 TNB-383B; ABBV-383 Phase 3 Clinical Teneobio Inc, Abbvie Inc Multiple Myeloma Details
IMC-F106C IMC-F106C; PRAME HLA-A02 Phase 3 Clinical Immunocore Ltd Solid tumours; Melanoma Details
Alnuctamab CC-93269; EM-901; BMS-986349 Phase 3 Clinical Engmab Ag Multiple Myeloma Details
Catumaxomab LP000 Phase 3 Clinical Trion Research, Neovii Biotech Gmbh Ovarian Neoplasms; Stomach Neoplasms; Carcinoma; Neoplasms; Carcinoma, Ovarian Epithelial; Colonic Neoplasms; Urinary Bladder Neoplasms; Ascites; Breast Neoplasms Details
Flotetuzumab S-80880; MGD-006; RES-234 Phase 2 Clinical Macrogenics Inc Leukemia, Myelogenous, Chronic; Hematologic Neoplasms; Leukemia; Leukemia, Hairy Cell; Mastocytosis, Systemic; Hodgkin Disease; Blastic Plasmacytoid Dendritic Cell Neoplasm; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Neoplasms, Plasma Cell; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Leukemia, B-Cell; Leukemia, Myeloid, Acute; Leukemia, Biphenotypic, Acute Details
Anti-CD3/humanized 3F8 bispecific antibody-activated T lymphocytes (University of Virginia) Phase 2 Clinical University Of Virginia Neuroblastoma Details
Imvotamab IGM-2323 Phase 2 Clinical Igm Biosciences Inc Lymphoma, B-Cell, Marginal Zone; Myositis; Lupus Erythematosus, Cutaneous; Arthritis, Rheumatoid; Lymphoma, Large B-Cell, Diffuse; Lupus Erythematosus, Systemic; Lymphoma, Mantle-Cell; Lymphoma, Follicular; Arthritis; Lymphoma, Non-Hodgkin Details
Foralumab TZLS-401; NI-0401/α-CD3; NI-0401 Phase 2 Clinical Novimmune Sa, Bristol-Myers Squibb Company Respiratory Tract Infections; Diabetes Mellitus, Type 2; Metabolic Dysfunction-Associated Steatotic Liver Disease; Coronavirus Disease 2019 (COVID-19); Multiple Sclerosis, Chronic Progressive; Multiple Sclerosis; Alzheimer Disease; Crohn Disease Details
GNR-084 GNR-084 Phase 2 Clinical Generium Pharmaceuticals, Iontas Precursor Cell Lymphoblastic Leukemia-Lymphoma; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma Details
Anti-CD3 and anti-HER2 BiTE-expressing T cell (MedImmune) Phase 2 Clinical University Of Michigan, Huazhong University Of Science And Technology, University Of Virginia Cancer Center, Medimmune Breast Neoplasms Details
Vibecotamab XmAb-14045 Phase 2 Clinical Xencor Inc Leukemia, Myeloid; Myelodysplastic Syndromes; Blastic Plasmacytoid Dendritic Cell Neoplasm; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Leukemia, Myeloid, Acute Details
α/β CD3+/CD19+ cell depleted stem cell therapy (Mitchell Cairo) Phase 2 Clinical New York Medical College Leukemia; Anemia; Thalassemia; Hodgkin Disease; Anemia, Aplastic; Thrombocytopenia; Lymphoma, Non-Hodgkin; Kostmann Syndrome; Anemia, Sickle Cell Details
MK-6070 HPN-328; MK-6070 Phase 2 Clinical Harpoon Therapeutics Small Cell Lung Carcinoma Details
Cibisatamab CEA-TCB; RG-7802; RO-6958688; CEA-CD3 TCB Phase 2 Clinical F. Hoffmann-La Roche Ltd Solid tumours; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung Details
CD3/CD19 neg allogeneic BMT (National Institute of Allergy and Infectious Diseases/University of Pittsburgh) Phase 2 Clinical National Institute Of Allergy And Infectious Diseases (Niaid), University Of Pittsburgh Primary Immunodeficiency Diseases; Female Urogenital Diseases; Inflammation Details
HPN-536 HPN-536 Phase 2 Clinical Harpoon Therapeutics Neoplasms Details
MBS-303 MBS-303 Phase 2 Clinical Beijing Mabworks Biotech Co Ltd Lymphoma, B-Cell; Lymphoma, Non-Hodgkin Details
HBM-7022 HBM-7022; AZD-5863 Phase 2 Clinical Harbour Biomed Esophageal Neoplasms; Stomach Neoplasms; Pancreatic Neoplasms; Neoplasms; Digestive System Neoplasms; Esophageal adenocarcinoma; Carcinoma, Pancreatic Ductal; Gastrointestinal Neoplasms Details
TAK-280 MVC-280; TAK-280 Phase 2 Clinical Maverick Therapeutics Inc Solid tumours; Neoplasms; Neoplasm Metastasis Details
GB-261 GB-261 Phase 2 Clinical Genor Biopharma Co Ltd Lymphoma, B-Cell; Leukemia, Lymphoid; Lymphoma, Non-Hodgkin; Leukemia, Lymphocytic, Chronic, B-Cell Details
REGN-5459 REGN-5459 Phase 2 Clinical Regeneron Pharmaceuticals Inc Multiple Myeloma; Renal Insufficiency, Chronic Details
IBI-3003 IBI3003; IBI-3003 Phase 2 Clinical Innovent Biologics(Suzhou) Co Ltd Multiple Myeloma Details
MBS-314 MBS-314 Phase 2 Clinical Beijing Mabworks Biotech Co Ltd Multiple Myeloma Details
RO7515629 RO7515629; RO-7515629; RG-6353 Phase 2 Clinical F. Hoffmann-La Roche Ag Ovarian Neoplasms; Carcinoma, Renal Cell; Pancreatic Neoplasms; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung Details
BI-764532 BI-764532; OBT620 Phase 2 Clinical C.H. Boehringer Sohn Ag & Co. Kg Small Cell Lung Carcinoma; Neoplasms; Neuroendocrine Tumors; Carcinoma, Neuroendocrine; Glioma Details
GEN3017 GEN-3017 Phase 2 Clinical Genmab A/S Hematologic Neoplasms; Hodgkin Disease; Lymphoma, Non-Hodgkin Details
MP0533 MP0533 Phase 2 Clinical Molecular Partners Ag Leukemia, Myeloid, Acute Details
CD30 biAb-AATC(The Medical College Of Wisconsin Nonprofit) Phase 2 Clinical The Medical College Of Wisconsin Nonprofit Lymphoma, B-Cell; Leukemia; Hodgkin Disease; Lymphoma; Lymphoma, Large-Cell, Anaplastic; Lymphoma, T-Cell, Cutaneous Details
APVO-436 APVO-436; APVO436 Phase 2 Clinical Aptevo Myelodysplastic Syndromes; Leukemia, Myeloid, Acute Details
Emfizatamab GNC-038 Phase 2 Clinical Sichuan Baili Pharmaceutical Co Ltd, SystImmune Solid tumours; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Extranodal NK-T-Cell; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Lymphoma, Non-Hodgkin; Lymphoma, T-Cell; Central Nervous System Lymphoma Details
GEN-1047 GEN-1047 Phase 2 Clinical Genmab A/S Carcinoma, Non-Small-Cell Lung Details
REGN-4336 REGN-4336 Phase 2 Clinical Regeneron Pharmaceuticals Inc Prostatic Neoplasms, Castration-Resistant Details
CM-350 CM-350 Phase 2 Clinical Keymed Biosciences Co Ltd Solid tumours Details
1-A-46 BR-110; 1A46; 1-A-46; CMG1A46; CMG1A-46; BR110 Phase 2 Clinical Chengdu Chimagen Biosciences Co Ltd, Hisun Biopharmaceutical Co Ltd, BioRay Pharmaceutical Co Ltd Lymphoma, B-Cell; Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Lymphoma, Non-Hodgkin Details
LBL-034 LBL-034 Phase 2 Clinical Nanjing Leads Biolabs Co Ltd Neoplasms; Multiple Myeloma Details
LBL-033 LBL-033 Phase 2 Clinical Nanjing Leads Biolabs Co Ltd Neoplasms Details
CM-336(Connaught Biomedical Technology) CM-336 Phase 2 Clinical Keymed Biosciences Co Ltd Multiple Myeloma Details
ICP-B02 CM-355; ICP-B02 Phase 2 Clinical Beijing Tiannuo Jiancheng Pharmaceutical Technology Co Ltd, Keymed Biosciences Co Ltd Hematologic Neoplasms; Hematoma; Lymphoma; Lymphoma, Non-Hodgkin Details
SMET-12 SMET-12 Phase 2 Clinical Zhejiang Shimai Pharmaceutical Co Ltd Solid tumours; Carcinoma, Non-Small-Cell Lung Details
QLS-31905 QLS-31905 Phase 2 Clinical Qilu Pharmaceutical Co Ltd Solid tumours; Neoplasms Details
Nebratamig GNC-035 Phase 2 Clinical Sichuan Baili Pharmaceutical Co Ltd Solid tumours; Hematologic Neoplasms; Breast Neoplasms; Metastatic breast cancer; Lymphoma, Non-Hodgkin; Leukemia, Lymphocytic, Chronic, B-Cell Details
TAK-186 EGFR x CD3 COBRA; MVC-101; TAK-186 Phase 2 Clinical Takeda Pharmaceutical Co Ltd Solid tumours; Squamous Cell Carcinoma of Head and Neck; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung Details
EMB-06 EMB-06; EMB06 Phase 2 Clinical Shanghai Epimab Biotherapeutics, Inc Multiple Myeloma Details
AZD-0486 TNB-486; AZD-0486; AZD0486 Phase 2 Clinical Teneobio Inc Lymphoma, B-Cell; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Follicular; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin Details
BNT-142 BNT-142 Phase 2 Clinical Biontech Se Solid tumours Details
CN-201 CN-201 Phase 2 Clinical Curon Biopharmaceutical Ltd Lymphoma, B-Cell; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Leukemia, B-Cell; Lymphoma, Non-Hodgkin Details
ZG006 ZG006; ZG-006 Phase 2 Clinical Gensun Biopharma Inc, Suzhou Zelgen Biopharmaceuticals Co Ltd Solid tumours; Neoplasms; Small Cell Lung Carcinoma; Carcinoma, Neuroendocrine Details
EX-103 EX-103; EX103 Phase 2 Clinical Guangzhou Excelmab Inc Arthritis, Rheumatoid; Lymphoma, Non-Hodgkin; Leukemia, Lymphocytic, Chronic, B-Cell Details
Anti-CD3 monoclonal antibody (Jinan Tiankang Biological Products) Phase 2 Clinical Jinan Tiankang Biological Products Co Ltd Anemia, Aplastic Details
Cevostamab RG-6160; BFCR-4350A; RO-7187797 Phase 2 Clinical Genentech Inc Multiple Myeloma Details
Anti-CD3/anti-EGFR -activated T cells (Barbara Ann Karmanos Cancer Institute) Phase 2 Clinical Barbara Ann Karmanos Cancer Institute, University Of Virginia Glioblastoma; Pancreatic Neoplasms Details
Ubamatamab REGN-4018 Phase 2 Clinical Regeneron Pharmaceuticals Inc Ovarian Neoplasms; Peritoneal Neoplasms; Endometrial Neoplasms; Fallopian Tube Neoplasms Details
Anti-CD3-anti-HER2-activated T cells Phase 2 Clinical Transtarget Prostatic Neoplasms, Castration-Resistant; Breast Neoplasms; Prostatic Neoplasms Details
JCAR-014 JCAR-014; JCAR021 Phase 2 Clinical Fred Hutchinson Cancer Research Center, Memorial Sloan Kettering Cancer Center, Seattle Children'S Research Institute, Juno Therapeutics Inc Lymphoma, B-Cell; Leukemia; Leukemia, Lymphoid; Hodgkin Disease; Lymphoma, Large B-Cell, Diffuse; Candidiasis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Lymphoma, Mantle-Cell; Primary mediastinal B cell lymphoma; Leukemia, B-Cell; Lymphoma, Non-Hodgkin; Leukemia, Lymphocytic, Chronic, B-Cell Details
A-319 A-319 Phase 1 Clinical Evive Biotech Ltd Lymphoma, B-Cell; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Leukemia, B-Cell Details
BCMA TriTAC HPN-217 Phase 1 Clinical Harpoon Therapeutics, Abbvie Inc Multiple Myeloma Details
Membrane bound ligand T-SIGn virus NG-348 Phase 1 Clinical Akamis Bio Ltd Neoplasms Details
NG-641 EnAd-FAP-BiTE; EnAd-FAP-Tac; NG-641; NG-aFAP Phase 1 Clinical Akamis Bio Ltd, University Of Oxford Squamous Cell Carcinoma of Head and Neck; Neoplasms, Glandular and Epithelial; Neoplasm Metastasis Details
Vixtimotamab T-564; AMV-564 Phase 1 Clinical Amphivena Therapeutics Inc Solid tumours; Myelodysplastic Syndromes Details
MGD-014 MGD-014 Phase 1 Clinical Macrogenics Inc HIV Infections Details
JNJ-63898081 JNJ-8081; JNJ-63898081 Phase 1 Clinical Johnson & Johnson Innovative Medicine Neoplasms Details
K-193 K-193 Phase 1 Clinical Beijing Lvzhu Biological Technology Co Ltd Lymphoma, B-Cell Details
Anti-EGFR-bispecific antibody armed activated T-cell therapy (Memorial Sloan Kettering Cancer Center) Phase 1 Clinical Memorial Sloan Kettering Cancer Center Pancreatic Neoplasms Details
Runimotamab BTRC-4017A; RG-6194; RO-7227780 Phase 1 Clinical F. Hoffmann-La Roche Ltd Solid tumours; Neoplasms Details
Autologous T-cell therapy (anti-PSMA-CD3), Roger Williams Medical Center Phase 1 Clinical Roger Williams Medical Center Prostatic Neoplasms Details
ONO-4685 ONO-4685 Phase 1 Clinical Merus Nv Psoriasis; Lymphoma, T-Cell; Plaque psoriasis Details
WVT-078(Novartis Pharma) WVT-078 Phase 1 Clinical Novartis Pharma Ag Multiple Myeloma Details
M-802(Wuhan Yzy Biopharma/CSPC Pharmaceutical) M-802 Phase 1 Clinical Wuhan Yzy Biopharma Co Ltd, CSPC Pharmaceutical Group Ltd Ovarian Neoplasms; Solid tumours; Stomach Neoplasms; Breast Neoplasms Details
Emirodatamab AMG-427 Phase 1 Clinical Amgen Inc Leukemia, Myeloid, Acute Details
JNJ-63709178 JNJ-9178; CNTO-9958; JNJ-63709178 Phase 1 Clinical Johnson & Johnson Innovative Medicine, Genmab A/S Leukemia, Myeloid, Acute Details
SAR-442257 SAR-442257 Phase 1 Clinical Sanofi Neoplasms Details
CC-1 CC-1 Phase 1 Clinical University Of Tubingen, German Cancer Research Center (Dkfz) Prostatic Neoplasms, Castration-Resistant; Prostatic Neoplasms; Carcinoma, Squamous Cell Details
Acapatamab AMG-160 Phase 1 Clinical Amgen Inc Prostatic Neoplasms, Castration-Resistant; Carcinoma, Non-Small-Cell Lung Details
Pavurutamab AMG-701 Phase 1 Clinical Amgen Inc Multiple Myeloma Details
Xaluritamig AMG-509 Phase 1 Clinical Xencor Inc, Amgen Inc Prostatic Neoplasms, Castration-Resistant Details
CC-3 CC-3 Phase 1 Clinical Eberhard Karls University Of Tubingen, Germany Colorectal Neoplasms; Gastrointestinal Neoplasms Details
JS-203 JS-203 Phase 1 Clinical Shanghai Junshi Biological Engineering Co Ltd Lymphoma, B-Cell; Lymphoma, Non-Hodgkin Details
BC-004 BC-004 Phase 1 Clinical Shandong Buchang Pharmaceuticals Co Ltd Solid tumours; Breast Neoplasms Details
JY-016 JY-016 Phase 1 Clinical Beijing Jingyitaixiang Technology Development Co Ltd, Beijing Eastern Biotech Co Ltd Solid tumours; Colorectal Neoplasms; Lung Neoplasms Details
EX-105 EX-105; EX105 Phase 1 Clinical Guangzhou Excelmab Inc Solid tumours Details
EMB-07 EMB-07 Phase 1 Clinical Shanghai Epimab Biotherapeutics, Inc Solid tumours; Ovarian Neoplasms; Stomach Neoplasms; Neoplasms; Triple Negative Breast Neoplasms; Adenocarcinoma of Lung; Pancreatic Neoplasms; Urinary Bladder Neoplasms; Prostatic Neoplasms; Colorectal Neoplasms; Lymphoma; Uterine Neoplasms; Neoplasm Metastasis Details
BA-3182 BA-3182 Phase 1 Clinical Bioatla Solid tumours; Adenocarcinoma Details
BA-1202 BA-1202 Phase 1 Clinical Shandong Boan Biotechnology Co Ltd Solid tumours Details
CLN-978 CLN-978 Phase 1 Clinical Adimab LLC Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Lymphoma, Non-Hodgkin Details
MGD-024 MGD-024 Phase 1 Clinical Macrogenics Inc Leukemia, Myelogenous, Chronic; Leukemia, Hairy Cell; Hodgkin Disease; Myelodysplastic Syndromes; Neoplasms; Blastic Plasmacytoid Dendritic Cell Neoplasm; Leukemia, B-Cell; Leukemia, Myeloid, Acute Details
ARB-202 ARB-202 Phase 1 Clinical Arbele Corp Liver Neoplasms; Biliary Tract Neoplasms; Stomach Neoplasms; Pancreatic Neoplasms; Cholangiocarcinoma; Colorectal Neoplasms; Esophageal adenocarcinoma; Gastrointestinal Neoplasms Details
CX-904 CX-904 Phase 1 Clinical Amgen Inc, Cytomx Therapeutics Inc Solid tumours; Neoplasms Details
CLN-049 CLN-049 Phase 1 Clinical University Of Tubingen, German Cancer Research Center (Dkfz) Myelodysplastic Syndromes; Leukemia, Myeloid, Acute Details
XmAb-819 XmAb-819 Phase 1 Clinical Xencor Inc Kidney Neoplasms; Carcinoma, Renal Cell Details
JNJ-70218902 JNJ-70218902 Phase 1 Clinical Johnson & Johnson Innovative Medicine Neoplasms Details
JNJ-67571244 JNJ-67571244; JNJ-67371244; JNJ-1244 Phase 1 Clinical Johnson & Johnson Myelodysplastic Syndromes; Leukemia, Myeloid, Acute Details
SCTB-35 SCTB35; SCTB-35 Phase 1 Clinical SinoCelltech Ltd Lymphoma, B-Cell Details
JNJ-87890387 JNJ-87890387 Phase 1 Clinical Janssen Research & Development Llc Solid tumours Details
XmAb-541 XmAb541; XmAb-541 Phase 1 Clinical Xencor Inc Ovarian Neoplasms; Ovarian germ cell tumor; Germinoma; Endometrial Neoplasms; Neoplasms, Germ Cell and Embryonal Details
[89Zr]Zr-BI-764532 Phase 1 Clinical C.H. Boehringer Sohn Ag & Co. Kg, Boehringer Ingelheim Gmbh Small Cell Lung Carcinoma; Carcinoma, Neuroendocrine Details
TGI-6 TGI-6 Phase 1 Clinical Hefei TG ImmunoPharma Co Ltd Solid tumours; Colorectal Neoplasms Details
SIM-0500 SIM-0500; SIM0500 Phase 1 Clinical Hainan Xiansheng Re Ming Pharmaceutical Co Ltd Bone Marrow Neoplasms; Multiple Myeloma Details
Recombinant anti BCMA/CD3 bispecific antibody(Hualan Genetic Engineering) Phase 1 Clinical Hualan Genetic Engineering (Henan) Co Ltd Multiple Myeloma Details
Oncolytic Virus R130(Yunying Medical) R-130-OV; R130; R-130 Phase 1 Clinical Shanghai Yunying Medical Technology Co Ltd Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Gastrointestinal Neoplasms; Melanoma; Laryngeal Neoplasms; Pharyngeal Neoplasms; Lung Neoplasms; Fallopian Tube Neoplasms; Colorectal Neoplasms; Genital Neoplasms, Female; Bone Neoplasms; Peritoneal Neoplasms; Sarcoma; Osteosarcoma; Head and Neck Neoplasms; Brain Neoplasms; Otorhinolaryngologic Neoplasms; Small Cell Lung Carcinoma; Pancreatic Neoplasms; Nose Neoplasms; Stomach Neoplasms; Esophageal Neoplasms; Carcinoma; Carcinoma, Bronchogenic; Liver Neoplasms; Ovarian Neoplasms; Kidney Neoplasms Details
ASP2074 ASP-2074; ASP2074 Phase 1 Clinical Astellas Pharma Global Development Inc Solid tumours Details
OBT620 OBT620 Phase 1 Clinical Boehringer Ingelheim Gmbh, Oxford Biotherapeutics Ltd Small Cell Lung Carcinoma Details
CBA-1535 CBA-1535 Phase 1 Clinical Chiome Bioscience Inc Small Cell Lung Carcinoma; Triple Negative Breast Neoplasms; Mesothelioma; Carcinoma, Non-Small-Cell Lung Details
JANX-008 EGFR-TRACTr; JANX008; JANX-008 Phase 1 Clinical Janux Therapeutics Inc Solid tumours; Squamous Cell Carcinoma of Head and Neck; Carcinoma, Renal Cell; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung Details
JANX-007 JANX-007; PSMA-TRACTr Phase 1 Clinical Janux Therapeutics Inc Prostatic Neoplasms, Castration-Resistant; Prostatic Neoplasms Details
TQB-2934 TQB2934; TQB-2934 Phase 1 Clinical Nanjing Shunxin Pharmaceuticals Co Ltd Of Chiatai Tianqing Pharmaceutical Group Multiple Myeloma Details
JNJ-80948543 JNJ-80948543 Phase 1 Clinical Janssen Research & Development Llc Lymphoma, B-Cell; Neoplasms; Lymphoma, Non-Hodgkin; Leukemia, Lymphocytic, Chronic, B-Cell Details
PIT-565 PIT-565 Phase 1 Clinical Novartis Pharma Ag Lymphoma, B-Cell; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Lupus Erythematosus, Systemic; Leukemia, Myeloid, Acute Details
CC-312 CC-312 Phase 1 Clinical CytoCares (Shanghai) Inc Hematologic Neoplasms; Lymphoma, B-Cell; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Lymphoma, Non-Hodgkin; Leukemia, Lymphocytic, Chronic, B-Cell Details
ASP-2138 ASP-2138 Phase 1 Clinical Astellas Pharma Global Development Inc, Xencor Inc Stomach Neoplasms; Esophageal Neoplasms; Pancreatic Neoplasms Details
ISB-2001 ISB-2001 Phase 1 Clinical Ichnos Sciences Sa Multiple Myeloma Details
GR-1901 GR1901; GR-1901 Phase 1 Clinical Chongqing Zhixiang Jintai Biopharmaceutical Co Ltd, Genrix (Shanghai) Biopharmaceutical Co Ltd Leukemia, Myeloid, Acute Details
AMG-794 AMG-794 Phase 1 Clinical Amgen Inc Carcinoma, Ovarian Epithelial; Carcinoma, Non-Small-Cell Lung Details
QLS-31904 QLS31904; QLS-31904 Phase 1 Clinical Qilu Pharmaceutical Co Ltd Solid tumours Details
YK-012 YK012 Phase 1 Clinical Yikesite (Beijing) Pharmaceutical Technology Development Co Ltd Lymphoma, B-Cell Details
RO-7428731 RO-7428731; RG-6156 Phase 1 Clinical F. Hoffmann-La Roche Ltd Glioblastoma Details
GBR-1342 GBR-1342; ISB-1342 Phase 1 Clinical Glenmark Pharmaceuticals Ltd Multiple Myeloma Details
Recombinant humanized anti-CD19/CD3 bispecific antibody(New Time Pharmaceutical) LNF-1904 Phase 1 Clinical Shandong New Time Pharmaceutical Co Ltd Lymphoma, B-Cell; Leukemia, B-Cell Details
XmAb-968 XmAb968 Phase 1 Clinical Xencor Inc Hematologic Neoplasms; Leukemia, Promyelocytic, Acute Details
GR-1803 GR-1803 Phase 1 Clinical Chongqing Zhixiang Jintai Biopharmaceutical Co Ltd, Genrix (Shanghai) Biopharmaceutical Co Ltd Multiple Myeloma Details
XmAb-18968 XmAb-18968 Phase 1 Clinical The Medical College Of Wisconsin Nonprofit Leukemia, Myeloid, Acute Details
SQZ-622(Novartis Pharma) SQZ-622 Phase 1 Clinical Novartis Pharma Ag Leukemia, Myeloid, Acute Details
Forimtamig RG-6234 Phase 1 Clinical F. Hoffmann-La Roche Ltd Multiple Myeloma Details
RG-6232 RG-6232 Phase 1 Clinical F. Hoffmann-La Roche Ltd Melanoma Details
RG-6007 RO-7283420; RG-6007 Phase 1 Clinical F. Hoffmann-La Roche Ltd Leukemia, Myeloid, Acute Details
SAR-443216 SAR-443216 Phase 1 Clinical Sanofi Solid tumours; Stomach Neoplasms; Neoplasms; Breast Neoplasms; Lung Neoplasms Details
Recombinant oncolytic type II herpes simplex virus (Binhui Biopharmaceutical) BS-006; oHSV2-BiTEs Phase 1 Clinical Wuhan Binhui Biotechnology Co Ltd Solid tumours; Neoplasms; Melanoma; Uterine Cervical Neoplasms Details
JNJ-78306358 JNJ-78306358; JNJ-6358 Phase 1 Clinical Janssen Research & Development Llc Solid tumours Details
F-182112 F-182112; F182112 Phase 1 Clinical Shandong New Time Pharmaceutical Co Ltd Multiple Myeloma Details
TNB-585 TNB-585; AMG-340 Phase 1 Clinical Teneobio Inc Prostatic Neoplasms, Castration-Resistant Details
BC-3448 BC3448; BC-3448 Phase 1 Clinical Solid tumours Details
IBI-389 IBI-389 Phase 1 Clinical Innovent Biologics(Suzhou) Co Ltd Solid tumours; Neoplasms Details
hEGFRvIII-CD3 Bi-scFv Phase 1 Clinical Duke University Glioblastoma; Glioma Details
JNJ-78278343 Phase 1 Clinical Janssen Research & Development Llc Prostatic Neoplasms, Castration-Resistant; Prostatic Neoplasms Details
TQB-2825 TQB-2825 Phase 1 Clinical Wuxi Biologics Co Ltd Hematologic Neoplasms Details
RGV-004 RGV-004 Phase 1 Clinical Hangzhou Rongu Biotechnology Co Ltd Lymphoma, B-Cell Details
Recombinant humanized anti-BCMA/CD3 bispecific antibody(New Time Pharmaceutical) Phase 1 Clinical Shandong New Time Pharmaceutical Co Ltd Multiple Myeloma Details
NVG-111 NVG-111 Phase 1 Clinical NovalGen Ltd Lymphoma, Large B-Cell, Diffuse; Lymphoma, Mantle-Cell; Lymphoma, Follicular; Melanoma; Carcinoma, Non-Small-Cell Lung; Leukemia, Lymphocytic, Chronic, B-Cell Details
BI-765049 BI-765049; OBT-624 Phase 1 Clinical Oxford Biotherapeutics Ltd Solid tumours Details
GNC-039 GNC-039 Phase 1 Clinical Sichuan Baili Pharmaceutical Co Ltd Solid tumours; Hematologic Neoplasms; Glioma; Neoplasm Metastasis Details
RO-7425781 RO-7425781 Phase 1 Clinical F. Hoffmann-La Roche Ltd Multiple Myeloma Details
RO-7293583 RO-7293583 Phase 1 Clinical F. Hoffmann-La Roche Ltd Skin Melanoma; Uveal melanoma; Melanoma Details
Rezetamig JNJ-8780; JNJ75348780; JNJ-75348780 Phase 1 Clinical Teneobio Inc Lymphoma, B-Cell; Lymphoma, Non-Hodgkin; Leukemia, Lymphocytic, Chronic, B-Cell Details
Y-150(Wuhan Yzy Biopharma/CSPC Pharmaceutical) Y-150; Y150 Phase 1 Clinical Wuhan Yzy Biopharma Co Ltd, CSPC Pharmaceutical Group Ltd Multiple Myeloma Details
EX-101 EX-101; EX101 Phase 1 Clinical Guangzhou Excelmab Inc Solid tumours Details
Plamotamab XmAb-13676 Phase 1 Clinical Xencor Inc Lymphoma, B-Cell; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Leukemia, Lymphocytic, Chronic, B-Cell Details
A-337 A-337 Phase 1 Clinical Evive Biotech Ltd Solid tumours; Neoplasms Details
CCW-702 CCW-702 Phase 1 Clinical The Scripps Research Institute Inc, Abbvie Inc Prostatic Neoplasms Details
Tepoditamab MCLA-117 Phase 1 Clinical Pharmaceutical Research Associates, Institute Gustave-Roussy, Merus Nv, Vu University Medical Center, Lgc Leukemia, Myeloid, Acute Details
ERY-974 ERY-974 Phase 1 Clinical Chugai Pharmaceutical Co Ltd Solid tumours; Carcinoma, Hepatocellular Details
InHeAb-01 InHeAb-01; bsAB Clinical University Hospital Tuebingen Neoplasms Details

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