0
No hay productos en el carro de la compra
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 0-9
Your Position: Casa > MHC Clase I Servicio personalizado complejo

MHC Clase I Servicio personalizado complejo

MHC Clase I Servicio personalizado complejo
Antecedentes
El MHC I (complejo mayor de histocompatibilidad de clase I), también conocido como HLA en humanos, es un conjunto diverso de receptores de superficie celular que se expresan en todas las células nucleadas del organismo. Desempeña un papel crucial en el sistema inmunitario adaptativo. In vivo, el MHC I puede unirse a fragmentos de péptidos de antígenos de proteínas intactas. El complejo péptido-MHC es reconocido por los receptores antígeno-específicos de los linfocitos T, y tras el reconocimiento, las células T activadas contribuirán a la respuesta inmunitaria y ayuda a eliminar la infección.  Peptidoma del MHC I que permite respuestas altamente específicas mediadas por células T, de vital importancia para la inmunidad adaptativa. Por lo tanto, la investigación sobre la profunda relación entre el complejo péptido-MHC I y el TCR es cada vez más importante para la investigación del mecanismo y el desarrollo de fármacos.
Posicionado como un socio fiable para proporcionar reactivos claves para el descubrimiento y desarrollo de fármacos biológicos, ACROBiosystems puede proporcionar el servicio personalizado de complejo péptido-MHC I para acelerar su investigación pertinente.

Haga clic para personalizar

Características del servicio

Plataforma tecnológica profesional de I+D de complejos MHC-péptidos

Sistemas de expresión HEK 293

Existen varios tipos de MHC I y antígenos

Formas monómero/tetrámero

Las etiquetas FITC/PE/APC/Biotina son opcionales

Plataforma madura de verificación de la bioactividad: SPR/ELISA/FACS y más

Lista de productos personalizados
Alelo MHCObjetivo
HLA-A*0101 HLA-A*0201 HLA-A*0301 HLA-A*1101 HLA-A*2402  HLA-A*3303 HLA-B*1501 HLA-B*1525 HLA-B*3802 HLA-B*4601 HLA-B*0702 
       ……
NY-ESO-1  GP-100 MSLN AFP WT1 MAGE-A1 HPV HBV HIV EBV PRAME
       ……
Customized Product List

Haga clic para personalizar


Productos recomendados
MoléculaCat. No.EspeciesDescripción del productoPrepedido/pedido
HLA-A*0301 & B2MHLM-H82W6HumanBiotinylated Human HLA-A*03:01&B2M Complex Protein (Peptide free, MALS verified)

Order

HLA-C*0102 | B2MHLM-H82E8HumanBiotinylated Human HLA-C*01:02&B2M Complex Protein (Peptide free)

Preorder

HLA-C*0303 | B2MHLM-H82E9HumanBiotinylated Human HLA-C*03:03&B2M Complex Protein (Peptide free)

Preorder

HLA-A*02:01 & B2MHLM-H82W3HumanBiotinylated Human HLA-A*02:01&B2M Complex Protein (Peptide free, MALS verified)

Order

HLA-A*11:01 & B2MHLM-H82W5HumanBiotinylated Human HLA-A*11:01&B2M Complex Protein (Peptide free, MALS verified)

Order

HLA-A*0201 | B2M | EWHLE-H82E4HumanBiotinylated Human HLA-A*02:01&B2M&EW (QLQNPSYDK) Complex Protein (Monomer)

Order

HLA-A*0201 | B2M | AFPHLA-H82E3HumanBiotinylated Human HLA-A*02:01&B2M&AFP (FMNKFIYEI) Complex Protein (Monomer, MALS verified)

Order

HLA-A*0201 | B2M | HBVHLT-H82E9HumanBiotinylated Human HLA-A*02:01&B2M&HBV (FLLTRILTI) Complex Protein (Monomer, MALS verified)

Order

HLA-A*02:01 & B2M & WT-1HLW-H52E6HumanHuman HLA-A*02:01&B2M&WT-1 (RMFPNAPYL) Tetramer Protein (MALS verified)

Order

HLW-H82E5HumanBiotinylated Human HLA-A*02:01&B2M&WT-1 (RMFPNAPYL) Complex Protein (Monomer, MALS verified)

Order

HLA-A*02:01 & B2M & GP100HLG-H82E6HumanBiotinylated Human HLA-A*02:01&B2M&GP100 (YLEPGPVTA) Complex Protein (Monomer, MALS verified)

Order

HLA-A*0201 | B2M & HIV GagHLH-H82E8HumanBiotinylated Human HLA-A*02:01&B2M&HIV Gag (SLYNTVATL) Complex Protein (Monomer, MALS verified)

Order

HLA-A*0201 | B2M | MAGE-A4HLM-H82E5HumanBiotinylated Human HLA-A*02:01&B2M&MAGE-A4 (GVYDGREHTV) Complex Protein (Monomer, MALS verified)

Order

HLA-C*07:02:01 & B2M & RYRHLR-H52W2HumanBiotinylated Human HLA-C*07:02:01&B2M&RYR (RYRPGTVAL) Complex Protein (Monomer)

Order

HLA-A*0201 | B2M & CMV pp65HLC-H82E4HumanBiotinylated Human HLA-A*02:01&B2M&CMV pp65 (NLVPMVATV) Complex Protein (Monomer, MALS verified)

Order

HLA-A*0201 | B2M | HPV16-E6HLH-HP2H7HumanPE-Labeled Human HLA-A*02:01&B2M&HPV16-E6 (TIHDIILECV) Tetramer Protein

Order

HLA-A*0201 | B2M | NY-ESO-1HL1-HP2E5HumanPE-Labeled Human HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQC) Tetramer Protein

Preorder

HL1-HP2E6HumanPE-Labeled Human HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQV) Tetramer Protein

Preorder

HLA-A*0201 | B2M | RHAMM-R3HLR-H82E6HumanBiotinylated Human HLA-A*02:01&B2M&RHAMM-R3 (ILSLELMKL) Complex Protein (Monomer, MALS verified)

Order

HLA-A*02:01 & B2M & NY-ESO-1HL1-H52E7HumanHuman HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQV) Tetramer Protein (MALS verified)

Order

HL1-H52E8HumanHuman HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQC) Tetramer Protein (MALS verified)

Order

HL1-H82E4HumanBiotinylated Human HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQV) Complex Protein (Monomer, MALS verified)

Order

HL1-H82E6HumanBiotinylated Human HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQC) Complex Protein (Monomer, MALS verified)

Order

HLA-A*02:01 & B2M & Glycipan 3HLG-H52E5HumanHuman HLA-A*02:01&B2M&Glycipan 3 (FVGEFFTDV) Tetramer Protein (MALS verified)

Order

HLG-H82E4HumanBiotinylated Human HLA-A*02:01&B2M&Glycipan 3 (FVGEFFTDV) Complex Protein (Monomer, MALS verified)

Order

HLA-A*0301 | B2M | KRAS (VVGAGGVGK)HLS-H52H4HumanHuman HLA-A*03:01&B2M&KRAS (VVGAGGVGK) Complex Protein (Monomer)

Preorder

HLS-H82E5HumanBiotinylated Human HLA-A*03:01&B2M&KRAS (VVGAGGVGK) Complex Protein (Monomer)

Preorder

HLA-A*1101 | B2M | KRAS (VVGAGGVGK)HLS-H52H5HumanHuman HLA-A*11:01&B2M&KRAS (VVGAGGVGK) Complex Protein (Monomer)

Preorder

HLS-H82E3HumanBiotinylated Human HLA-A*11:01&B2M&KRAS (VVGAGGVGK) Complex Protein (Monomer)

Preorder

HLS-HA2H9HumanAlexa Fluor 647-Labeled Human HLA-A*11:01&B2M&KRAS (VVGAGGVGK) Complex ProteinStar Staining (Monomer)

Preorder

HLA-A*0201 | B2M & MAGE-A4 (KVLEHVVRV)HLP-H82E5HumanBiotinylated Human HLA-A*02:01&B2M&MAGE-A4 (KVLEHVVRV) Complex Protein (Monomer, MALS verified)

Order

HLA-A*02:01 & B2M & MAGE-A4 (KVLEHVVRV)HLK-H52E5HumanHuman HLA-A*02:01&B2M&MAGE-A4 (KVLEHVVRV) Tetramer Protein (MALS verified)

Order

HLA-A*0301 | B2M | KRASG12C (VVGACGVGK)HLC-H52H4HumanHuman HLA-A*03:01&B2M&KRASG12C (VVGACGVGK) Complex Protein (Monomer)

Preorder

HLC-H52H7HumanHuman HLA-A*03:01&B2M&KRASG12C (VVGACGVGK) Tetramer Protein

Preorder

HLC-H82E6HumanBiotinylated Human HLA-A*03:01&B2M&KRASG12C (VVGACGVGK) Complex Protein (Monomer)

Preorder

HLA-A*1101 | B2M | KRASG12D (VVGADGVGK)HLD-H52H4HumanHuman HLA-A*11:01&B2M&KRASG12D (VVGADGVGK) Complex Protein (Monomer)

Preorder

HLD-H52H8HumanHuman HLA-A*11:01&B2M&KRASG12D (VVGADGVGK) Tetramer Protein

Preorder

HLD-H82E5HumanBiotinylated Human HLA-A*11:01&B2M&KRASG12D (VVGADGVGK) Complex Protein (Monomer)

Preorder

HLD-HA2H7HumanAlexa Fluor 488-Labeled Human HLA-A*11:01&B2M&KRAS (VVGAGGVGK) Complex ProteinStar Staining (Monomer)

Preorder

HLA-A*1101 | B2M | KRASG12V (VVGAVGVGK)HLV-H52H3HumanHuman HLA-A*11:01&B2M&KRASG12V (VVGAVGVGK) Complex Protein (Monomer)

Preorder

HLV-H52H8HumanHuman HLA-A*11:01&B2M&KRASG12V (VVGAVGVGK) Tetramer Protein

Preorder

HLV-H82E6HumanBiotinylated Human HLA-A*11:01&B2M&KRASG12V (VVGAVGVGK) Complex Protein (Monomer)

Preorder

DATOS DE ENSAYO

Alta afinidad de unión verificada por SPR

Biotinylated Human HLA-A*02:01 NY-ESO-1

Anti-NY-ESO-1 antibody captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind Biotinylated Human HLA-A0201 NY-ESO-1 (SLLMWITQC) Complex Protein (Cat. No. HL1-H82E6) with an affinity constant of 16.9 nM as determined in a SPR assay (Biacore 8K) (QC tested).

Human HLA-A*02:01 NY-ESO-1

Anti-NY-ESO-1 antibody captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind Human HLA-A0201 NY-ESO-1 (SLLMWITQC) Tetramer Protein (Cat. No. HL1-H52E8) with an affinity constant of 1.35 nM as determined in a SPR assay (Biacore 8K) (QC tested).

Biotinylated Human HLA-C*07:02:01 & B2M & RYR

Biotinylated Human HLA-C*07:02:01 & B2M & RYR ,His,Avitag™&Tag Free (Cat. No. HLR-H52W2) immobilized on SA Chip can bind Human KIR2DL3, Fc Tag (Cat. No. KI3-H5258) with an affinity constant of 2.40 μM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Biotinylated Human HLA-C*07:02:01 & B2M & RYR

Biotinylated Human HLA-C*07:02:01 & B2M & RYR ,His,Avitag™&Tag Free (Cat. No. HLR-H52W2) immobilized on SA Chip can bind Human KIR2DL2, Fc Tag (Cat. No. KI2-H5255) with an affinity constant of 1.01 μM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Alta afinidad de unión verificada por ELISA

Biotinylated Human HLA-A*02:01 NY-ESO-1(SLLMWITQC)

Immobilized Biotinylated Human HLA-A*02:01 NY-ESO-1 (SLLMWITQC) Complex Protein (Cat. No. HL1-H82E6) at 1 μg/mL (100 μL/well) on streptavidin (Cat. No. STN-N5116) precoated (0.5 μg/well) plate can bind Anti-NY-ESO-1 Antibody, Human IgG1 with a linear range of 0.1-8 ng/mL (QC tested).

Biotinylated Human HLA-A*02:01 NY-ESO-1 (SLLMWITQV)

Immobilized Biotinylated Human HLA-A*02:01 NY-ESO-1 (SLLMWITQV) Complex Protein (Cat. No. HL1-H82E4) at 1 μg/mL (100 μL/well) on streptavidin (Cat. No. STN-N5116) precoated (0.5 μg/well) plate can bind Anti-NY-ESO-1 Antibody, Human IgG1 with a linear range of 0.2-16 ng/mL (QC tested).

Productos relacionados

Referencias

  • 1.Thomas C, Tampé R. MHC I assembly and peptide editing - chaperones, clients, and molecular plasticity in immunity. Curr Opin Immunol. 2021 Jun;70:48-56. doi: 10.1016/j.coi.2021.02.004. Epub 2021 Mar 6. PMID: 33689959.

  • 2.Becar M, Kasi A. Physiology, MHC Class I. 2021 Sep 28. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan–. PMID: 32310482.

ACRO Quality

This web search service is supported by Google Inc.

totop
Call us
Call us
North America:
+1 800-810-0816 (Toll Free)
Asia & Pacific:
+86 400-682-2521
Email
Correo electrónico
Fax
Fax
+1 888-377-6111
Address
Address
Lichtstrasse 35,4056 Basel, Switzerland

Dejar un mensaje