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Your Position: Casa > Antibody > Claudin-18.2 > HCS-S278

Recombinant Monoclonal Anti-Claudin-18.2 Antibody, Mouse (3B10)

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  • Background
    Recombinant Monoclonal Anti-Claudin-18.2 Antibody, Mouse (3B10) is a Claudin-18.2 primary antibody for IHC application. The Claudin-18.2 (CLDN 18.2) protein, an isoform of Claudin 18, a member of the tight junction protein family, is a highly selective biomarker with limited expression in normal tissues and often abnormal expression during the occurrence and development of various primary malignant tumors, such as gastric cancer/gastroesophageal junction (GC/GEJ) cancer, breast cancer, colon cancer, liver cancer, head and neck cancer, bronchial cancer and non-small-cell lung cancer. Claudin-18.2 participates in the proliferation, differentiation and migration of tumor cells. Recent studies have identified Claudin-18.2 expression as a potential specific marker for the diagnosis and treatment of these tumors.
  • Key parameter
    Host SpeciesMouse
    IsotypeIgG
    Clone3B10
    ApplicationIHC
    Property1:1000
    StateLiquid
    Positive ControlHuman Stomach Tissues
    ClonalityMonoclonal
    Research FieldCancer Drug Targets
    SourceMouse
    SynonymClaudin18.2, CLDN 18.2
  • Experiment Protocol
  • Storage
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. The shelf life is 30 days from the date of opening.
Typical Data
Control Sample
 Claudin-18.2 CONTROL SAMPLE

Immunohistochemical analysis of paraffin embedded human stomach tissue labelled with HCS-S278 at 1/1000 dilution.
Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.

 Claudin-18.2 CONTROL SAMPLE

Immunohistochemical analysis of paraffin-embedded human lung tissue labeling Claudin-18.2 with HCS-S278 at 1/1000 dilution, followed by Goat Anti-Mouse IgG H&L (HRP) ready to use. The staining in the lung tissue sample was negative. Counter stained with Hematoxylin. Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.

Cancer Sample
 Claudin-18.2 CANCER SAMPLE Claudin-18.2 CANCER SAMPLE

Immunohistochemical analysis of paraffin-embedded human cancer tissue labeling Claudin-18.2 with HCS-S278 at 1/1000 dilution, followed by Goat Anti-Mouse IgG H&L (HRP) ready to use. Membranous staining on tumor cells is observed. Counter stained with Hematoxylin. Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.

  • Clinical and Translational Updates

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ETA de productos en stock: 2 días laborables

Price(USD) : $255.00

Price(USD) : $850.00

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Drug Development Status

  • Number of Launched Drugs:1 Details
  • Number of Drugs in Clinical Trials:69 Details
  • Latest Research Phase:Phase 3 Clinical

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