Acrobiosystems for English
icon_bulk_orderConsulta masiva/Pedido rápido
user
  1. Cuadro de mandos
  2. Mi perfil
  3. Mi dirección
  4. Mis pedidos
  5. Afiliación a Acro
Iniciar sesión Registro
Promotion
Recombinant Proteins ClearClear history
Recombinant Proteins CloseClose
Browse Products By Molecule Name a-zA-Z
TL1A Hot |GMP IL-2 Hot |FcRn Binding Kit (TR-FRET) New |Claudin 18.2
0
No hay productos en el carro de la compra
Mi carro|Check Out
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 0-9
Your Position: Casa > IL-31

IL-31

Brief Information

Name:Interleukin-31
Target Synonym:Interleukin 31,IL-31
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Phase 1 Clinical

Product ListCompare or Buy

Product> Filter Results
Por estado del producto :
Por categoría de producto :
Por especies :
Por etiqueta :
Por Conjugado::
Cat. No. Especies Descripción del producto Estructura Pureza Característica
IL1-H82E6 Human Biotinylated Human IL-31 Protein, His,Avitag™ (MALS verified)
IL1-H82E6-structure
IL1-H82E6-sds
IL1-H5219 Human Human IL-31 Protein, premium grade
IL1-H5219-structure
IL1-H5219-sds
IL1-M82Q9 Mouse Biotinylated Mouse IL-31 Protein, His,Avitag™ (MALS verified)
IL1-M82Q9-structure
IL1-M82Q9-sds
IL1-C5245 Cynomolgus Cynomolgus IL-31 Protein, His Tag
IL1-C5245-structure
IL1-C5245-sds
IL1-H5247 Human Human IL-31 Protein, His Tag (MALS verified)
IL1-H5247-structure
IL1-H5247-sds
ACRO Quality

Part of Bioactivity data

IL1-H5247-SPR
IL-31 SPR

Human IL-31, His Tag (Cat. No. IL1-H5247) immobilized on CM5 Chip can bind Human IL-31 RA, His Tag (Cat. No. ILA-H52H7) with an affinity constant of 52.1 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Protocol
IL1-H5247-SPR
IL-31 SPR

Human IL-31, His Tag (Cat. No. IL1-H5247) capture on NTA-Series S sensor chip can bind Human IL-31 RA, Fc Tag (Cat. No. ILA-H5256) with an affinity constant of 37.1 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Protocol

Synonym Name

IL-31,IL31,Interleukin-31

Background

IL-31 is an inflammatory cytokine that helps trigger cell-mediated immunity against pathogens. Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR. It has also been identified as a major player in a number of chronic inflammatory diseases, including atopic dermatitis. May function in skin immunity. IL-31 is produced by a variety of cells, namely type 2 helper (TH2) T-cells. IL-31 sends signals through a receptor complex made of IL-31RA and oncostatin M receptor β (OSMRβ) expressed in immune and epithelial cells. These signals activate three pathways: ERK1/2 MAP kinase, PI3K/AKT, and JAK1/2 signaling pathways.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
NM26-2198 NM-26-2198 Phase 1 Clinical Kaken Pharmaceutical Co Ltd, Numab Therapeutics Ag Inflammation; Dermatitis, Atopic Details
NM26-2198 NM-26-2198 Phase 1 Clinical Kaken Pharmaceutical Co Ltd, Numab Therapeutics Ag Inflammation; Dermatitis, Atopic Details

This web search service is supported by Google Inc.

totop
Call us
Call us

Germany+49 800 0826645

United Kingdom+44 808 281 3436

Netherlands+31 800 0224992

Switzerland+41 800 040 012

France+33 800 90 78 85

Sweden+46 20 12 76 94

Denmark+45 80 83 07 62

Belgium+32 800 27 125

Email
Correo electrónico
order@acrobiosystems.com
Fax
Fax
+1 888-377-6111
Address
Address
Lichtstrasse 35,4056 Basel, Switzerland
linkedin twitter facebook youtube

Dejar un mensaje

Copyright © 2017 ACROBiosystems. All Rights Reserved
Related Links|Privacy Policy|Terms and Conditions|Legal|Sitemap