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Your Position: Casa > Protein > MBL > MBL-H5220

Human MBL Protein, His Tag

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  • Synonym
    MBL,MBL2,MBP1,MBP-C,Collectin-1,COLEC1,HSMBPC,MBL2D,MBPD
  • Source
    Human MBL, His Tag(MBL-H5220) is expressed from human 293 cells (HEK293). It contains AA Glu 21 - Ile 248 (Accession # P11226-1).
    Predicted N-terminus: Glu 21
  • Molecular Characterization
    MBL Structure

    This protein carries a polyhistidine tag at the C-terminus

    The protein has a calculated MW of 25.9 kDa. The protein migrates as 30-38 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >95% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
MBL SDS-PAGE

Human MBL, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95% (With Star Ribbon Pre-stained Protein Marker).

  • Background
    Mannose-binding lectin (MBL) is also known as mannose-binding protein, mannan-binding protein (MBP), Mannose-binding protein C, Collectin-1 (COLEC1), MBL2, which belongs to the class of collectins in the C-type lectin superfamily. MBL contains one C-type lectin domain and one collagen-like domain. MBL has an oligomeric structure (400-700 kDa), built of subunits that contain three presumably identical peptide chains of about 30 kDa each. MBL is calcium-dependent lectin involved in innate immune defense. MBL binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. MBL binds to late apoptotic cells. MBL may bind D.
  • Clinical and Translational Updates

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Price(EUR) : €250.00

Price(EUR) : €1670.00

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Drug Development Status

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  • Number of Drugs in Clinical Trials:0 Details
  • Latest Research Phase:Discontinued

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