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Salt Active GENIUS™Nuclease, premium grade is designed for preclinical stage, has more comprehensive QC testing (such as HCP and so on) and tighter specifications based on the following GENIUS features.
Salt Active GENIUS™Nuclease, premium grade has the same activity and performance with GMP Grade Salt Active Nuclease, which enables a seamless transition from preclinical development to clinical phases. By using Salt Active GENIUS™Nuclease, premium grade in your development phase you can easily transit into clinical and commercial phases and avoid needing to amend your manufacturing process and undertake comparability studies.
Elimination of nucleic acids from biologics, suitable for samples with 0-500 mM salt in presence of 5-10 mM Mg++
• viral vaccine development process
• viral vector development process for cell and gene therapy (CGT)
• Other biologics development processes
>95% as determined by SDS-PAGE.
>95% as determined by SEC-HPLC.
Supplied as 0.2 μm filtered solution in 25 mM Tris, 500 mM NaCl, 5 mM MgCl2, pH7.5 with glycerol as protectant.
Contact us for customized product form or formulation.
This product is supplied and shipped with dry ice, please inquire the shipping cost.
This product is stable after storage at:
The gel was stained with Coomassie Blue. The purity of the protein is greater than 95% (With Star Ribbon Pre-stained Protein Marker).
The purity of Salt Active GENIUSNuclease, premium grade (Cat. No. NUE-S5117) was greater than 95% as determined by SEC-HPLC.
Specific activity for Salt Active GENIUS™Nuclease, premium grade is measured under standard assay conditions. The specific activity of Salt Active GENIUS™Nuclease, premium grade is >4.3E+05 unit/mg at 500 mM salt concentration (QC tested). One unit will digest sonicated salmon sperm DNA to acid-soluble oligonucleotides equivalent to a ΔA260 of 1.0 in 30 min at pH 8.0 at 37 °C, which corresponds approximately to complete digestion of 37 μg DNA (QC tested).
Specific activity of Salt Active GENIUS™Nuclease, premium grade at different salt concentrations.
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