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Your Position: Casa > Protein > Activin RIB & Activin RIIB > ACB-H5253

Human Activin RIB & Activin RIIB Protein, Fc Tag&Fc Tag

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  • Synonym
    ACTRIIB, ActR-IIB, HTX4
  • Source
    Human Activin RIB & Activin RIIB Protein, Fc Tag&Fc Tag(ACB-H5253) is expressed from human 293 cells (HEK293). It contains AA Gly 25 - Glu 126 & Gly 20 - Pro 133 (Accession # P36896-1 & Q13705-1).
  • Molecular Characterization
    Activin RIB & Activin RIIB Structure

    The protein has a calculated MW of 37 kDa & 39.1 kDa. The protein migrates as 80-95 kDa and >150 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >90% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Activin RIB & Activin RIIB SDS-PAGE

Human Activin RIB & Activin RIIB Protein, Fc Tag&Fc Tag on SDS-PAGE under non-reducing (NR) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

Bioactivity-ELISA
 Activin RIB & Activin RIIB ELISA

Immobilized Human Activin A Protein, Tag Free (Cat. No. ACA-H421b) at 5 μg/mL (100 μL/well) can bind Human Activin RIB & Activin RIIB Protein, Fc Tag&Fc Tag (Cat. No. ACB-H5253) with a linear range of 0.3-10 ng/mL (QC tested).

 Activin RIB & Activin RIIB ELISA

Immobilized Human latent GDF-8, His Tag (Cat. No. GD8-H5243) at 5 μg/mL (100 μL/well) can bind Human Activin RIB & Activin RIIB Protein, Fc Tag&Fc Tag (Cat. No. ACB-H5253) with a linear range of 0.005-0.156 μg/mL (Routinely tested).

  • Background
    Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor.
  • Clinical and Translational Updates

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ETA de productos en stock: 2 días laborables

Price(EUR) : €350.00

Price(EUR) : €2330.00

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