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Your Position: Casa > Protein > Cadherin-17 > CA7-R52H3

Rat Cadherin-17 / CDH17 Protein, His Tag (MALS verified)

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  • Synonym
    Cadherin-17,CDH17,HPT-1, LI-cadherin
  • Source
    Rat Cadherin-17 Protein, His Tag(CA7-R52H3) is expressed from human 293 cells (HEK293). It contains AA Gln 22 - Met 786 (Accession # P55281-1).
    Predicted N-terminus: Gln 22
  • Molecular Characterization
    Cadherin-17 Structure

    This protein carries a polyhistidine tag at the C-terminus

    The protein has a calculated MW of 86.9 kDa. The protein migrates as 100-115 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >90% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in 20 mM Tris, 150 mM NaCl, pH8.0 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Cadherin-17 SDS-PAGE

Rat Cadherin-17 Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90%.

SEC-MALS
Cadherin-17 MALS images

The purity of Rat Cadherin-17 Protein, His Tag (Cat. No. CA7-R52H3) is more than 85% and the molecular weight of this protein is around 95-120 kDa verified by SEC-MALS.

  • Background
    Cadherin-17, also known as liver-intestine (LI) Cadherin, belongs to the cadherin family of calcium-dependent cell adhesion molecules. In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach.
  • Clinical and Translational Updates

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Price(EUR) : €400.00

Price(EUR) : €2830.00

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  • Number of Drugs in Clinical Trials:3 Details
  • Latest Research Phase:Phase 2 Clinical

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