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Limited Edition Golden Llama is here! Check out how you can get one. Limited Edition Golden Llama is here! Check out how you can get one.
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Assay Type | Sandwich-ELISA |
Analyte | IL-6 |
Format | 96T |
Reactivity | Human |
Regulatory Status | RUO |
Sensitivity | < 2.34 pg/mL |
Standard Curve Range | 2.34 pg/mL-150 pg/mL |
Assay Time | 2 hr 50 min |
Suitable Sample Type | For the quantitative determination of human IL-6 in Cell Culture Supernatants, Plasma, Serum. |
Sample volume | 100 uL |
ID | Components | Size |
CRS005-C01 | Pre-coated Anti-IL-6 Antibody Microplate | 1 plate |
CRS005-C02 | Human IL-6 Standard | 20 μg |
CRS005-C03 | Biotin-Anti-IL-6 Antibody | 50 μL |
CRS005-C04 | Streptavidin-HRP | 50 μL |
CRS005-C05 | 10xWashing Buffer | 50 mL |
CRS005-C06 | 2xDilution Buffer | 50 mL |
CRS005-C07 | Substrate Solution | 12 mL |
CRS005-C08 | Stop Solution | 7 mL |
Human Interleukin-6 (IL-6) ELISA Kit (Residue Testing) was developed for the detection and quantitative determination of GMP human IL-6 in samples from CAR-T product preparation processing.
It is for research use only.
Find the expiration date on the outside packaging and do not use reagents past their expiration date.
The opened kit should be stored per components table. The shelf life is 30 days from the date of opening.
Your experiment will include 6 simple steps:
a) Bring all reagents to room temperature(20℃-25℃) before use.
b) Add your sample to the plate and take the Human IL-6 as standard. The samples and standard are diluted by Dilution Buffer.
c) Wash the plate and add the Biotin-Anti-IL-6 Antibody diluted by Dilution Buffer to the plate.
d) Wash the plate and add the Streptavidin-HRP diluted by Dilution Buffer to the plate.
e) Wash the plate and add TMB.
f) Stop the substrate reaction by adding diluted acid. Absorbance (OD) is calculated by the absorbance at 450 nm minus the absorbance at 630 nm to remove background disturbance before statistical analysis. The OD Value reflects the amount of bound protein.
For each experiment, a standard curve needs to be set for each micro-plate, and the specific OD value may vary depending on different laboratories, testers, or equipments. The following example data is for reference only.
To assess the linearity of the assay, samples spiked with high concentrations of human IL-6 were serially diluted with calibrator diluent to produce samples with values within the dynamic range of the assay.
Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision, Intra-Assay Precision CV<10%.
Three samples of known concentration were tested in three separate assays to assess inter-assay precision, Inter-Assay Precision CV<10%.
Three parts of blank serum were added with different concentrations of human IL-6, and the serum without human IL-6 was used as background to calculate the recovery rate. The range of the recovery rate is 90.6-114.8%, and the average recovery is 101.2%.
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English Name | Research Code | Research Phase | Company | First Brand Name | First Approved Country | First Indication | First Approved Company | First Approved Fecha | Indications | Clinical Trials |
---|---|---|---|---|---|---|---|---|---|---|
Lenalidomide | IMID-5013; CDC-5013; CDC-501; CC-5013; IMiD-3; ENMD-0997; STAR-LLD | Approved | Celgene Corp | Revimid (former Brand Name), 瑞复美, Revlimid, Leavdo | United States | Myelodysplastic Syndromes | Bristol Myers Squibb Srlcompany | 2005-12-27 | Lymphoma, T-Cell, Peripheral; Optic Nerve Glioma; Intestinal Neoplasms; Immunoproliferative Small Intestinal Disease; Solid tumours; Bone Marrow Neoplasms; Lymphoma, B-Cell, Marginal Zone; Kidney Neoplasms; Leukemia; Liver Neoplasms; Hematologic Diseases; Leukemia, Erythroblastic, Acute; Leukemia, Promyelocytic, Acute; Leukemia, Myeloid; Ependymoma; HIV Infections; Ovarian Neoplasms; Medulloblastoma; Leukemia, Hairy Cell; Anemia; Paraproteinemias; Pain; Polycythemia Vera; Plaque, Amyloid; Rhabdoid Tumor; Anemia, Refractory, with Excess of Blasts; Glioblastoma; Smoldering Multiple Myeloma; Anemia, Refractory; Lymphoma, Large B-Cell, Diffuse; Hodgkin Disease; Myelodysplastic Syndromes; Hypothalamic Neoplasms; Neoplasms; Leukemia-Lymphoma, Adult T-Cell; Plasmacytoma; Blood Protein Disorders; Graft vs Host Disease; Leukemia, Myelomonocytic, Chronic; Leukemia, Myelomonocytic, Acute; Nerve Degeneration; Lymphomatoid Granulomatosis; Pancreatic Neoplasms; Multiple Myeloma; Leukemia, Megakaryoblastic, Acute; Oligodend | Details |
Luminol sodium | MP-1032 | Approved | Selvim, Metrio | Immune System Diseases; Psoriasis | null | 1997-01-01 | Coronavirus Disease 2019 (COVID-19); Immune System Diseases; Psoriasis | Details | ||
Pomalidomide | IMID-4047; CDC-394; CC-4047; IMiD-1 | Approved | Celgene Corp | Pomalyst, Imnovid, Actimid, Pomalyst/Imnovid, 安跃 | United States | Multiple Myeloma | Bristol-Myers Squibb Company | 2013-02-08 | Pulmonary Fibrosis; Atypical Squamous Cells of the Cervix; Sarcoma, Kaposi; Anemia, Sickle Cell; Neurofibromatosis 1; Lymphoma, Non-Hodgkin; Carcinoma, Small Cell; Waldenstrom Macroglobulinemia; Glioma; Primary Myelofibrosis; Sarcoma; Thrombocytosis; Prostatic Neoplasms; Lung Diseases, Interstitial; Medulloblastoma; Central Nervous System Neoplasms; Multiple Myeloma; Hodgkin Disease; Plasmacytoma; Kidney Diseases; Pancreatic Neoplasms; Immunoglobulin Light-chain Amyloidosis; Myeloproliferative Disorders; Graft vs Host Disease; Scleroderma, Systemic; Polycythemia Vera; Bone Marrow Neoplasms; Solid tumours | Details |
Siltuximab | cCLB-8; CNTO-328 | Approved | Johnson & Johnson | Sylvant | United States | Multicentric Castleman's Disease (MCD) | Janssen Biotech Inc | 2014-04-23 | Psychotic Disorders; Leukemia, Large Granular Lymphocytic; Lymphoma, Non-Hodgkin; Lung Neoplasms; Thrombocytopenia; Colorectal Neoplasms; Castleman Disease; Primary Myelofibrosis; Prostatic Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Neoplasms, Plasma Cell; Multicentric Castleman's Disease (MCD); Lung Diseases; Monoclonal Gammopathy of Undetermined Significance; Respiratory Distress Syndrome, Adult; Multiple Myeloma; Bone Marrow Neoplasms; Immunoglobulin Light-chain Amyloidosis; Myelodysplastic Syndromes; Pancreatic Neoplasms; Smoldering Multiple Myeloma; Respiratory Tract Diseases; Schizophrenia; Pneumonia; Carcinoma, Renal Cell; Polycythemia Vera; Kidney Neoplasms; Respiratory Tract Infections; Cytokine Release Syndrome; Head and Neck Neoplasms; Ovarian Neoplasms; Diabetes Mellitus, Type 1 | Details |
Andrographolide/Sodium Hydrogen Sulfite | Approved | Bacterial Infections | Details | |||||||
Thalidomide | NSC-66847; NSC-527179; K-17; VP-02; FPF-300; FPF300 | Approved | Celgene Corp | Talizer, Thalidomide Celgene, Thalidomide Pharmion, Synovir, Thalomid, Thaled | Mainland China | Leprosy, Lepromatous; Multiple Myeloma | Changzhou Pharmaceutical Factory | 1982-01-01 | HIV Wasting Syndrome; Angiodysplasia; Primary Myelofibrosis; Neuroectodermal Tumors, Primitive; Prostatitis; Colorectal Neoplasms; Osteosarcoma; Lymphoma, Mantle-Cell; Sarcoma, Ewing; Retinoblastoma; Erythema Nodosum; Drug Resistant Epilepsy; Xerostomia; Sarcoma; Pancreatitis, Chronic; Adenocarcinoma, Clear Cell; Lymphoma, Follicular; Arachnoiditis; Carcinoma, Adenosquamous; Gastrointestinal Hemorrhage; Cholangitis, Sclerosing; Prostatic Neoplasms; Pelvic Pain; Neoplasm Metastasis; Stomatitis; Burning Mouth Syndrome; Mycobacterium avium-intracellulare Infection; Amyotrophic Lateral Sclerosis; Melanoma; Myelodysplastic-Myeloproliferative Diseases; Carcinoma, Hepatocellular; Leukemia, Lymphocytic, Chronic, B-Cell; Vascular Malformations; Tuberculosis; Appendiceal Neoplasms; Lymphoma, Non-Hodgkin; Uterine Neoplasms; Anemia, Sideroblastic; Glioma; Leprosy, Lepromatous; Endometrial Neoplasms; Lung Neoplasms; Waldenstrom Macroglobulinemia; Kidney Neoplasms; Thalassemia; Carcinoid Tumor; Lupus Erythematosus, Discoid | Details |
English Name | Research Code | Research Phase | Company | Indications | Clinical Trials |
---|---|---|---|---|---|
Ensereptide | PXL-01 | Phase 3 Clinical | Promore Pharma | Post-surgical adhesions; Tissue Adhesions; Cicatrix | Details |
Olokizumab | CDP-6038; Anti-IL6-UCB | Phase 3 Clinical | Ucb | Arthritis, Rheumatoid; Coronavirus Disease 2019 (COVID-19); Arthritis; Crohn Disease | Details |
Efprezimod alfa | CD24-Fc; HAS-CD24; CD24-Fc-IgG; MK-7110; MK7110 | Phase 3 Clinical | Oncoimmune Inc | Solid tumours; Hematopoietic stem cell transplantation (HSCT); Leukemia; HIV Infections; Graft vs Host Disease; Myelodysplastic Syndromes; Coronavirus Disease 2019 (COVID-19); Precursor Cell Lymphoblastic Leukemia-Lymphoma; Dyslipidemias; Leukemia, Myeloid, Acute; Melanoma | Details |
Ziltivekimab | COR-001 | Phase 3 Clinical | Astrazeneca Plc | Myocardial Infarction; Heart Failure; Anemia; Atherosclerosis; Cardiovascular Diseases; Inflammation; Renal Insufficiency, Chronic; Systemic Inflammatory Response Syndrome | Details |
Clazakizumab | ALD-518; ALD518-003; BMS-645429; BMS-945429 | Phase 3 Clinical | Alder Biopharmaceuticals | Plaque, Atherosclerotic; Arthritis, Rheumatoid; Fatigue; Coronavirus Disease 2019 (COVID-19); Graft vs Host Disease; Rejection of organ transplantation; Arthritis, Psoriatic; Asthma; Cachexia; Crohn Disease; Carcinoma, Non-Small-Cell Lung; Kidney Failure, Chronic; Stomatitis | Details |
RO-7200220 | RO-7200220 | Phase 3 Clinical | F. Hoffmann-La Roche Ltd | Macular Edema; Diabetic macular oedema | Details |
PF-04236921 | PF-4236921; PF-04236921; TOUR006; TOUR-006 | Phase 2 Clinical | Pfizer Inc | Arthritis, Rheumatoid; Graves Ophthalmopathy; Lupus Erythematosus, Systemic; Renal Insufficiency, Chronic; Crohn Disease | Details |
Sirukumab | BA-003; CNTO-136 | Phase 2 Clinical | Glaxosmithkline Plc, Johnson & Johnson Innovative Medicine | Giant Cell Arteritis; Depressive Disorder, Major; Arthritis, Rheumatoid; Lupus Erythematosus, Cutaneous; Coronavirus Disease 2019 (COVID-19); Lupus Nephritis; Polymyalgia Rheumatica; Lupus Erythematosus, Systemic; Asthma | Details |
KSI-501 | KSI-501 | Phase 2 Clinical | Kodiak Sciences Inc | Retinal Diseases; Wet Macular Degeneration; Diabetic macular oedema; Uveitis | Details |
Anti-interleukin-6 receptor monoclonal antibody (Biocad) | Phase 2 Clinical | Biocad | Autoimmune Diseases | Details | |
Isomyosamine | MYMD-1 | Phase 2 Clinical | Mymd Pharmaceuticals Inc | Depression; Anxiety; Hashimoto Disease; Frailty; Coronavirus Disease 2019 (COVID-19); Arthritis, Rheumatoid; Healthy Aging; Inflammation; Sarcopenia | Details |
FB-704A | FB-704; FB-704A | Phase 2 Clinical | Fountain Biopharma Inc | Arthritis, Rheumatoid; Asthma | Details |
Gerilimzumab | GB-224; RYI-008; ARGX-109 | Phase 1 Clinical | Argenx Se | Arthritis, Rheumatoid | Details |
RG-6179 | RG-6179 | Phase 1 Clinical | F. Hoffmann-La Roche Ltd | Diabetic macular oedema | Details |
MEDI-5117 | WBP-216; MEDI-5117 | Phase 1 Clinical | Wuxi Apptec Co Ltd, Medimmune | Arthritis, Rheumatoid | Details |
Tocilizumab biosimilar (Mycenax Biotech) | Phase 1 Clinical | Mycenax Biotech Inc | Arthritis, Rheumatoid | Details | |
NEX-20A | NEX-20A | Phase 1 Clinical | Nanexa AB | Multiple Myeloma | Details |
Wogonin | Shandong Buchang Pharmaceuticals Co Ltd, Hefei Cosource Medicine Technology, Daewoong Pharmaceutical Co Ltd, China Pharmaceutical University | Details |
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