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Limited Edition Golden Llama is here! Check out how you can get one. Limited Edition Golden Llama is here! Check out how you can get one.
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It is for research use only.
Your experiment will include 4 simple steps:
1. Coat the plate with human CD47.
2. Mix biotinylated human SIRP alpha and your molecule of interest.
3. Add to the coated human CD47.
4. Add Streptavidin-HRP followed by TMB or other colorimetric HRP substrate.
Finally, the ability of your compound to inhibit CD47: SIRP alpha binding will be determined by comparing OD readings among different experimental groups.
INHIBITION OF CD47: SIRP ALPHA [BIOTINYLATED] BINDING BY ANTI-CD47 NEUTRALIZING ANTIBODY
Serial dilutions of anti-CD47 neutralizing antibody (Catalog # CD7-NA002) (1:2 serial dilutions, from 10 μg/mL to 0.04 μg/mL or 66.67 nM to 0.26 nM) was added into CD47: biotinylated SIRP alpha binding reactions. Background was subtracted from data points prior to log transformation and curve fitting (QC tested).
Explore our catalog of therapeutic antibody solutions to find the right products for you! We are dedicated to delivering solutions designed to help you drive innovation and push the boundaries of what therapeutic antibodies can be.
We offer a wide range of cell and gene therapy solutions starting from discovery to the clinic. Explore our wide range of proteins, antibodies, kits, and other assays to accelerate the development of your cell and gene therapy.
Organoid Toolbox is a collection of organoid solutions including ready-to-use organoids, organoid differentiation kits, and a variety of services to accelerate the progress of your drug development project.
ACROBiosystems developed a series of GMP grade cytokines under the GMP grade quality management system. Those products are all suitable for T/NK cell generation, activation, and proliferation in cell therapy research.
50+ targets designed for CAR detection, including PE/FITC/biotin labeled proteins. The key reagents for CD19 and BCMA were FDA DMF filed which can support your IND, NDA and BLA process.
GMP grade cytokines, reagents for cell activation, gene edition, DNA/RNA removal, etc. Particularly focus on product design, quality control and solution-based support to link each phase of your cell and gene therapy journey.
Full length multi-pass TPs with stabilized structure and high bioactivity for immunization, antibody screening, cell based assay and CAR detection, including hot CD20, Claudin 18.2, CD133, GPRC5D,CCR8, CCR5, etc.
A series of immune checkpoints including classic co-inhibitory and co-stimulatory receptors. The comprehensive catalog contains 100+ targets with various species and tags, and the high-quality proteins are in good batch-to-batch consistency.
To meet the needs of ADCs development, ACROBiosystems can provide: A variety of high-quality target proteins; MMPs/Cathepsin/uPA for cleavable linker; Anti-payload antibodies & anti-idiotypic antibodies for immunogenicity and PK analysis; SPR/BLI analytical and ADA development service.
Comprehensive collection of Fc receptor proteins, including their common variants, which can help expedite your antibody development.
Comprehensive cytokine targets including interleukins, growth factors, chemokines, TNFs, etc. are expressed by HEK293 to ensure their natural structure. Their high purity is verified by SDS-PAGE/HPLC/SEC-MALS and high bioactivity is verified by ELISA/SPR/BLI.
Aneuro provides innovative solutions for neuroscience research. Recombinant proteins, neural factors, pre-formed fibrils, electrophysiological electrodes, as well as Organoid Toolbox all in Aneuro aiming to advance neuroscience research, develop therapeutic interventions, and improve diagnostic methods for neurological diseases.
English Name | Research Code | Research Phase | Company | First Brand Name | First Approved Country | First Indication | First Approved Company | First Approved Fecha | Indications | Clinical Trials |
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English Name | Research Code | Research Phase | Company | Indications | Clinical Trials |
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Evorpacept | ALX148; ALX-148 | Phase 3 Clinical | Alexo Therapeutics | Urinary Bladder Neoplasms; Neoplasm Metastasis; Lymphoma; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Colorectal Neoplasms; Primary mediastinal B cell lymphoma; Richter's Syndrome; Lymphoma, Mantle-Cell; Lymphoma, Follicular; Plasmablastic Lymphoma; Solid tumours; Carcinoma, Transitional Cell; Composite Lymphoma; Neoplasms; Myelodysplastic Syndromes; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Esophageal Neoplasms; Lymphoma, B-Cell, Marginal Zone; Lymphoma, B-Cell; Head and Neck Neoplasms | Details |
Lemzoparlimab | TJC-4; ABBV-IMAB-TJC4; TJ-1133; TJ-011133 | Phase 3 Clinical | I-Mab Biopharma Co Ltd, Abbvie Inc | Solid tumours; Hematologic Neoplasms; Myelodysplastic Syndromes; Multiple Myeloma; Leukemia, Myeloid, Acute; Lymphoma | Details |
Magrolimab | 5-F-9; Hu5F9-G4; ONO-7913 | Phase 2 Clinical | Stanford University | Urinary Bladder Neoplasms; Mycosis Fungoides; Lymphoma, Non-Hodgkin; Lymphoma, T-Cell, Cutaneous; Leukemia, Myeloid, Acute; Sezary Syndrome; Colorectal Neoplasms; Lymphoma, Follicular; Lymphoma, Mantle-Cell; Osteosarcoma; Neuroblastoma; Brain Neoplasms; Multiple Myeloma; Solid tumours; Triple Negative Breast Neoplasms; Myelodysplastic Syndromes; Hodgkin Disease; Lymphoma, Large B-Cell, Diffuse; Carcinoma, Transitional Cell; Leukemia, Lymphoid; Squamous Cell Carcinoma of Head and Neck; Lymphoma, B-Cell, Marginal Zone; Leukemia, Myeloid; Ovarian Neoplasms; Lymphoma, B-Cell | Details |
Timdarpacept | IMM01; IMM 01 | Phase 2 Clinical | ImmuneOnco Biopharmaceuticals (Shanghai) Co Ltd | Solid tumours; Leukemia, Promyelocytic, Acute; Myelodysplastic Syndromes; Hodgkin Disease; Multiple Myeloma; Lymphoma, Extranodal NK-T-Cell; Leukemia, Myeloid, Acute; Lymphoma; Lymphoma, Non-Hodgkin | Details |
AO-176 | AO-176; Ti-104; Ti-108; Ti-176 | Phase 2 Clinical | Arch Oncology Inc | Solid tumours; Multiple Myeloma | Details |
Ontorpacept | TTI-621 | Phase 2 Clinical | The Hospital For Sick Children, University Health Network, Trillium Therapeutics Inc | Multiple Myeloma; Mycosis Fungoides; Melanoma; Carcinoma, Squamous Cell; Lymphoma, Non-Hodgkin; Lymphoma, T-Cell; Sarcoma; Breast Neoplasms; Primary mediastinal B cell lymphoma; Lymphoma, Follicular; Leiomyosarcoma; Neoplasms; Papillomavirus Infections; Skin Neoplasms; Lymphoma, Large B-Cell, Diffuse; Carcinoma, Merkel Cell; Hematologic Neoplasms; Solid tumours; Lymphoma, B-Cell | Details |
IMM-0306 | IMC-002; IMM-0306 | Phase 2 Clinical | ImmuneOnco Biopharmaceuticals (Shanghai) Co Ltd | Lymphoma, B-Cell; Lymphoma, Non-Hodgkin | Details |
Ligufalimab | AK-117 | Phase 2 Clinical | Zhongshan Akeso Biopharma Co Ltd | Solid tumours; Esophageal Neoplasms; Stomach Neoplasms; Squamous Cell Carcinoma of Head and Neck; Neoplasms; Myelodysplastic Syndromes; Triple Negative Breast Neoplasms; Breast Neoplasms; Leukemia, Myeloid, Acute; Lymphoma | Details |
Maplirpacept | TTI-622; PF-07901801 | Phase 2 Clinical | Trillium Therapeutics Inc | Hematologic Neoplasms; Ovarian Neoplasms; Lymphoma, B-Cell; Lymphoma, Large B-Cell, Diffuse; Carcinoma, Ovarian Epithelial; Skin Neoplasms; Multiple Myeloma; Lymphoma, Follicular; Primary mediastinal B cell lymphoma; Peritoneal Neoplasms; Lymphoma; Fallopian Tube Neoplasms; Lymphoma, Non-Hodgkin; Lymphoma, T-Cell; Leukemia, Myeloid, Acute | Details |
DSP-107 | DSP-107; KAHR-107 | Phase 2 Clinical | Kahr Medical | Solid tumours; Leukemia, Myelomonocytic, Chronic; Myelodysplastic Syndromes; Colorectal Neoplasms; Leukemia, Myeloid, Acute; Carcinoma, Non-Small-Cell Lung | Details |
LB-101 (Centessa Pharmaceuticals) | LB-101 (Centessa Pharmaceuticals); LB-101 Tetravalent PD-L1xCD47 LockBody bispecific monoclonal antibody | Phase 2 Clinical | Centessa Pharmaceuticals Plc | Solid tumours | Details |
ISB-1442 | ISB 1442; ISB-1442 | Phase 2 Clinical | Ichnos Sciences Sa | Multiple Myeloma; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Leukemia, Myeloid, Acute | Details |
PT-886 | PT-886; PT886 | Phase 2 Clinical | Phanes Therapeutics Inc | Solid tumours; Esophageal Neoplasms; Stomach Neoplasms; Pancreatic Neoplasms; Carcinoma, Pancreatic Ductal | Details |
IMM-2902 | IMM-2902 | Phase 2 Clinical | ImmuneOnco Biopharmaceuticals (Shanghai) Co Ltd | Solid tumours; Stomach Neoplasms; Breast Neoplasms; Cholangiocarcinoma; Lung Neoplasms | Details |
6MW-3211 | 6MW3211; 6MW-3211 | Phase 2 Clinical | Mabwell (Shanghai) Bioscience Co Ltd | Carcinoma, Renal Cell; Myelodysplastic Syndromes; Neoplasms; Leukemia, Myeloid, Acute; Lung Neoplasms; Lymphoma | Details |
HX-009 | HX-009 | Phase 2 Clinical | Hanx Biopharmaceutical Co Ltd, Wuhan Hanxiong Biotechnology Co Ltd | Solid tumours; Liver Neoplasms; Stomach Neoplasms; Lymphoma | Details |
CC-90002 | INBRX-103; CC-90002 | Phase 1 Clinical | Inhibrx | Hematologic Neoplasms; Myelodysplastic Syndromes; Leukemia, Myeloid, Acute | Details |
Anti-CD47 monoclonal antibody (Biocad) | Phase 1 Clinical | Biocad | Neoplasms | Details | |
IMC-002(Immuneoncia) | IMC-002; 3D-197; 3D197 | Phase 1 Clinical | Immuneoncia Therapeutics Inc | Solid tumours; Hematologic Neoplasms; Neoplasms; Lymphoma; Neoplasm Metastasis | Details |
Recombinant humanized monoclonal antibody MIL95 (Mabworks/Connaught Biomedical Technology) | MIL-95; CM-312 | Phase 1 Clinical | Beijing Mabworks Biotech Co Ltd | Solid tumours; Neoplasms; Leukemia, Myeloid, Acute; Lymphoma | Details |
Zeripatamig | NI-1701; TG-1801 | Phase 1 Clinical | Novimmune Sa | Lymphoma, B-Cell | Details |
SL-172154 | SL-172154 | Phase 1 Clinical | Shattuck Labs Inc | Ovarian Neoplasms; Squamous Cell Carcinoma of Head and Neck; Carcinoma, Ovarian Epithelial; Myelodysplastic Syndromes; Peritoneal Neoplasms; Fallopian Tube Neoplasms; Carcinoma, Squamous Cell; Leukemia, Myeloid, Acute | Details |
Urabrelimab | SRF-231 | Phase 1 Clinical | Surface Oncology Inc | Hematologic Neoplasms; Solid tumours | Details |
Simridarlimab | IBI-322; IBI322 | Phase 1 Clinical | Innovent Biologics(Suzhou) Co Ltd | Hematologic Neoplasms; Solid tumours; Bone Marrow Neoplasms; Neoplasms; Leukemia, Myeloid, Acute; Lymphoma; Lymphoma, T-Cell | Details |
ZL-1201 | ZL-1201 | Phase 1 Clinical | Zai Lab (Shanghai) Co Ltd | Hematologic Neoplasms; Solid tumours; Neoplasms | Details |
AUR-103 | AUR-103 | Phase 1 Clinical | Aurigene | Leukemia; Solid tumours; Myelodysplastic Syndromes; Lymphoma, Non-Hodgkin; Leukemia, Myeloid, Acute | Details |
HMPL-A83 | HMPL-A-83; HMPL-A83 | Phase 1 Clinical | Hutchison Medipharma Ltd | Solid tumours; Hematologic Neoplasms; Neoplasms | Details |
NI-1801 | NI-1801 | Phase 1 Clinical | Light Chain Bioscience Ltd | Solid tumours; Triple Negative Breast Neoplasms; Carcinoma, Ovarian Epithelial; Carcinoma, Non-Small-Cell Lung | Details |
AK-132 | AK132; AK-132 | Phase 1 Clinical | Zhongshan Akeso Biopharma Co Ltd | Solid tumours; Neoplasms | Details |
HCB-101 | HCB-101 | Phase 1 Clinical | HanchorBio Inc | Solid tumours; Lymphoma, Non-Hodgkin | Details |
D3L-001 | D3L-001 | Phase 1 Clinical | D3 Bio (Wuxi) Co Ltd | Solid tumours; Neoplasms | Details |
FP-002 (Fapon Biopharma) | FP-002 | Phase 1 Clinical | Fapon Biotech Inc | Solid tumours; Neoplasms | Details |
AUR-105 | AUR-105 | Phase 1 Clinical | Aurigene | Solid tumours; Hodgkin Disease; Lymphoma, Non-Hodgkin | Details |
BC-007 (Dragonboat Biopharmaceutical) | BC-007 | Phase 1 Clinical | Dragonboat Biopharmaceutical | Solid tumours; Neoplasms | Details |
BSI-082 | BSI-082 | Phase 1 Clinical | Boaoxin Biotechnology(Nanjing) Co Ltd | Hematologic Neoplasms; Solid tumours | Details |
SG-1906 | SG-1906; SG1906 | Phase 1 Clinical | Hangzhou Sumgen Biotechnology Co Ltd | Solid tumours; Neoplasms | Details |
SG-2501 | SG-2501 | Phase 1 Clinical | Hangzhou Sumgen Biotechnology Co Ltd | Hematologic Neoplasms; Lymphoma | Details |
PT-217 | PT-217 | Phase 1 Clinical | Phanes Therapeutics Inc | Solid tumours; Small Cell Lung Carcinoma; Pancreatic neuroendocrine tumors (pNET); Prostatic Neoplasms; Carcinoma, Neuroendocrine | Details |
LD-002 | LD-002 | Phase 1 Clinical | Zhejiang Blue Shield Pharmaceutical Co Ltd | Hematologic Neoplasms; Solid tumours; Lymphoma, Non-Hodgkin | Details |
SHS-009 | SHS-009; SH009; SH-009 | Phase 1 Clinical | Nanjing Sanhome Pharmaceutical Co Ltd | Neoplasms | Details |
Monoclonal Antibody (Mab) sB24M | Phase 1 Clinical | Swiss Biopharma Med GmbH | Pyoderma Gangrenosum; Pyoderma | Details | |
IMM-2520 | IMM-2520 | Phase 1 Clinical | ImmuneOnco Biopharmaceuticals (Shanghai) Co Ltd | Solid tumours; Squamous Cell Carcinoma of Head and Neck; Small Cell Lung Carcinoma; Breast Neoplasms; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung | Details |
BAT-7104 | BAT-7104 | Phase 1 Clinical | Bio-Thera Solutions Ltd | Solid tumours; Neoplasms | Details |
STI-6643 | STI-6643 | Phase 1 Clinical | Sorrento Therapeutics Inc | Solid tumours; Neoplasms | Details |
PF-07257876 | Phase 1 Clinical | Pfizer Inc | Ovarian Neoplasms; Squamous Cell Carcinoma of Head and Neck; Carcinoma, Non-Small-Cell Lung | Details | |
TQB-2928 | TQB-2928 | Phase 1 Clinical | Jiangsu Chia Tai-Tianqing Pharmaceutical Co Ltd | Hematologic Neoplasms; Solid tumours; Myelodysplastic Syndromes; Neoplasms; Leukemia, Myeloid, Acute | Details |
JMT-601 | JMT-601 | Phase 1 Clinical | Shanghai Jmt-Bio Inc | Lymphoma, B-Cell; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin | Details |
IMM2505 | IMM2505; IMM-2505 | Phase 1 Clinical | SunHo (China) BioPharmaceutical Co Ltd, ImmuneOnco Biopharmaceuticals (Shanghai) Co Ltd | Solid tumours | Details |
SG12473 | SG12473; SG-12473 | Phase 1 Clinical | Hangzhou Sumgen Biotechnology Co Ltd | Hematologic Neoplasms; Solid tumours; Neoplasms | Details |
SG404 | SG-404; SG404 | Phase 1 Clinical | Hangzhou Sumgen Biotechnology Co Ltd | Neoplasms | Details |
Kintuzumab(GenSci) | Phase 1 Clinical | Changchun GeneScience Pharmaceuticals Co Ltd | Solid tumours; Hematologic Neoplasms; Myelodysplastic Syndromes; Lymphoma, Non-Hodgkin; Leukemia, Myeloid, Acute; Lymphoma | Details | |
Letaplimab | IBI-188 | Phase 1 Clinical | Innovent Biologics(Suzhou) Co Ltd | Solid tumours; Adenocarcinoma of Lung; Neoplasms; Myelodysplastic Syndromes; Osteosarcoma; Leukemia, Myeloid, Acute | Details |
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