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Your Position: Casa > Protein > ROR1 > RO1-M5250

Mouse ROR1 Protein, Fc Tag (MALS verified)

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  • Sinónimo
    ROR1,NTRKR1
  • Fuente
    Mouse ROR1, Fc Tag (RO1-M5250) is expressed from human 293 cells (HEK293). It contains AA Gln 30 - Glu 403 (Accession # Q9Z139).
    Predicted N-terminus: Gln 30
  • Caracterización molecular
    Online(Gln 30 - Glu 403) Q9Z139

    This protein carries a human IgG1 Fc tag at the C-terminus.

    The protein has a calculated MW of 68.4 kDa. The protein migrates as 76-96 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxina
    Less than 1.0 EU per μg by the LAL method.
  • Pureza

    >95% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulación

    Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • Reconstitución

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Almacenamiento

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Mouse ROR1, Fc Tag (Cat. No. RO1-M5250) SDS-PAGE gel

Mouse ROR1, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

SEC-MALS
Mouse ROR1, Fc Tag (Cat. No. ) MALS images

The purity of Mouse ROR1, Fc Tag (Cat. No. RO1-M5250) is more than 90% and the molecular weight of this protein is around 150-180 kDa verified by SEC-MALS.

  • Antecedentes
    Tyrosine-protein kinase transmembrane receptor ROR1 is also known as Neurotrophic tyrosine kinase, receptor-related 1 (NTRKR1), which belongs to the protein kinase superfamily or tyr protein kinase family or ROR subfamily. ROR1 contains 1 FZ (frizzled) domain, 1 Ig-like C2-type (immunoglobulin-like) domain, 1 kringle domain, 1 protein kinase domain. ROR1 is expressed at high levels during early embryonic development. The expression levels drop strongly around day 16 and there are only very low levels in adult tissues. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm. ROR1 could interact with casein kinase 1 epsilon (CK1ε) to activate phosphoinositide 3-kinase-mediated AKT phosphorylation and cAMP-response-element-binding protein (CREB), which was associated with enhanced tumor-cell growth.
  • Clinical and Translational Updates
      
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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Price(EUR) : €350.00

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