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HGF

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Cat. No. Especies Descripción del producto Estructura Pureza Característica
HGF-H5218 Human Human HGF Protein, premium grade
HGF-H5218-structure
HGF-H5218-sds
CRS-B012 Human ClinMax™ Human HGF ELISA Kit
HGF-H5253 Human Human HGF Protein, Fc Tag (MALS verified)
HGF-H5253-structure
HGF-H5253-sds
HGF-H52H3 Human Human HGF Protein, His Tag (MALS verified)
HGF-H52H3-structure
HGF-H52H3-sds
ACRO Quality

Part of Bioactivity data

HGF-H5218-Cell-based assay
HGF CELL

Human HGF Protein, premium grade (Cat. No. HGF-H5218) stimulates the secrection IL-11 by Saos-2 cells. The specific activity of Human HGF Protein, premium grade is > 6.00 x 10^5 IU/mg, which is calibrated against WHO Hepatocyte Growth Factor(NIBSC code: 96/556) (QC tested).

Protocol
HGF-H52H3-Cell-based assay
HGF CELL

Human HGF Protein, His Tag (Cat. No. HGF-H52H3) stimulates the secrection IL-11 by Saos-2 cells. The specific activity of Human HGF Protein, His Tag is >6.00 x 10^5 IU/mg, which is calibrated against WHO Hepatocyte Growth Factor (precursor) (Human rDNA derived) (NIBSC code: 96/556) (QC tested).

Protocol
HGF-H52H3-SPR
HGF SPR

Human HGF R, Fc Tag (Cat. No. MET-H5256) captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind Human HGF Protein, His Tag (Cat. No. HGF-H52H3) with an affinity constant of 0.486 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Protocol
HGF-H52H3-BLI
HGF BLI

Loaded Human HGF R, Fc Tag (Cat. No. MET-H5256) on Protein A Biosensor, can bind Human HGF Protein, His Tag (Cat. No. HGF-H52H3) with an affinity constant of 3.29 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Protocol

Synonym Name

HGF,HPTA,SF

Background

Hepatocyte growth factor (HGF)  is a paracrine cellular growth, motility and morphogenic factor. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. In addition, HGF has been implicated in a variety of cancers, including of the lungs, pancreas, thyroid, colon, and breast.

Clinical and Translational Updates

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