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Explore our series of high-quality proteins covering comprehensive diagnostic indicators in order to facilitate the in vitro diagnostic research of neurological diseases.
Pre-formed fibrils are an invaluable preclinical model for exploring pathogenesis of neurological diseases through aggregation of misfolded proteins. Explore our pre-seeded PFFs to use in your research.
Neural factors are a class of protein molecules with neurotrophic activity that can promote the survival and regeneration of nerve cells. Explore our series of recombinant neural factors to support the culture and differentiation of nerve cells.
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Neural antibodies can specifically label and recognize molecules on nerve cells, enabling a more comprehensive understanding and study of the biological properties, functions, and mechanisms of nerve cells in neurodegenerative diseases.
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Los marcadores de proteínas son un componente esencial en la investigación biológica y el desarrollo de fármacos. Ya sea para electroforesis de proteínas o western blot (Mancha Occidental), nuestros marcadores de proteínas teñidos previamente le ayudan a determinar rápidamente el peso molecular de la proteína objetivo o a evaluar la eficacia de la transferencia.
La estreptavidina es una proteína tetramérica que proporciona 4 sitios de unión de biotina de alta afinidad. Ofrecemos una amplia gama de productos preconjugados con estreptavidina para apoyar su investigación, así como proteínas biotiniladas.
El ajuste del anticuerpo de control de isotipo correspondiente para detectar la unión no específica puede reducir la generación de resultados falsos positivos y evaluar los posibles factores de influencia con precisión en el proceso de desarrollo de fármacos. Explore nuestros controles de isotipo para su investigación.
La eficacia de un anticuerpo terapéutico depende del fragmento Fab y de su actividad de unión al antígeno objetivo, pero también depende del fragmento Fc y de su interacción con receptores Fc clave, por lo que los candidatos deben probarse frente a un panel de receptores durante la ingeniería de anticuerpos. ¡Explore nuestra amplia colección de proteínas recombinantes del receptor Fc!
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Synonym Name
RP1-261G23.1,MGC70609,MVCD1,VEGFA,VPF
Background
Vascular endothelial growth factor (VEGF), also known as vascular permeability factor (VPF) and VEGF-A, and is a member of the platelet-derived growth factor (PDGF)/vascular endothelial growth factor (VEGF) family and encodes a protein that is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Alternatively spliced transcript variants, encoding either freely secreted or cell-associated isoforms, have been characterized. Alternatively spliced isoforms of 121,145,165,183,189 and 206 amino acids in length are expressed in humans. Mature human VEGF189 shares 88% aa sequence identity with mouse VEGF188. VEGF189 binds to heparan sulfate both on the cell surface and in the extracellular matrix (ECM) where it retains bioactivit. Furthermore, VEGF189 interacts with various receptors including VEGF R1, VEGF R2, Neuropilin-1, and Integrins aVb3, aVb5, a3b1, and a5b1.
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