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Brief Information

Name:T-cell-specific surface glycoprotein CD28
Target Synonym:CD28,CD28 Antigen,T-Cell-Specific Surface Glycoprotein CD28,CD28 Antigen (Tp44),Tp44,CD28 Antigens,CD28 Molecule,T-Cell-Specific Surface Glycoprotein
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:25
Lastest Research Phase:Phase 3 Clinical

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Cat. No. Especies Descripción del producto Estructura Pureza Característica
CD8-H52H3 Human / Cynomolgus / Rhesus macaque Human / Cynomolgus / Rhesus macaque CD28 Protein, His Tag, active dimer (MALS verified)
EP-151 Human CD28 : B7-2 [Biotinylated] Inhibitor Screening ELISA Kit
EP-150 Human CD28 : B7-1 [Biotinylated] Inhibitor Screening ELISA Kit
CRS-A014 Mouse resDetect™ Anti-CD28 Antibody ELISA Kit
CD8-R52H9 Rat Rat CD28 Protein, His Tag (BLI verified)
CD8-M5258 Mouse Mouse CD28 Protein, Fc Tag (MALS verified)
CD8-M82E3 Mouse Biotinylated Mouse CD28 Protein, His,Avitag™, active dimer (MALS verified)
CD8-H82E5 Human / Cynomolgus / Rhesus macaque Biotinylated Human / Cynomolgus / Rhesus macaque CD28 Protein, His,Avitag™, active dimer (MALS verified)
CD8-H525a Human / Cynomolgus / Rhesus macaque Human / Cynomolgus / Rhesus macaque CD28 Protein, Fc Tag, active dimer (MALS verified)
CD8-H52A5 Human / Cynomolgus / Rhesus macaque Human / Cynomolgus / Rhesus macaque CD28 Protein, Mouse IgG2a Fc Tag (MALS verified)
CD8-H82F2 Human / Cynomolgus / Rhesus macaque Biotinylated Human / Cynomolgus / Rhesus macaque CD28 Protein, Fc,Avitag™, active dimer (MALS verified)
CD8-M52H6 Mouse Mouse CD28 Protein, His Tag, active dimer (MALS verified)
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Synonym Name



T-cell-specific surface glycoprotein CD28 is also known as TP44, is a single-pass type I membrane protein which contains one Ig-like V-type (immunoglobulin-like) domain. is one of the molecules expressed on T cells that provide co-stimulatory signals, which are required for T cell activation. CD28 is the receptor for CD80 (B7.1) and CD86 (B7.2). When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen presenting cells (APCs). The CD86 expression on antigen presenting cells is constitutive. CD28 is the only B7 receptor constitutively expressed on naive T cells.

Clinical and Translational Updates

Related Molecule

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Reltecimod P2-TA; AB-103 Phase 3 Clinical Atox Bio Ltd Peritonitis; Acute Kidney Injury; Fasciitis, Necrotizing; Fournier Gangrene; Soft Tissue Infections Details
Nezastomig REGN-5678 Phase 2 Clinical Regeneron Pharmaceuticals Inc Carcinoma, Renal Cell; Prostatic Neoplasms, Castration-Resistant; Prostatic Neoplasms Details
Abatacept (Orban Biotech) Phase 2 Clinical Orban Biotech, The National Institute Of Diabetes And Digestive And Kidney Diseases Diabetes Mellitus, Type 1 Details
Lulizumab pegol Lulizumab; BMS-931699 Phase 2 Clinical Bristol-Myers Squibb Company Lupus Vulgaris; Rejection of renal transplantation; Sjogren-Larsson Syndrome Details
Acazicolcept ALPN-101 Phase 2 Clinical Alpine Immune Sciences Inc Graft vs Host Disease; Autoimmune Diseases; Lupus Erythematosus, Systemic; Lymphoproliferative Disorders; Inflammation Details
FR-104 FR-104; JNJ-3133; VEL-101 Phase 2 Clinical Effimune Rejection of renal transplantation; Arthritis, Rheumatoid; Postoperative Complications Details
TC-510 TC-510 Phase 2 Clinical Tcr2 Therapeutics Inc Ovarian Neoplasms; Solid tumours; Pancreatic Neoplasms; Triple Negative Breast Neoplasms; Mesothelioma; Cholangiocarcinoma; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung; Adenocarcinoma Details
REGN-7075 REGN-7075 Phase 2 Clinical Regeneron Pharmaceuticals Inc Solid tumours Details
REGN-5668 REGN-5668 Phase 2 Clinical Regeneron Pharmaceuticals Inc Ovarian Neoplasms; Peritoneal Neoplasms; Endometrial Neoplasms; Fallopian Tube Neoplasms Details
ATLCAR.k.CD28 cells (UNC Lineberger Comprehensive Cancer Center) Phase 1 Clinical Unc Lineberger Comprehensive Cancer Center Lymphoma, B-Cell, Marginal Zone; Lymphoma, Follicular; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Lymphoma Details
SAR-442257 SAR-442257 Phase 1 Clinical Sanofi Neoplasms Details
Autologous CD19CAR-CD28-CD3zeta-EGFRt-expressing Tcm-enriched T cells (City of Hope Medical Center) Phase 1 Clinical City Of Hope National Medical Center Lymphoma, Non-Hodgkin Details
JNJ-1493 JNJ-1493 Phase 1 Clinical Xencor Inc Hematologic Neoplasms; Lymphoma, B-Cell Details
JNJ-9401 JNJ-9401 Phase 1 Clinical Xencor Inc Prostatic Neoplasms Details
JNJ-87189401 JNJ-87189401 Phase 1 Clinical Janssen Research & Development Llc Prostatic Neoplasms Details
REGN5837 REGN5837; REGN-5837 Phase 1 Clinical Regeneron Pharmaceuticals Inc Lymphoma, B-Cell; Lymphoma, Non-Hodgkin Details
CC-312 CC-312 Phase 1 Clinical CytoCares (Shanghai) Inc Hematologic Neoplasms; Lymphoma, B-Cell; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Lymphoma, Non-Hodgkin; Leukemia, Lymphocytic, Chronic, B-Cell Details
RG-6333 RO-7443904 Phase 1 Clinical F. Hoffmann-La Roche Ag Lymphoma, Non-Hodgkin Details
XmAb-808 XmAb808 Phase 1 Clinical Xencor Inc Carcinoma, Renal Cell; Squamous Cell Carcinoma of Head and Neck; Carcinoma, Transitional Cell; Carcinoma, Ovarian Epithelial; Triple Negative Breast Neoplasms; Prostatic Neoplasms, Castration-Resistant; Colorectal Neoplasms; Melanoma; Carcinoma, Non-Small-Cell Lung Details
SAR-443216 SAR-443216 Phase 1 Clinical Sanofi Solid tumours; Stomach Neoplasms; Neoplasms; Breast Neoplasms; Lung Neoplasms Details
CD19 PD-1/CD28 CAR-T Cell Therapy (Second Affiliated Hospital School Of Zhejiang University School Of Medicine) Phase 1 Clinical Second Affiliated Hospital Of Zhejiang University School Of Medicine Lymphoma, B-Cell; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Mantle-Cell; Lymphoma, Follicular; Primary mediastinal B cell lymphoma Details
FPT-155 CD80-Fc; FPT-155 Phase 1 Clinical Five Prime Therapeutics Inc Solid tumours Details
Theralizumab TAB-08; TABO-8 Phase 1 Clinical Theramab Llc Solid tumours; Carcinoma, Merkel Cell; Arthritis, Rheumatoid; Psoriasis; Lupus Erythematosus, Systemic Details
B7-2/GM-CSF cancer gene therapy CIT Phase 1 Clinical Radient Neoplasms Details
InHeAb-01 InHeAb-01; bsAB Clinical University Hospital Tuebingen Neoplasms Details

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