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Your Position: Casa > Fc gamma RIIIA / CD16a

Fc gamma RIIIA / CD16a

Brief Information

Name:Low affinity immunoglobulin gamma Fc region receptor III-A
Target Synonym:IGFR3,FCG3,Fc Fragment Of IgG, Low Affinity IIIa, Receptor For (CD16),Fc Fragment Of IgG, Low Affinity III, Receptor For (CD16),Immunoglobulin G Fc Receptor III,Fc-Gamma Receptor III-2 (CD 16),Neutrophil-Specific Antigen NA,Fc-Gamma Receptor IIIb (CD16),Fc Gamma Receptor III-A,Low Affinity Immunoglobulin Gamma Receptor III-A Fc Fragment,IgG Fc receptor III-2,Low affinity immunoglobulin gamma Fc region receptor III-A,FCGR3,CD16A,Fc-gamma RIII-alpha,FCGR3A,Fc Fragment Of IgG Receptor IIIa,Fc Fragm
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:14
Lastest Research Phase:Phase 2 Clinical

Antibody Licensing

Project Name Project Stage Molecule Type Host Species Therapeutic Area Indications
CD16a VHH - 01 PCC Solid Tumor Solid tumor,Hematoma

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Cat. No. Especies Descripción del producto Estructura Pureza Característica
FRT-06 Human Human Fc gamma RIIIA / CD16a (F176) binding Kit (TR-FRET)
FRT-07 Human Human Fc gamma RIIIA / CD16a (V176) binding Kit (TR-FRET)
SCCHO-ATP059H Human CHO/Human CD16a (158V) Stable Cell Line (High Expression) Development Service
SCCHO-ATP059L Human CHO/Human CD16a (158V) Stable Cell Line (Low Expression) Development Service
SCCHO-ATP059M Human CHO/Human CD16a (158V) Stable Cell Line (Medium Expression) Development Service
CDA-H52H6 Human Human Fc gamma RIIIA / CD16a (F176, S197P) Protein, His Tag (MALS&SPR verified)
CDA-H52H6-structure
CDA-H52H6-sds
CDA-H52S1 Human Human Fc gamma RIIIA / CD16a (V176) Protein, HSA,His Tag (MALS & BLI verified)
CDA-H52S1-structure
CDA-H52S1-sds
CDA-H5290 Human Human Fc gamma RIIIA / CD16a (V176) Protein, SUMO,His Tag (MALS & BLI verified)
CDA-H5290-structure
CDA-H5290-sds
CDA-H82E9 Human Biotinylated Human Fc gamma RIIIA / CD16a (V176) Protein, Avitag™,His Tag (HPLC & SPR & BLI verified)
CDA-H82E9-structure
CDA-H82E9-sds
CDA-H82E9-hplc
CDA-H82E8 Human Biotinylated Human Fc gamma RIIIA / CD16a (F176) Protein, Avitag™,His Tag (SPR & BLI & MALS verified)
CDA-H82E8-structure
CDA-H82E8-sds
CD8-H52H4 Human Human Fc gamma RIIIA / CD16a (V176) Protein, His Tag (SPR & BLI & MALS verified)
CD8-H52H4-structure
CD8-H52H4-sds
CDA-H5220 Human Human Fc gamma RIIIA / CD16a (F176) Protein, His Tag (MALS & SPR verified)
CDA-H5220-structure
CDA-H5220-sds
ACRO Quality

Part of Bioactivity data

SCCHO-ATP059H-Cell-based assay
 Fc gamma RIIIA / CD16a FACS

Expression analysis of human CD16a on CHO/Human CD16a (158V) Stable Cell Line by FACS.
Cell surface staining using PE-labeled anti-human CD16a antibody was performed on CHO/Human CD16a (158V) Stable Cell Line with different expression levels: CHO/Human CD16a (158V) Stable Cell Line (Low Expression); CHO/Human CD16a (158V) Stable Cell Line (Medium Expression); CHO/Human CD16a (158V) Stable Cell Line (High Expression).

SCCHO-ATP059L-Cell-based assay
 Fc gamma RIIIA / CD16a FACS

Expression analysis of human CD16a on CHO/Human CD16a (158V) Stable Cell Line by FACS.
Cell surface staining using PE-labeled anti-human CD16a antibody was performed on CHO/Human CD16a (158V) Stable Cell Line with different expression levels: CHO/Human CD16a (158V) Stable Cell Line (Low Expression); CHO/Human CD16a (158V) Stable Cell Line (Medium Expression); CHO/Human CD16a (158V) Stable Cell Line (High Expression).

CDA-H52H6-SPR
 Fc gamma RIIIA / CD16a SPR

Human CD16a (F176, S197P) Protein, His Tag (Cat. No. CDA-H52H6) captured on CM5 chip via anti-His antibody can bind Rituximab with an affinity constant of 0.414 μM as determined in a SPR assay (Biacore 8K) (QC tested).

CDA-H82E9-SPR
 Fc gamma RIIIA / CD16a SPR

Biotinylated Human CD16a (V176), Avitag,His Tag (SPR & BLI verified) (Cat. No. CDA-H82E9) captured on Biotin CAP- Series S Sensor Chip can bind Rituximab biosimilar (Cat. No. CD0-M36) with an affinity constant of 0.367μM as determined in a SPR assay (Biacore 8K) (QC tested).

Customer Reviews

Synonym Name

FCGR3A,CD16A,FCG3,FCGR3,IGFR3

Background

CD16 is a low affinity Fc receptor, and has been identified as Fc receptors FcγRIIIa (CD16a) and FcγRIIIb (CD16b). These receptors bind to the Fc portion of IgG antibodies. CD16 encoded by two different highly homologous genes in a cell type-specific manner.CD16 is found on the surface of natural killer cells, neutrophil polymorphonuclear leukocytes, monocytes and macrophages.CD16a antigen is also known as Low affinity immunoglobulin gamma Fc region receptor III-A, Fc-gamma RIII-alpha. CD16b is a low-affinity, GPI-linked receptor expressed by neutrophils and eosinophils, whereas CD16a is an intermediate affinity polypeptide-anchored transmembrane glycoprotein expressed  natural killer cells, macrophages, subpopulation of T-cells, immature thymocytes and placentaltrophoblasts.CD16a is involved in phagocytosis, secretion of enzymes and inflammatory mediators, antibody­dependent cytotoxicity and clearance of immune complexes. Aberrant expression or mutations of CD16a is implicated in susceptibility to recurrent viral infections, systemic lupus erythematosus, and alloimmune neonatal neutropenia.

Clinical and Translational Updates

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