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NKp30

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Cat. No. Especies Descripción del producto Estructura Pureza Característica
NC3-H5256 Human Human NKp30 / NCR3 / CD337 Protein, Llama IgG2b Fc Tag, low endotoxin
NC3-H5256-structure
NC3-H5256-sds
NC3-H5259 Human Human NKp30 / NCR3 / CD337 Protein, Fc Tag
NC3-H5259-structure
NC3-H5259-sds
NC3-H5228 Human Human NKp30 / NCR3 / CD337 Protein, His Tag
NC3-H5228-structure
NC3-H5228-sds
ACRO Quality

Part of Bioactivity data

NC3-H5228-SPR
NKp30 SPR

Biotinylated Human B7-H6, His,Avitag (Cat. No. B76-H82E5) immobilized on SA Chip can bind Human NKp30, His Tag (Cat. No. NC3-H5228) with an affinity constant of 0.213 μM as determined in a SPR assay (Biacore T200) (Routinely tested).

Protocol
NC3-H5259-ELISA
NKp30 ELISA

Immobilized Human B7-H6, His Tag (Cat. No. B76-H52H8) at 10 μg/mL (100 μL/well) can bind Human NKp30, Fc Tag (Cat. No. NC3-H5259) with a linear range of 2-78 ng/mL (QC tested).

Protocol

Synonym Name

NCR3,CD337,NKp30,1C7,LY117,MALS

Background

Natural cytotoxicity triggering receptor 3 (NCR3) is also known as Activating natural killer receptor p30, Natural killer cell p30-related protein (NK-p30), CD antigen CD337, 1C7, LY117. NCR3 /CD337 /NKp30 belongs to the natural cytotoxicity receptor (NCR) family. NCR3 /NKp30 contains one Ig-like (immunoglobulin-like) domain. NCR3 /NKp30 is selectively expressed by all resting and activated NK cells and weakly expressed in spleen. NCR3 is homodimer in the unliganted form. NCR3 interacts with CD3Z. NCR3 interacts with and is activated by binding to NCR3LG1 or BAG6. Engagement of NCR3 by BAG6 also promotes dendritic cell (DC) maturation, both through killing those DCs that did not properly acquire a mature phenotype, and inducing NK cells to release TNFA and IFNG, which promotes DC maturation.

Clinical and Translational Updates

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