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Your Position: Casa > Her2

Her2

Brief Information

Name:Receptor protein-tyrosine kinase erbB-2
Target Synonym:EC 2.7.10.1,HER-2/Neu,Herstatin,HER-2,TKR1,Receptor, ErbB-2,V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/Glioblastoma Derived Oncogene Homolog,V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncoprotein 2,Neuroblastoma/Glioblastoma Derived Oncogene Homolog,C-Erb B2/Neu Protein,CD340 Antigen,EC:2.7.10.1,EC 2.7.10,MLN 19,CD340,Tyrosine kinase-type cell surface receptor HER2,Receptor tyrosine-protein kinase erbB-2,ERBB2,MLN19,Proto-oncogene Neu,Erb-B2 Receptor Tyrosine Kinase 2,V-E
Number of Launched Drugs:39
Number of Drugs in Clinical Trials:201
Lastest Research Phase:Approved

Licensing

Project Name Modality Therapeutic Area Indications Stage Right Available
Anti-Her2 II / Anti-Her2 IV Bi-specific antibody ADC Bioconjugates Oncology/Cancer Solid tumor Preclinical Global
Her2xCD3 BsAb Bispecific antibody Oncology/Cancer HER2-positive Cancer Phase I Global

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Cat. No. Especies Descripción del producto Estructura Pureza Característica
HE2-M598 Human Monoclonal Anti-Her2 Antibody, Human IgG1
HE2-M598-sds
HE2-M82F3 Mouse Biotinylated Mouse Her2 / ErbB2 Protein, Fc,Avitag™ (MALS verified)
HE2-M82F3-structure
HE2-M82F3-sds
CHEK-ATP150 Human HEK293/Human ErbB2 Stable Cell Line
HE2-M82E3 Mouse Biotinylated Mouse Her2 / ErbB2 Protein, His,Avitag™ (MALS verified)
HE2-M82E3-structure
HE2-M82E3-sds
HE2-M5253 Mouse Mouse Her2 / ErbB2 Protein, Fc Tag (MALS verified)
HE2-M5253-structure
HE2-M5253-sds
HE2-C5253 Cynomolgus Cynomolgus Her2 / ErbB2 Protein, Fc Tag
HE2-C5253-structure
HE2-C5253-sds
HE2-C82F3 Cynomolgus Biotinylated Cynomolgus Her2 / ErbB2 Protein, Fc,Avitag™
HE2-C82F3-structure
HE2-C82F3-sds
CAA-B004 Rabbit Recombinant Monoclonal Anti-HER2 Antibody, Rabbit (5D5), Ready-To-Use
MBS-C006 Human ActiveMax® Human Her2 μBeads, premium grade (for cells)
HGS-S254 Rabbit Recombinant Monoclonal Anti-HER2 Antibody, Rabbit (5D5)
HE2-HA2H9 Human APC-Labeled Human Her2 / ErbB2 Protein, His TagStar Staining
HE2-HP2H8 Human PE-Labeled Human Her2 / ErbB2 Protein, His TagStar Staining
HE2-HA2H3 Human Alexa Fluor™ 488-Labeled Human Her2 / ErbB2 Protein, His TagStar Staining
HE2-HA2H4 Human Alexa Fluor™ 555-Labeled Human Her2 / ErbB2 Protein, His TagStar Staining
HE2-HA2H5 Human Alexa Fluor™ 647-Labeled Human Her2 / ErbB2 Protein, His TagStar Staining
HE2-HA2H7 Human APC-Labeled Human Her2 / ErbB2 Protein, His Tag (Site-specific conjugation)
HE2-HA2H7-structure
HE2-R52H8 Rabbit Rabbit Her2 / ErbB2 Protein, His Tag (MALS verified)
HE2-R52H8-structure
HE2-R52H8-sds
HE2-HF256 Human FITC-Labeled Human Her2 / ErbB2 Protein, Fc Tag
HE2-HF256-structure
HE2-HF256-sds
HE2-HP2E3 Human PE-Labeled Human Her2 / ErbB2 Protein, His Tag (Site-specific conjugation)
HE2-HP2E3-structure
HE2-H52H9 Human Human Her2 / ErbB2 (23-510) Protein, His Tag (MALS verified)
HE2-H52H9-structure
HE2-H52H9-sds
HE2-H52H3 Human Human Her2 / ErbB2 (S310Y) Protein, His Tag (MALS verified)
HE2-H52H3-structure
HE2-H52H3-sds
HE2-H52H2 Human Human Her2 / ErbB2 (S310F) Protein, His Tag
HE2-H52H2-structure
HE2-H52H2-sds
MBS-K006 Human Human HER2-coupled Magnetic Beads
HE2-H52H4 Human Human Her2 / ErbB2 (498-648) Protein, His Tag
HE2-H52H4-structure
HE2-H52H4-sds
HE2-HF224 Human FITC-Labeled Human Her2 / ErbB2 Protein, His Tag
HE2-HF224-structure
HE2-HF224-sds
HE2-H5255 Human Human Her2 / ErbB2 Protein, Mouse IgG2a Fc Tag (MALS verified)
HE2-H5255-structure
HE2-H5255-sds
HE2-C82E3 Cynomolgus Biotinylated Cynomolgus Her2 / ErbB2 Protein, His,Avitag™ (MALS verified)
HE2-C82E3-structure
HE2-C82E3-sds
HE2-H5212 Human Human Her2 / ErbB2 Protein, Tag Free (MALS verified)
HE2-H5212-structure
HE2-H5212-sds
HE2-C52Hb Cynomolgus Cynomolgus Her2 / ErbB2 Protein, His Tag (MALS verified)
HE2-C52Hb-structure
HE2-C52Hb-sds
EHM-V1 Mouse ELISA Assay Kit for Anti-HER-2 h-mAb in Mouse Serum
HE2-H82E2 Human Biotinylated Human Her2 / ErbB2 Protein, His,Avitag™, premium grade
HE2-H82E2-structure
HE2-H82E2-sds
HE2-H822R Human Biotinylated Human Her2 / ErbB2 Protein, His Tag, ultra sensitivity (primary amine labeling, long spacer) (MALS verified)
HE2-H822R-structure
HE2-H822R-sds
HE2-H5287 Human Human Her2 / ErbB2 Protein, Twin-Strep Tag (MALS verified)
HE2-H5287-structure
HE2-H5287-sds
ER2-M5220 Mouse Mouse Her2 / ErbB2 Protein, His Tag (MALS verified)
ER2-M5220-structure
ER2-M5220-sds
HE2-H5253 Human Human Her2 / ErbB2 Protein, Fc Tag, premium grade
HE2-H5253-structure
HE2-H5253-sds
HE2-H5225 Human Human Her2 / ErbB2 Protein, His Tag (MALS verified)
HE2-H5225-structure
HE2-H5225-sds
ACRO Quality

Part of Bioactivity data

CHEK-ATP150-Cell-based assay
Her2 FACS

Expression analysis of human ErbB2 on HEK293/Human ErbB2 Stable Cell Line by FACS.
Cell surface staining was performed on HEK293/Human ErbB2 Stable Cell Line or negative control cell using anti-human ErbB2 Antibody followed by staining with PE anti-human IgG Fc Antibody.

Protocol
MBS-C006-Cell-based assay
Her2 FACS

Assay of Human Her2 on the μBeads surface by Flow cytometry. ActiveMax® Human Her2 μBeads, premium grade (for cells) (Cat. No. MBS-C006) surface was fluorescently stained using Anti-Her2 antibody and PE-anti-Human IgG Fc, analyzed by flow cytometry (QC tested).

Protocol
HE2-H82E2-SPR
Her2 SPR

Trastuzumab Biosimilar captured on Protein A Chip can bind Biotinylated Human Her2, His,Avitag, premium grade (Cat. No. HE2-H82E2) with an affinity constant of 7.49 nM as determined in a SPR assay (Biacore 8K) (QC tested).

Protocol
HE2-H5225-SPR
Her2 SPR

Herceptin (Trastuzumab) captured on CM5 chip via anti-human IgG Fc antibodies surface, can bind Human Her2, His Tag (Cat. No. HE2-H5225) with an affinity constant of 1.07 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

Protocol

Customer Reviews

Synonym Name

ERBB2,CD340,HER-2/neu,HER2,MLN19,NEU,NGL,TKR1

Background

Human Epidermal growth factor Receptor 2 (HER2) is also called ERBB2, HER-2,HER-2 /neu, NEU, NGL,TKR1 and c-erb B2,and is a protein giving higher aggressiveness in breast cancers. It is a member of the ErbB protein family, more commonly known as the epidermal growth factor receptor family. HER2 is a cell membrane surface-bound receptor tyrosine kinase and is normally involved in the signal transduction pathways leading to cell growth and differentiation. HER2 is thought to be an orphan receptor, with none of the EGF family of ligands able to activate it. Approximately 30% of breast cancers have an amplification of the HER2 gene or overexpression of its protein product. Overexpression of this receptor in breast cancer is associated with increased disease recurrence and worse prognosis. HER2 appears to play roles in development, cancer, communication at the neuromuscular junction and regulation of cell growth and differentiation .

Clinical and Translational Updates

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