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Your Position: Casa > NF-κB

NF-κB

Brief Information

Name:Nuclear factor NF-kappa-B complex
Target Synonym:NF-kappa B
Number of Launched Drugs:11
Number of Drugs in Clinical Trials:37
Lastest Research Phase:Approved

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ACRO Quality

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Glucosamine Hydrochloride Approved Dona, Xicil, Dolenio, Dona 200-S, Viartril-S Mainland China Osteoarthritis Bright Future Pharmaceutical Laboratories Ltd 2004-03-17 Insulin Resistance; Chronic Periodontitis; Osteoarthritis; Obesity Details
Charcoal AST-120; MP-146 Approved Kureha Co Kremezin, Zysa, Kremezin Fine Granules Japan Kidney Failure, Chronic Mitsubishi Tanabe Pharma 1991-10-04 Inflammatory Bowel Diseases; Irritable Bowel Syndrome; Pouchitis; Hepatic Encephalopathy; Intestinal Fistula; Asthma; Gastroesophageal Reflux; Renal Insufficiency, Chronic; Kidney Failure, Chronic Details
Mepacrine hydrochloride CBL-0102; CBLC-102; Curaxin CBLC-102 Approved Bayer AG Atebrin, Maladin, Atabrine, Tenicridine Lupus Erythematosus, Systemic; Giardiasis; Leishmaniasis; Malaria Bayer AG 1932-01-01 Creutzfeldt-Jakob Syndrome; Carcinoma, Renal Cell; Malaria; Giardiasis; Lupus Erythematosus, Systemic; Prostatic Neoplasms; Leishmaniasis Details
Anapsos EQA-00 Approved Asac Pharmaceutical International Psoriacen Psoriasis; Dermatitis, Atopic Asac Pharmaceutical International 1972-01-01 Psoriasis; Dermatitis, Atopic Details
Acetylaconitine Approved Mainland China Pain Shaanxi Xingbang Pharmacevtical Co Ltd 1985-01-01 Pain Details
Andrographolide/Sodium Hydrogen Sulfite Approved Bacterial Infections Details
Glucosamine Hydrochloride/Chondroitin sulfate Approved Details
Glucosamine Hydrochloride/Indomethacin Approved Mainland China Spondylitis, Ankylosing; Spondylosis; Periarthritis; Arthritis, Rheumatoid; Arthritis null 1995-01-01 Spondylitis, Ankylosing; Arthritis, Rheumatoid; Periarthritis; Arthritis; Spondylosis Details
Glucosamine Hydrochloride/Dermatan sulfate Approved Details
Iguratimod T-614 Approved Jiangsu Simcere Pharmaceutical Co Ltd 艾得辛, Colvet, Iremod, Kolbet, Careram Mainland China Arthritis, Rheumatoid Hainan Simcere Pharmaceutical Co Ltd 2011-08-15 Graft vs Host Disease; Sjogren's Syndrome; Arthritis, Rheumatoid Details
Anvirzel Approved Nerium Biotechnology Inc, Ozelle Pharmaceuticals Inc Anvirzel Neoplasms Details
Glucosamine Hydrochloride Approved Dona, Xicil, Dolenio, Dona 200-S, Viartril-S Mainland China Osteoarthritis Bright Future Pharmaceutical Laboratories Ltd 2004-03-17 Insulin Resistance; Chronic Periodontitis; Osteoarthritis; Obesity Details
Charcoal AST-120; MP-146 Approved Kureha Co Kremezin, Zysa, Kremezin Fine Granules Japan Kidney Failure, Chronic Mitsubishi Tanabe Pharma 1991-10-04 Inflammatory Bowel Diseases; Irritable Bowel Syndrome; Pouchitis; Hepatic Encephalopathy; Intestinal Fistula; Asthma; Gastroesophageal Reflux; Renal Insufficiency, Chronic; Kidney Failure, Chronic Details
Mepacrine hydrochloride CBL-0102; CBLC-102; Curaxin CBLC-102 Approved Bayer AG Atebrin, Maladin, Atabrine, Tenicridine Lupus Erythematosus, Systemic; Giardiasis; Leishmaniasis; Malaria Bayer AG 1932-01-01 Creutzfeldt-Jakob Syndrome; Carcinoma, Renal Cell; Malaria; Giardiasis; Lupus Erythematosus, Systemic; Prostatic Neoplasms; Leishmaniasis Details
Anapsos EQA-00 Approved Asac Pharmaceutical International Psoriacen Psoriasis; Dermatitis, Atopic Asac Pharmaceutical International 1972-01-01 Psoriasis; Dermatitis, Atopic Details
Acetylaconitine Approved Mainland China Pain Shaanxi Xingbang Pharmacevtical Co Ltd 1985-01-01 Pain Details
Andrographolide/Sodium Hydrogen Sulfite Approved Bacterial Infections Details
Glucosamine Hydrochloride/Chondroitin sulfate Approved Details
Glucosamine Hydrochloride/Indomethacin Approved Mainland China Spondylitis, Ankylosing; Spondylosis; Periarthritis; Arthritis, Rheumatoid; Arthritis null 1995-01-01 Spondylitis, Ankylosing; Arthritis, Rheumatoid; Periarthritis; Arthritis; Spondylosis Details
Glucosamine Hydrochloride/Dermatan sulfate Approved Details
Iguratimod T-614 Approved Jiangsu Simcere Pharmaceutical Co Ltd 艾得辛, Colvet, Iremod, Kolbet, Careram Mainland China Arthritis, Rheumatoid Hainan Simcere Pharmaceutical Co Ltd 2011-08-15 Graft vs Host Disease; Sjogren's Syndrome; Arthritis, Rheumatoid Details
Anvirzel Approved Nerium Biotechnology Inc, Ozelle Pharmaceuticals Inc Anvirzel Neoplasms Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Edasalonexent CAT-1004 Phase 3 Clinical Catabasis Pharmaceuticals Inc Diabetes Mellitus, Type 2; Muscular Dystrophy, Duchenne Details
NF-kappa-B decoy oligonucleotide MP-40; MP-41; MP-42; AMS-001; SI-3104; AMG-0101; AMG-0102; AMG-0103; S-414114 Phase 3 Clinical Anges Mg, Osaka University Intervertebral Disc Degeneration; Dermatitis, Atopic Details
RGN-259 Fx peptide; TB4 16-38; RGN-457; Thymosin beta 4-16-38; Thymosin B4; RGN-352; RGN-259; RGN-137; Tβ4; TB4; GBT-201; GBT-101; Thymosin beta4 Phase 3 Clinical National Institutes Of Health Keratitis; Myocardial Ischemia; ST Elevation Myocardial Infarction; Myocardial Infarction; Graft vs Host Disease; Sjogren's Syndrome; Dry Eye Syndromes; Epidermolysis Bullosa; Pressure Ulcer; Epidermolysis Bullosa, Junctional; Varicose Ulcer; Diabetes Mellitus; Epidermolysis Bullosa Dystrophica Details
Dazdotuftide TRS-01 Phase 3 Clinical Tarsius Pharma Glaucoma; Uveitis, Anterior; Uveitis; Ocular inflammation Details
Bardoxolone Methyl RTA-402; NSC-713200 Phase 3 Clinical Kyowa Hakko Kirin Co Ltd, Reata Pharmaceuticals Inc Cryptogenic Organizing Pneumonia; Melanoma; Kidney Failure, Chronic; Nephritis, Hereditary; Hamman-Rich Syndrome; Lymphoma; Renal Insufficiency, Chronic; Hepatic Insufficiency; Diabetic Nephropathies; Polycystic Kidney, Autosomal Dominant; Glomerulosclerosis, Focal Segmental; Pulmonary Arterial Hypertension; Hypertension, Pulmonary; Lung Diseases, Interstitial; Liver Diseases; Coronavirus Disease 2019 (COVID-19); Sarcoidosis; Idiopathic Pulmonary Fibrosis; Pancreatic Neoplasms; Kidney Diseases; Glomerulonephritis, IGA; Idiopathic Interstitial Pneumonias; Diabetes Mellitus, Type 2; Solid tumours Details
Hypochlorous Acid PR-013; PR-022 Phase 3 Clinical Realm Therapeutics Cataract; Virus Diseases; Coronavirus Disease 2019 (COVID-19); Endophthalmitis; Conjunctivitis, Allergic; Dermatitis, Atopic Details
Triolex HE-3286; NE-3107 Phase 3 Clinical Harbor Therapeutics, Biovie Inc Brain Injuries, Traumatic; Diabetes Mellitus, Type 2; Arthritis, Rheumatoid; Insulin Resistance; Alzheimer Disease; Colitis, Ulcerative; Parkinson Disease Details
Fluasterone ST002; ST001; ST-001; HE-2500; 8354; ST-002 Phase 2 Clinical Harbor Keratosis, Actinic; Cushing Syndrome; Metabolic Syndrome Details
Nanocurcumin (Tehran University of Medical Sciences) Phase 2 Clinical Tehran University Of Medical Sciences Neoplasms; Periapical Diseases Details
APPA APPA; AKL-4; AKL-IV; APPA-1 Phase 2 Clinical AKL Research & Development Ltd Osteoarthritis Details
CKBA CKBA Phase 2 Clinical BCY Pharm Co Ltd Psoriasis; Vitiligo; Plaque psoriasis Details
Manganese butoxyethyl pyridyl porphyrin BMX-001; MnTnBuOE-2-PyP5+ Phase 2 Clinical Duke University Head and Neck Neoplasms; Rectal Neoplasms; Glioblastoma; Astrocytoma; Carcinoma, Squamous Cell; Glioma; Brain metastases Details
CBL-0137 CX-137; CBL-0137; CBLC-137; Curaxin-CBL0137 Phase 2 Clinical Cleveland Biolabs Inc Solid tumours; Hematologic Neoplasms; Skin Melanoma; Neoplasms; Glioblastoma; Central Nervous System Neoplasms; Osteosarcoma; Sarcoma; Diffuse Intrinsic Pontine Glioma; Lymphoma; Glioma; Melanoma Details
Ornithine Phenylacetate OP; L-OP; OCR-002; UCL-L1V; MNK-6105; MNK-6106 Phase 2 Clinical University College London Liver Cirrhosis; Fibrosis; Hepatic Encephalopathy Details
Tepilamide fumarate PPC-06; XP-23829 Phase 2 Clinical Xenoport Inc Psoriasis Details
YIV-906 PHY-906; KD-018 Phase 2 Clinical Phytoceutica Inc Liver Neoplasms; Rectal Neoplasms; Pancreatic Neoplasms; Diarrhea; Hepatitis B; Colorectal Neoplasms; Carcinoma, Hepatocellular Details
GLS-1027 GIT-27; VGX-1027 Phase 2 Clinical Geneone Life Science Inc Pneumonia; Coronavirus Disease 2019 (COVID-19); Severe Acute Respiratory Syndrome Details
Dimethylaminomicheliolide Fumarate ACT-001 Phase 2 Clinical Tianjin Accendatech Technology Co Ltd Glioblastoma; Small Cell Lung Carcinoma; Ganglioglioma; Central Nervous System Neoplasms; Optic Neuritis; Neuromyelitis Optica; Breast Neoplasms; Glioma; Brain metastases; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Melanoma Details
Ascorbic Acid/Menadione Phase 2 Clinical Ic-Medtech Co, Summa Health System Joint Diseases; Prostatic Neoplasms Details
LC-280126 MIT-001; LC-280126; NecroX-7; LC28-0126 Phase 2 Clinical Lg Life Sciences Ltd Hematologic Neoplasms; ST Elevation Myocardial Infarction; Squamous Cell Carcinoma of Head and Neck; Multiple Myeloma; Lymphoma; Stomatitis Details
Ginsenoside C-K IH-901; Compound K Phase 1 Clinical Rohto, Il-Hwa, Zhejiang Hisun Pharmaceutical Co Ltd, Fudan University, State Pharmaceutical Administration of Shanghai Institute of Pharmaceutical Industry Arthritis, Rheumatoid Details
ORYN-1001 ORTD-1; ORYN-1001 Phase 1 Clinical Oryn Therapeutics Llc Coronavirus Disease 2019 (COVID-19); Arthritis, Rheumatoid Details
CKD-712 CKD-712 Phase 1 Clinical Chong Kun Dang Pharmaceutical Corp Sepsis Details
LH-025 LH-025 Phase 1 Clinical Dr August Wolff Colitis, Ulcerative Details
Xempritolimod KMRC-011 Phase 1 Clinical Korea Institute Of Industrial Technology Acute Radiation Syndrome Details
DEN-181 DEN-181; CurcusomeRA; CurcusomeTMRA Phase 1 Clinical Dendright Arthritis, Rheumatoid Details
ILB-202 ILB-202; ILB202 Phase 1 Clinical Ilias Biologics Inc Acute Kidney Injury; Intraoperative Complications Details
SFA-001 SFA-001; SFA-001N Phase 1 Clinical Temple University, Sfa Therapeutics Metabolic Dysfunction-Associated Steatotic Liver Disease; Fibrosis Details
Proximod Phase 1 Clinical Institue Of Materia Medica Chinese Academy Of Medical Science Arthritis, Rheumatoid Details
[14C]ACT-001 [14C]ACT001 Phase 1 Clinical Tianjin Xinyi Shangde Biomedical Technology Co Ltd Solid tumours Details
RHN-002 RHN-002; RHN002 Phase 1 Clinical RH Nanopharmaceuticals LLC Pain, Postoperative; Anemia, Sickle Cell Details
Hypochlorous Acid/Acetic Acid SS0350; SS-0350 Phase 1 Clinical Softox Solutions As Leg Ulcer; Varicose Ulcer Details
TLZ-16-CL TLZ-16-CL Phase 1 Clinical Beijing Taizhou Lize Pharmaceutical Technology Co Ltd Substance Withdrawal Syndrome; Cocaine-Related Disorders Details
OP-101 OP-101 Phase 1 Clinical Ashvattha Therapeutics Coronavirus Disease 2019 (COVID-19); Adrenoleukodystrophy Details
Anatabine citrate RCP-006 Clinical Rock Creek, Roskamp Institute Thyroiditis, Autoimmune; Smoking Cessation; Tobacco Use Disorder; Alzheimer Disease; Inflammation Details
Tarenflurbil spraygel (MIKA Pharma) Clinical Galen Ltd, Mika Pharma Gmbh Pain; Arthritis, Rheumatoid; Skin Diseases; Inflammation; Dermatitis, Atopic Details
RHN-001 RHN-001; RHN001 RH Nanopharmaceuticals LLC Details
Edasalonexent CAT-1004 Phase 3 Clinical Catabasis Pharmaceuticals Inc Diabetes Mellitus, Type 2; Muscular Dystrophy, Duchenne Details
NF-kappa-B decoy oligonucleotide MP-40; MP-41; MP-42; AMS-001; SI-3104; AMG-0101; AMG-0102; AMG-0103; S-414114 Phase 3 Clinical Anges Mg, Osaka University Intervertebral Disc Degeneration; Dermatitis, Atopic Details
RGN-259 Fx peptide; TB4 16-38; RGN-457; Thymosin beta 4-16-38; Thymosin B4; RGN-352; RGN-259; RGN-137; Tβ4; TB4; GBT-201; GBT-101; Thymosin beta4 Phase 3 Clinical National Institutes Of Health Keratitis; Myocardial Ischemia; ST Elevation Myocardial Infarction; Myocardial Infarction; Graft vs Host Disease; Sjogren's Syndrome; Dry Eye Syndromes; Epidermolysis Bullosa; Pressure Ulcer; Epidermolysis Bullosa, Junctional; Varicose Ulcer; Diabetes Mellitus; Epidermolysis Bullosa Dystrophica Details
Dazdotuftide TRS-01 Phase 3 Clinical Tarsius Pharma Glaucoma; Uveitis, Anterior; Uveitis; Ocular inflammation Details
Bardoxolone Methyl RTA-402; NSC-713200 Phase 3 Clinical Kyowa Hakko Kirin Co Ltd, Reata Pharmaceuticals Inc Cryptogenic Organizing Pneumonia; Melanoma; Kidney Failure, Chronic; Nephritis, Hereditary; Hamman-Rich Syndrome; Lymphoma; Renal Insufficiency, Chronic; Hepatic Insufficiency; Diabetic Nephropathies; Polycystic Kidney, Autosomal Dominant; Glomerulosclerosis, Focal Segmental; Pulmonary Arterial Hypertension; Hypertension, Pulmonary; Lung Diseases, Interstitial; Liver Diseases; Coronavirus Disease 2019 (COVID-19); Sarcoidosis; Idiopathic Pulmonary Fibrosis; Pancreatic Neoplasms; Kidney Diseases; Glomerulonephritis, IGA; Idiopathic Interstitial Pneumonias; Diabetes Mellitus, Type 2; Solid tumours Details
Hypochlorous Acid PR-013; PR-022 Phase 3 Clinical Realm Therapeutics Cataract; Virus Diseases; Coronavirus Disease 2019 (COVID-19); Endophthalmitis; Conjunctivitis, Allergic; Dermatitis, Atopic Details
Triolex HE-3286; NE-3107 Phase 3 Clinical Harbor Therapeutics, Biovie Inc Brain Injuries, Traumatic; Diabetes Mellitus, Type 2; Arthritis, Rheumatoid; Insulin Resistance; Alzheimer Disease; Colitis, Ulcerative; Parkinson Disease Details
Fluasterone ST002; ST001; ST-001; HE-2500; 8354; ST-002 Phase 2 Clinical Harbor Keratosis, Actinic; Cushing Syndrome; Metabolic Syndrome Details
Nanocurcumin (Tehran University of Medical Sciences) Phase 2 Clinical Tehran University Of Medical Sciences Neoplasms; Periapical Diseases Details
APPA APPA; AKL-4; AKL-IV; APPA-1 Phase 2 Clinical AKL Research & Development Ltd Osteoarthritis Details
CKBA CKBA Phase 2 Clinical BCY Pharm Co Ltd Psoriasis; Vitiligo; Plaque psoriasis Details
Manganese butoxyethyl pyridyl porphyrin BMX-001; MnTnBuOE-2-PyP5+ Phase 2 Clinical Duke University Head and Neck Neoplasms; Rectal Neoplasms; Glioblastoma; Astrocytoma; Carcinoma, Squamous Cell; Glioma; Brain metastases Details
CBL-0137 CX-137; CBL-0137; CBLC-137; Curaxin-CBL0137 Phase 2 Clinical Cleveland Biolabs Inc Solid tumours; Hematologic Neoplasms; Skin Melanoma; Neoplasms; Glioblastoma; Central Nervous System Neoplasms; Osteosarcoma; Sarcoma; Diffuse Intrinsic Pontine Glioma; Lymphoma; Glioma; Melanoma Details
Ornithine Phenylacetate OP; L-OP; OCR-002; UCL-L1V; MNK-6105; MNK-6106 Phase 2 Clinical University College London Liver Cirrhosis; Fibrosis; Hepatic Encephalopathy Details
Tepilamide fumarate PPC-06; XP-23829 Phase 2 Clinical Xenoport Inc Psoriasis Details
YIV-906 PHY-906; KD-018 Phase 2 Clinical Phytoceutica Inc Liver Neoplasms; Rectal Neoplasms; Pancreatic Neoplasms; Diarrhea; Hepatitis B; Colorectal Neoplasms; Carcinoma, Hepatocellular Details
GLS-1027 GIT-27; VGX-1027 Phase 2 Clinical Geneone Life Science Inc Pneumonia; Coronavirus Disease 2019 (COVID-19); Severe Acute Respiratory Syndrome Details
Dimethylaminomicheliolide Fumarate ACT-001 Phase 2 Clinical Tianjin Accendatech Technology Co Ltd Glioblastoma; Small Cell Lung Carcinoma; Ganglioglioma; Central Nervous System Neoplasms; Optic Neuritis; Neuromyelitis Optica; Breast Neoplasms; Glioma; Brain metastases; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Melanoma Details
Ascorbic Acid/Menadione Phase 2 Clinical Ic-Medtech Co, Summa Health System Joint Diseases; Prostatic Neoplasms Details
LC-280126 MIT-001; LC-280126; NecroX-7; LC28-0126 Phase 2 Clinical Lg Life Sciences Ltd Hematologic Neoplasms; ST Elevation Myocardial Infarction; Squamous Cell Carcinoma of Head and Neck; Multiple Myeloma; Lymphoma; Stomatitis Details
Ginsenoside C-K IH-901; Compound K Phase 1 Clinical Rohto, Il-Hwa, Zhejiang Hisun Pharmaceutical Co Ltd, Fudan University, State Pharmaceutical Administration of Shanghai Institute of Pharmaceutical Industry Arthritis, Rheumatoid Details
ORYN-1001 ORTD-1; ORYN-1001 Phase 1 Clinical Oryn Therapeutics Llc Coronavirus Disease 2019 (COVID-19); Arthritis, Rheumatoid Details
CKD-712 CKD-712 Phase 1 Clinical Chong Kun Dang Pharmaceutical Corp Sepsis Details
LH-025 LH-025 Phase 1 Clinical Dr August Wolff Colitis, Ulcerative Details
Xempritolimod KMRC-011 Phase 1 Clinical Korea Institute Of Industrial Technology Acute Radiation Syndrome Details
DEN-181 DEN-181; CurcusomeRA; CurcusomeTMRA Phase 1 Clinical Dendright Arthritis, Rheumatoid Details
ILB-202 ILB-202; ILB202 Phase 1 Clinical Ilias Biologics Inc Acute Kidney Injury; Intraoperative Complications Details
SFA-001 SFA-001; SFA-001N Phase 1 Clinical Temple University, Sfa Therapeutics Metabolic Dysfunction-Associated Steatotic Liver Disease; Fibrosis Details
Proximod Phase 1 Clinical Institue Of Materia Medica Chinese Academy Of Medical Science Arthritis, Rheumatoid Details
[14C]ACT-001 [14C]ACT001 Phase 1 Clinical Tianjin Xinyi Shangde Biomedical Technology Co Ltd Solid tumours Details
RHN-002 RHN-002; RHN002 Phase 1 Clinical RH Nanopharmaceuticals LLC Pain, Postoperative; Anemia, Sickle Cell Details
Hypochlorous Acid/Acetic Acid SS0350; SS-0350 Phase 1 Clinical Softox Solutions As Leg Ulcer; Varicose Ulcer Details
TLZ-16-CL TLZ-16-CL Phase 1 Clinical Beijing Taizhou Lize Pharmaceutical Technology Co Ltd Substance Withdrawal Syndrome; Cocaine-Related Disorders Details
OP-101 OP-101 Phase 1 Clinical Ashvattha Therapeutics Coronavirus Disease 2019 (COVID-19); Adrenoleukodystrophy Details
Anatabine citrate RCP-006 Clinical Rock Creek, Roskamp Institute Thyroiditis, Autoimmune; Smoking Cessation; Tobacco Use Disorder; Alzheimer Disease; Inflammation Details
Tarenflurbil spraygel (MIKA Pharma) Clinical Galen Ltd, Mika Pharma Gmbh Pain; Arthritis, Rheumatoid; Skin Diseases; Inflammation; Dermatitis, Atopic Details
RHN-001 RHN-001; RHN001 RH Nanopharmaceuticals LLC Details

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