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Your Position: Casa > ASGR1

ASGR1

Brief Information

Name:Asialoglycoprotein receptor 1
Target Synonym:C-type lectin domain family 4 member H1,HL-1,Hepatic lectin H1,ASGPR 1,ASGR1,Asialoglycoprotein Receptor 1,CLEC4H1,ASGP-R 1,ASGPR1,ASGPR
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:0
Lastest Research Phase:Preclinical

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Part of Bioactivity data

CHEK-ATP080-Cell-based assay
 ASGR1 FACS

Fig. FACS analysis of ASGR1 on HEK293/Human ASGR1 Stable Cell Line.
FACS assay shows that Anti-ASGR1 Antibody can bind to HEK293/Human ASGR1 Stable Cell Line. HEK293/Human ASGR1 Stable Cell Line was red line, Negative control HEK293 cells was grey line (QC tested).

AS1-M5255-SPR
 ASGR1 SPR

SARS-CoV-2 S1 protein NTD, His Tag (Cat. No. S1D-C52H6) immobilized on CM5 Chip can bind Mouse ASGR1 Protein, Fc Tag (Cat. AS1-M5255) with an affinity constant of 1.16 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

AS1-H5243-SPR
 ASGR1 SPR

Human ASGR1 / ASGPR1 Protein, His Tag (Cat. No. AS1-H5243) immobilized on CM5 Chip can bind SARS-CoV-2 S1 protein, His Tag with an affinity constant of 50.2 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Synonym Name

ASGP-R 1, ASGPR 1, C-type lectin domain family 4 member H1, Hepatic lectin H1, HL-1

Background

ASGPR, a transmembrane C-type lectin, recognizes a wide variety of ligands that contain either terminal galactose (Gal) or N-acetylgalactosamine (GalNAc) residues and has been identified as a highly selective receptor on hepatocytes. The ASGR is composed of both a major (ASGR1) and minor subunit (ASGR2). ASGR1 has been shown to be efficiently targeted to the plasma membrane and to undergo constitutive endocytosis and recycling and found mainly expressed in the human liver.

Clinical and Translational Updates

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