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Expression analysis of human FAP on HEK293/Human FAP Stable Cell Line by FACS.
Cell surface staining was performed on HEK293/Human FAP Stable Cell Line or negative control cell using anti-human FAP antibody followed by staining with PE anti-human IgG Fc Antibody.
5e5 of anti-FAP CAR-293 cells were stained with 100 μL of 1:25 dilution (4 μL stock solution in 100 μL FACS buffer) of PE-Labeled Human FAP, His Tag (Cat. No. FAP-HP245) and negative control protein respectively. PE signal was used to evaluate the binding activity (QC tested).
Anti-FAP Antibody, Mouse IgG2a (FAP5) captured on CM5 chip via anti-mouse antibodies surface can bind Rat FAP, His Tag (Cat. No. FAP-R5246) with an affinity constant of 0.839 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).
| Name | Research Code | Research Phase | Company | Indications | Clinical Trials |
|---|---|---|---|---|---|
| Talabostat | VbP; PT-100; BXCL-701 | Phase 2 Clinical | Point Therapeutics | Brain Neoplasms; Carcinoma, Non-Small-Cell Lung; Adenocarcinoma; Melanoma; Leukemia, Lymphocytic, Chronic, B-Cell; Neoplasms, Germ Cell and Embryonal; Neoplasm Metastasis; Carcinoma, Pancreatic Ductal; Carcinoma, Small Cell; Lung Neoplasms; Leukemia, Myeloid, Acute; Prostatic Neoplasms; Kidney Neoplasms; Sarcoma; Neuroblastoma; Neuroendocrine Tumors; Central Nervous System Neoplasms; Pancreatic Neoplasms; Myelodysplastic Syndromes; Skin Neoplasms; Ovarian Neoplasms; Liver Neoplasms; Solid tumours | Details |
| 68Ga-TCR-FAPI | 68Ga-TCR-FAPI | Phase 2 Clinical | Tumor Research Institute Chinese Academy Of Medical Sciences | Neoplasms; Medullary thyroid cancer (MTC) | Details |
| NTI-1309 | NTI-1309; LNTH-1363S; 64Cu-LNTH-1363S | Phase 2 Clinical | Noria Therapeutics Inc | Stomach Neoplasms; Esophageal Neoplasms; Pancreatic Neoplasms; Sarcoma; Colorectal Neoplasms | Details |
| 177Lu-EB-FAPI | 177Lu-EB-FAPI | Phase 2 Clinical | Zhejiang University | Pancreatic Neoplasms; Cholangiocarcinoma; Carcinoma, Pancreatic Ductal | Details |
| 177Lu-DOTA-EB-FAPI | Phase 2 Clinical | The First Affiliated Hospital Of Xiamen University | Solid tumours; Adenocarcinoma, Follicular; Thyroid Neoplasms; Thyroid Cancer, Papillary | Details | |
| [18F]FAPI-74 | FAPI-74; [18F]FAPI-74; Fluor-18-FAPI-74; F-18]FAPI-74 | Phase 2 Clinical | University Of Heidelberg | Biliary Tract Neoplasms; Ovarian Neoplasms; Dermatomyositis; Stomach Neoplasms; Pheochromocytoma; Pancreatic Neoplasms; Urinary Bladder Neoplasms; Cholangiocarcinoma; Colorectal Neoplasms; Carcinoma, Pancreatic Ductal; Gastrointestinal Neoplasms; Carcinoma, Hepatocellular | Details |
| [18F]fibronstatin | 18F-LNC1005 | Phase 2 Clinical | Shanghai Lannacheng Biotechnology Co Ltd | Solid tumours; Diagnostic agents | Details |
| 68Ga-FAP-2286 | 68-Ga-FAP-2286; 68Ga-FAP-2286 | Phase 2 Clinical | 3B Pharmaceuticals GmbH | Solid tumours; Neoplasm Metastasis | Details |
| 68Ga-FAPI-46 | [68Ga]FAPI-46; 68Ga-FAPI-46 | Phase 2 Clinical | Karolinska University Hospital | Neoplasms; Carcinoma, Hepatocellular; Alveolitis, Extrinsic Allergic; Pneumoconiosis; Carcinoma, Pancreatic Ductal; Bile Duct Neoplasms; Carcinoma, Intraductal, Noninfiltrating; Pulmonary Fibrosis; Lung Diseases, Interstitial; Carcinoma, Ovarian Epithelial; Adenomatous Polyposis Coli; Pancreatic Neoplasms; Pneumonia; Stomach Neoplasms; Esophageal Neoplasms; Metabolic Dysfunction-Associated Steatotic Liver Disease; Radiation Pneumonitis; Idiopathic Interstitial Pneumonias; Ovarian Neoplasms | Details |
| 177Lu-FAP-2286 | 177Lu-FAP-2286 | Phase 2 Clinical | 3B Pharmaceuticals GmbH | Solid tumours | Details |
| RO-7122290 | RO-7122290; RG-7827 | Phase 2 Clinical | F. Hoffmann-La Roche Ltd | Colorectal Neoplasms | Details |
| NG-641 | EnAd-FAP-BiTE; EnAd-FAP-Tac; NG-641; NG-aFAP | Phase 1 Clinical | Akamis Bio Ltd, University Of Oxford | Squamous Cell Carcinoma of Head and Neck; Neoplasms, Glandular and Epithelial; Neoplasm Metastasis | Details |
| Simlukafusp alfa | FAP-IL2v; RG-7461; aFAP-IL2v; RO-6874281; FAP-IL2v FP | Phase 1 Clinical | F. Hoffmann-La Roche Ltd | Head and Neck Neoplasms; Solid tumours; Esophageal Neoplasms; Carcinoma, Renal Cell; Breast Neoplasms; Uterine Cervical Neoplasms; Melanoma | Details |
| 68Ga-PNT-6555 | Phase 1 Clinical | Point Biopharma Inc | Solid tumours; Esophageal Neoplasms; Sarcoma; Colorectal Neoplasms; Carcinoma, Pancreatic Ductal; Melanoma | Details | |
| 68Ga-FAPI-XT-117 | Phase 1 Clinical | Beijing Xiantong International Technology Co Ltd | Solid tumours | Details | |
| 64Cu-FAPI-XT117 | Phase 1 Clinical | Beijing Xiantong International Technology Co Ltd | Solid tumours | Details | |
| OMTX-705 | OMTX-705 | Phase 1 Clinical | Oncomatryx Biopharma Sl | Solid tumours | Details |
| MP-0310 | MP-0310; AMG-506 | Phase 1 Clinical | Molecular Partners Ag, Amgen Inc | Solid tumours | Details |
| 68Ga-NI-FAPI | 68Ga-NI-FAPI | Phase 1 Clinical | First Affiliated Hospital Of Fujian Medical University | Neoplasms | Details |
| 177Lu-FAPI-RGD | 177Lu-FAPI-RGD | Phase 1 Clinical | Peking Union Medical College Hospital | Neoplasms | Details |
| 177Lu-JH04 | 177Lu-JH04 | Phase 1 Clinical | First Affiliated Hospital Of Fujian Medical University | Neoplasms | Details |
| Lutetium [177Lu]-FAP-75 | Lutetium [177Lu]-FAP-75 | Phase 1 Clinical | Fudan University | Solid tumours | Details |
| 68Ga-JH04 | 68Ga-JH04; JH-04 | Phase 1 Clinical | Bivision Pharmaceuticals Inc | Neoplasms | Details |
| 68Ga-FAPI-JH04 | 68Ga-FAPI-JH04 | Phase 1 Clinical | First Affiliated Hospital Of Fujian Medical University | Neoplasms | Details |
| 68Ga-PSFA | 68Ga-PSFA | Phase 1 Clinical | First Affiliated Hospital Of Chongqing Medical University | Adenomatous Polyposis Coli | Details |
| 68 Ga-OncoFAP-DOTAGA | 68 Ga-OncoFAP | Phase 1 Clinical | Blue Earth Diagnostics, Philochem | Solid tumours | Details |
| AAA-614 | AAA-614; FAP-2286 | Phase 1 Clinical | Novartis Ag | Solid tumours | Details |
| 18F-AlF-FAPi-04 | 18F-AlF-FAPi-04 | Phase 1 Clinical | Affiliated Hospital Of North Sichuan Medical College | Solid tumours | Details |
| 177Lu-EB-FAPI(Peking Union Medical College Hospital) | 177Lu-EB-FAPI(Peking Union Medical College Hospital) | Phase 1 Clinical | Peking Union Medical College Hospital | Neoplasm Metastasis | Details |
| 68Ga-FAPI(Peking Union Medical College Hospital) | 68Ga-FAPI(Peking Union Medical College Hospital) | Phase 1 Clinical | Peking Union Medical College Hospital | Neoplasm Metastasis | Details |
| [177Lu]Lu-XT117 | [177Lu]Lu-XT117 | Phase 1 Clinical | Beijing Xiantong International Technology Co Ltd | Solid tumours | Details |
| RTX-1363-S | RTX-1363S; RTX-1363-S | Phase 1 Clinical | Ratio Therapeutics Inc | Stomach Neoplasms; Pancreatic Neoplasms; Breast Neoplasms; Lung Neoplasms | Details |
| 68Ga/64Cu-FAPI-XT117 | 68Ga/64Cu-FAPI-XT117 | Phase 1 Clinical | Beijing Xiantong International Technology Co Ltd | Solid tumours | Details |
| 177Lu-LNC1004 | 177Lu-LNC1004; 177Lu-LNC-1004 | Phase 1 Clinical | Shanghai Lannacheng Biotechnology Co Ltd | Solid tumours | Details |
| 68Ga-FAPI-RGD | 68Ga-FAPI-RGD; 68Ga-LNC-1007 | Phase 1 Clinical | Peking Union Medical College Hospital, Fujian Medical University | Carcinoma, Renal Cell; Neoplasms; Lung Neoplasms | Details |
| SHR-7367 | SHR7367; SHR-7367 | Phase 1 Clinical | Shanghai Hengrui Pharmaceutical Co Ltd | Solid tumours; Neoplasms | Details |
| 177Lu-PNT6555(Point Biopharma) | PNT-6555 | Phase 1 Clinical | Point Biopharma Inc | Skin Melanoma; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Esophageal Neoplasms; Sarcoma; Cholangiocarcinoma; Colorectal Neoplasms; Carcinoma, Pancreatic Ductal | Details |
| RO-7300490 | RO-7300490; RG-6189; FAP-CD40; FAP-huCD40 | Phase 1 Clinical | F. Hoffmann-La Roche Ltd | Solid tumours | Details |
| anti-BCMA/NKG2DL/FAP TCR T-cell therapy (Guangdong VitaLife) | Clinical | Multiple Myeloma | Details | ||
| 177Lu-BRP-010 | BRP-010; 177Lu-BRP-010 | Clinical | BoomRay Pharmaceuticals Co Ltd | Solid tumours | Details |
| 68Ga-BRP-010 | BRP-010; 68Ga-BRP-010 | Clinical | BoomRay Pharmaceuticals Co Ltd | Solid tumours | Details |
| [90Y] YFAPI-46 | Clinical | German Cancer Consortium (Dktk), University of Duisburg-Essen | Solid tumours | Details | |
| 3BP-3940 | 3BP-3940 | Clinical | Johannes Gutenberg University Of Mainz, 3B Pharmaceuticals GmbH | Neoplasms | Details |
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