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A-Z
> Eje de señalización TIGIT
TIGIT (inmunorreceptor de células T con dominios lg e ITIM) es una proteína del punto del control inmunitario recientemente descubierta que se expresa en las células T y en las células asesinas naturales (NK). TIGIT es un receptor inhibidor que modula la actividad inmunitaria compitiendo con el receptor activador CD226 (también conocido como DNAM-1) para la unión del ligando. Este interruptor de encendido y apagado de TIGIT y DNAM-1 es paralelo al de CTLA4 & CD28, lo que lo convierte en un objetivo prometedor para la terapia antitumoral.
CD155 (PVR) y CD112 (PVRL2 o Nectina-2) son co-ligandos de TIGIT y DNAM-1, mientras que CD113 (PVRL3 o Nectin-3) sólo se une a TIGIT. La afinidad entre los diferentes ligandos y los receptores varía. La unión entre TIGIT y CD155 es más robusta que la unión entre TIGIT y CD112 o CD113.
ACROBiosystems dispone de una amplia colección de proteínas recombinantes del eje de señalización TIGIT. A continuación encontrará información detallada:
Fig.1 FACS assay shows Biotinylated Human TIGIT, Fc,Avitag (Cat. No. TIT-H82F1) can bind to 293T cell overexpressing human CD155. The concentration of TIGIT is 0.03 μg/mL.
Fig.2 FACS assay shows that Human TIGIT, Mouse IgG2a Fc tag, low endotoxin (Cat. No. TIT-H5253) can bind to 293T cell overexpressing human CD155. The concentration of TIGIT used is 0.03 μg/mL.
Fig.3 Anti-hTIGIT antibody captured on CM5 chip via Anti-mouse antibodies surface can bind Human TIGIT, His Tag (Cat. No. TIT-H52H5) with an affinity constant of 1.28 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).
Fig.4 Serial dilutions of Anti-TIGIT Neutralizing antibody (Catalog # EP131-C04) (1:1 serial dilution, from 5 μg/mL to 0.01μg/mL) was added into TIGIT: Biotinylated CD155 binding reactions. The assay was performed according to the protocol described below. Background was subtracted from data points prior to log transformation and curve fitting (QC tested).
| Cat. No. | Species | Product Description | Structure | Purity | Features |
|---|---|---|---|---|---|
|
TIT-H82F1 (Biotin-labeled) |
|
Biotinylated Human TIGIT Protein, Fc Tag, Avi Tag |
|
|
|
| TIT-C5223 |
|
Cynomolgus / Rhesus macaque TIGIT Protein |
|
|
|
| TIT-C5254 |
|
Cynomolgus / Rhesus macaque TIGIT Protein, Fc Tag |
|
|
|
| TIT-M52E6 |
|
Mouse TIGIT Protein, His Tag |
|
|
|
| TIT-M5257 |
|
Mouse TIGIT Protein, Fc Tag |
|
|
|
| TIT-R5258 |
|
Rat TIGIT Protein, Fc Tag |
|
|
|
| TIT-R5259 |
|
Rabbit TIGIT Protein, Fc Tag |
|
|
|
| TIT-H5253 |
|
Human TIGIT Protein, Mouse IgG2a Fc Tag, low endotoxin |
|
|
|
| TIT-H5254 |
|
Human TIGIT Protein, Fc Tag |
|
|
|
| TIT-C52H7 |
|
Canine TIGIT Protein, His Tag |
|
|
|
| Molecule | Cat. No. | Species | Product Description | Structure | Purity | Features |
|---|---|---|---|---|---|---|
| CD155 | CD5-H82F6 |
|
Biotinylated Human CD155 / PVR Protein, Fc, Avi Tag |
|
|
|
| CD5-R52H5 |
|
Rhesus macaque CD155 / PVR Protein, His Tag |
|
|
|
|
| CD5-H5254 |
|
Human CD155 / PVR Protein, Mouse IgG2a Fc Tag, low endotoxin |
|
|
|
|
| CD5-M5254 |
|
Mouse CD155 / PVR Protein, Mouse IgG2a Fc Tag |
|
|
|
|
| CD5-H82E3 |
|
Biotinylated Human CD155 / PVR Protein, His, Avitag™ |
|
|
|
|
| CD5-M82F7 |
|
Biotinylated Mouse CD155 / PVR Protein, Fc, Avitag™ |
|
|
|
|
| CD5-H5251 |
|
Human CD155 / PVR Protein, Fc Tag |
|
|
|
|
| CD5-H5223 |
|
Human CD155 / PVR Protein, His Tag |
|
|
||
| CD112 | CD2-H82F8 |
|
Biotinylated Human Nectin-2 / CD112 Protein, Fc, Avi Tag |
|
|
|
| CD2-H5257 |
|
Human Nectin-2 / CD112 Protein, Mouse IgG2a Fc Tag |
|
|
|
|
| PV2-H5253 |
|
Human Nectin-2 / CD112 Protein, Fc Tag |
|
|
|
|
| PV2-H52E2 |
|
Human Nectin-2 / CD112 Protein, His Tag |
|
|
|
|
| CD113 | PV3-H82F3 |
|
Biotinylated Human Nectin-3 / CD113 Protein, Fc, Avi Tag |
|
|
|
| PV3-H5255 |
|
Human Nectin-3 / CD113 Protein, Fc Tag |
|
|
|
|
| PV3-H52E4 |
|
Human Nectin-3 / CD113 Protein, His Tag |
|
|
|
|
| DNAM-1 | DN1-H82F9 |
|
Biotinylated Human DNAM-1 / CD226 Protein, Fc, Avi Tag |
|
|
|
| DN1-C52H9 |
|
Cynomolgus DNAM-1 / CD226 Protein, His Tag |
|
|
|
|
| DN1-H5257 |
|
Human DNAM-1 / CD226 Protein, Fc Tag |
|
|
|
|
| DN1-H52H6 |
|
Human DNAM-1 / CD226 Protein, His Tag |
|
|
|
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