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| ID | Components | Size |
| EP155-C01 | High-bind Plate | 1 plate |
| EP155-C02 | Human Integrin α 4 β 7 | 25 μg |
| EP155-C03 | Biotinylated Human MAdCAM-1 | 10 μg |
| EP155-C04 | Anti-Integrin α 4 β 7 Neutralizing Antibody | 20 μg |
| EP155-C05 | Streptavidin-HRP | 5 μg |
| EP155-C06 | Coating Buffer | 12 mL |
| EP155-C07 | 10xWashing Buffer | 50 mL |
| EP155-C08 | Blocking Buffer | 50 mL |
| EP155-C09 | Substrate Solution | 12 mL |
| EP155-C10 | Stop Solution | 7 mL |
| EP155-C11 | 1mol/L CaCl₂ | 1.5 mL |
| EP155-C12 | 1mol/L MgCl₂ | 1.5 mL |
| EP155-C13 | 1mol/L MnCl₂ | 1.5 mL |
This kit is developed for screening for inhibitors of human Integrin α 4 β 7 binding to human MAdCAM-1.
It is for research use only.
The opened kit should be stored per components table. The shelf life is 30 days from the date of opening.
Your experiment will include 4 simple steps:
a) Coat the plate with human Integrin α 4 β 7.
b) Add your molecule of interest to the tests.
c) Add human MAdCAM-1-Biotin to bind the coated Integrin α 4 β 7.
d) Add Streptavidin-HRP followed by TMB or other colorimetric HRP substrate.
Finally, the half maximal inhibitory concentration (IC50) of your compound to Integrin α 4 β 7:MAdCAM-1 binding will be determined by comparing OD readings among different experimental groups.
INHIBITION OF Integrin α 4 β 7: MAdCAM-1 [Biotinylated] BINDING BY ANTI-Integrin α 4 β 7 NEUTRALIZING ANTIBODY
Serial dilutions of Anti-Integrin α 4 β 7 Neutralizing antibody (Catalog # EP155-C04) (1:1 serial dilution, from 5 μg/mL to 0.0098μg/mL) was added into Integrin α 4 β 7: Biotinylated MAdCAM-1 binding reactions. The assay was performed according to the protocol described below. Background was subtracted from data points prior to log transformation and curve fitting (QC tested).
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