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| Project Name | Project Stage | Molecule Type | Host Species | Therapeutic Area | Indications |
| CD7 VHH - 01 | Lead | Hematological Malignancy | Non-hodgkin lymphoma |
5e5 of anti-CD7 CAR-293 cells were stained with 100 μL of 1:50 dilution (2 μL stock solution in 100 μL FACS buffer) of PE-Labeled Human CD7 Protein, His Tag (Cat. No. CD7-HP2H6) and negative control protein respectively (Fig. C and B), and non-transfected 293 cells were used as a control (Fig. A). PE signal was used to evaluate the binding activity (QC tested).
Cynomolgus CD7 Protein, His Tag (Cat. No. CD7-C52H7) immobilized on CM5 Chip can bind Human SECTM1, His Tag (Cat. No. SE1-H5227) with an affinity constant of 24.7 nM as determined in a SPR assay (Biacore 8K) (QC tested).
| Name | Research Code | Research Phase | Company | Indications | Clinical Trials |
|---|---|---|---|---|---|
| Anti-CD7 and anti-CD19 chimeric antigen receptor T cell therapy | GC-197 | Phase 2 Clinical | Gracell Biotechnologies (Shanghai) Co Ltd | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma | Details |
| BEAM-201 | BEAM-201 | Phase 2 Clinical | Beam Therapeutics Inc | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Leukemia, T-Cell | Details |
| Autologous and Donor-derived CD7 CAR-T Therapy(Beijing GoBroad Hospital) | Phase 2 Clinical | Beijing GoBroad Hospital | Precursor Cell Lymphoblastic Leukemia-Lymphoma; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma | Details | |
| CD7-CAR-T Cells Therapy | CD7-CART01 | Phase 2 Clinical | Bambino Gesu Hospital And Research Institute | Precursor Cell Lymphoblastic Leukemia-Lymphoma; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma | Details |
| Humanized CD7 CAR-T cells | Phase 2 Clinical | The First Affiliated Hospital Of Soochow University | Lymphoma, T-Cell | Details | |
| WU-CART-007 | WU-CART-007 | Phase 2 Clinical | Wugen Inc | Lymphoma, T-Cell, Peripheral; Enteropathy-Associated T-Cell Lymphoma; Leukemia-Lymphoma, Adult T-Cell; Lymphoma, Primary Cutaneous Anaplastic Large Cell; Lymphoma, Extranodal NK-T-Cell; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sezary Syndrome; Lymphoma, Large-Cell, Anaplastic; Leukemia, Myeloid, Acute; Lymphoma, T-Cell; Leukemia, Prolymphocytic, T-Cell; Mycosis Fungoides | Details |
| Anti-CD7 CAR T-cell therapy (Yake Biotechnology) | Phase 2 Clinical | Shanghai YaKe Biotechnology Co Ltd | Leukemia; Still's Disease, Adult-Onset; Hematologic Diseases; Dermatomyositis; Neoplasms; Autoimmune Diseases; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Colitis, Ulcerative; Lymphoma; Lymphoma, T-Cell; Crohn Disease; Leukemia, T-Cell | Details | |
| CD7-CAR-T cell therapy (PersonGen Biomedicine) | Phase 2 Clinical | Persongen Biotherapeutics (Suzhou) Co Ltd, The First Affiliated Hospital Of Zhengzhou University | Leukemia; Enteropathy-Associated T-Cell Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Lymphoma, Extranodal NK-T-Cell; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Lymphoma, Large-Cell, Anaplastic; Leukemia, Myeloid, Acute; Lymphoma, T-Cell | Details | |
| GC-027 | GC-027 | Phase 1 Clinical | Gracell Biotechnologies (Shanghai) Co Ltd | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma | Details |
| MB-107(March Biosciences) | MB-107(March Biosciences) | Phase 1 Clinical | March Biosciences Inc | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Lymphoma, T-Cell | Details |
| Universal 4SCAR7U T Cell Therapy (Shenzhen Geno-Immune Medical Institute) | 4SCAR7U T cells | Phase 1 Clinical | Shenzhen Geno-Immune Medical Institute | Precursor Cell Lymphoblastic Leukemia-Lymphoma; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Leukemia, Myeloid, Acute; Lymphoma | Details |
| RD13-02 | RD13-02 | Phase 1 Clinical | Nanjing Bioheng Biotech Co Ltd, Zhejiang University | Hematologic Neoplasms; Hematologic Diseases; Neoplasms | Details |
| Anti-CD7 Chimeric Antigen Receptor T-Cell therapy(Bioceltech Therapeutics) | BT-007 | Phase 1 Clinical | Gracell Biotechnologies (Shanghai) Co Ltd, Bioceltech Therapeutics Ltd | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma | Details |
| BE CAR-7 | BE-CAR-7 | Phase 1 Clinical | Great Ormond Street Hospital For Children Nhs Foundation Trust | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Leukemia, Prolymphocytic, T-Cell | Details |
| Anti-CD7 CAR-T cell Therapy (Shanghai General Hospital) | Phase 1 Clinical | Shanghai General Hospital | Lymphoma, T-Cell, Peripheral; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Lymphoma, Large-Cell, Anaplastic; Leukemia, T-Cell | Details | |
| This CAR-T-7 cells therapy | This CAR-T-7 cells | Phase 1 Clinical | Fundamenta Therapeutics Ltd | Leukemia, Lymphoid; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Lymphoma, T-Cell | Details |
| GC-502 | GC-502 | Phase 1 Clinical | Gracell Biotechnologies (Shanghai) Co Ltd | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Lymphoma, Non-Hodgkin | Details |
| CD7 CARvac T cell therapy | Phase 1 Clinical | Icell Gene Therapeutics (Int'L) Ltd | Hematologic Neoplasms; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Lymphoma | Details | |
| SenL-T7 CAR T Cells (Hebei Senlang Biological) | Senl-T7; Senl-T-7; SENL-101 | Phase 1 Clinical | Hebei Senlang Biological Technology Co Ltd | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Lymphoma, T-Cell; Leukemia, T-Cell | Details |
| PA3-17 | PA3-17; PA-3-17; PA3-17 (autologous) | Phase 1 Clinical | Persongen Anke Cell Technology Co Ltd, Persongen Biotherapeutics (Suzhou) Co Ltd | Hematologic Neoplasms; Lymphoma | Details |
| CAR7-T Cell Therapy (Beijing Gaobo Biotechnology Co Ltd) | Phase 1 Clinical | Wuhan Union Hospital | Lymphoma, T-Cell; Leukemia, T-Cell; Leukemia, Lymphocytic, Chronic, B-Cell | Details | |
| CD7 targeted CAR-γδ T cells therapy(Persongen Bio) | Phase 1 Clinical | Persongen Biotherapeutics (Suzhou) Co Ltd | Neoplasms; Leukemia, B-Cell | Details | |
| CD7 CAR-T cell therapy (Hebei Senlang Biotechnology) | Phase 1 Clinical | Hebei Senlang Biological Technology Co Ltd | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma | Details | |
| RD13-01 | RD13-01; CTD-401 | Clinical | Zhejiang University, Nanjing Bioheng Biotech Co Ltd | Hematologic Neoplasms | Details |
| Anti-CD7 CAR-T Cell Therapy (iCell Gene Therapeutics) | iCell Gene Therapeutics LLC | Details | |||
| Anti-CD7 and anti-CD19 chimeric antigen receptor T cell therapy | GC-197 | Phase 2 Clinical | Gracell Biotechnologies (Shanghai) Co Ltd | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma | Details |
| BEAM-201 | BEAM-201 | Phase 2 Clinical | Beam Therapeutics Inc | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Leukemia, T-Cell | Details |
| Autologous and Donor-derived CD7 CAR-T Therapy(Beijing GoBroad Hospital) | Phase 2 Clinical | Beijing GoBroad Hospital | Precursor Cell Lymphoblastic Leukemia-Lymphoma; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma | Details | |
| CD7-CAR-T Cells Therapy | CD7-CART01 | Phase 2 Clinical | Bambino Gesu Hospital And Research Institute | Precursor Cell Lymphoblastic Leukemia-Lymphoma; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma | Details |
| Humanized CD7 CAR-T cells | Phase 2 Clinical | The First Affiliated Hospital Of Soochow University | Lymphoma, T-Cell | Details | |
| WU-CART-007 | WU-CART-007 | Phase 2 Clinical | Wugen Inc | Lymphoma, T-Cell, Peripheral; Enteropathy-Associated T-Cell Lymphoma; Leukemia-Lymphoma, Adult T-Cell; Lymphoma, Primary Cutaneous Anaplastic Large Cell; Lymphoma, Extranodal NK-T-Cell; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sezary Syndrome; Lymphoma, Large-Cell, Anaplastic; Leukemia, Myeloid, Acute; Lymphoma, T-Cell; Leukemia, Prolymphocytic, T-Cell; Mycosis Fungoides | Details |
| Anti-CD7 CAR T-cell therapy (Yake Biotechnology) | Phase 2 Clinical | Shanghai YaKe Biotechnology Co Ltd | Leukemia; Still's Disease, Adult-Onset; Hematologic Diseases; Dermatomyositis; Neoplasms; Autoimmune Diseases; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Colitis, Ulcerative; Lymphoma; Lymphoma, T-Cell; Crohn Disease; Leukemia, T-Cell | Details | |
| CD7-CAR-T cell therapy (PersonGen Biomedicine) | Phase 2 Clinical | Persongen Biotherapeutics (Suzhou) Co Ltd, The First Affiliated Hospital Of Zhengzhou University | Leukemia; Enteropathy-Associated T-Cell Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Lymphoma, Extranodal NK-T-Cell; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Lymphoma, Large-Cell, Anaplastic; Leukemia, Myeloid, Acute; Lymphoma, T-Cell | Details | |
| GC-027 | GC-027 | Phase 1 Clinical | Gracell Biotechnologies (Shanghai) Co Ltd | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma | Details |
| MB-107(March Biosciences) | MB-107(March Biosciences) | Phase 1 Clinical | March Biosciences Inc | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Lymphoma, T-Cell | Details |
| Universal 4SCAR7U T Cell Therapy (Shenzhen Geno-Immune Medical Institute) | 4SCAR7U T cells | Phase 1 Clinical | Shenzhen Geno-Immune Medical Institute | Precursor Cell Lymphoblastic Leukemia-Lymphoma; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Leukemia, Myeloid, Acute; Lymphoma | Details |
| RD13-02 | RD13-02 | Phase 1 Clinical | Nanjing Bioheng Biotech Co Ltd, Zhejiang University | Hematologic Neoplasms; Hematologic Diseases; Neoplasms | Details |
| Anti-CD7 Chimeric Antigen Receptor T-Cell therapy(Bioceltech Therapeutics) | BT-007 | Phase 1 Clinical | Gracell Biotechnologies (Shanghai) Co Ltd, Bioceltech Therapeutics Ltd | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma | Details |
| BE CAR-7 | BE-CAR-7 | Phase 1 Clinical | Great Ormond Street Hospital For Children Nhs Foundation Trust | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Leukemia, Prolymphocytic, T-Cell | Details |
| Anti-CD7 CAR-T cell Therapy (Shanghai General Hospital) | Phase 1 Clinical | Shanghai General Hospital | Lymphoma, T-Cell, Peripheral; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Lymphoma, Large-Cell, Anaplastic; Leukemia, T-Cell | Details | |
| This CAR-T-7 cells therapy | This CAR-T-7 cells | Phase 1 Clinical | Fundamenta Therapeutics Ltd | Leukemia, Lymphoid; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Lymphoma, T-Cell | Details |
| GC-502 | GC-502 | Phase 1 Clinical | Gracell Biotechnologies (Shanghai) Co Ltd | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Lymphoma, Non-Hodgkin | Details |
| CD7 CARvac T cell therapy | Phase 1 Clinical | Icell Gene Therapeutics (Int'L) Ltd | Hematologic Neoplasms; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Lymphoma | Details | |
| SenL-T7 CAR T Cells (Hebei Senlang Biological) | Senl-T7; Senl-T-7; SENL-101 | Phase 1 Clinical | Hebei Senlang Biological Technology Co Ltd | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Lymphoma, T-Cell; Leukemia, T-Cell | Details |
| PA3-17 | PA3-17; PA-3-17; PA3-17 (autologous) | Phase 1 Clinical | Persongen Anke Cell Technology Co Ltd, Persongen Biotherapeutics (Suzhou) Co Ltd | Hematologic Neoplasms; Lymphoma | Details |
| CAR7-T Cell Therapy (Beijing Gaobo Biotechnology Co Ltd) | Phase 1 Clinical | Wuhan Union Hospital | Lymphoma, T-Cell; Leukemia, T-Cell; Leukemia, Lymphocytic, Chronic, B-Cell | Details | |
| CD7 targeted CAR-γδ T cells therapy(Persongen Bio) | Phase 1 Clinical | Persongen Biotherapeutics (Suzhou) Co Ltd | Neoplasms; Leukemia, B-Cell | Details | |
| CD7 CAR-T cell therapy (Hebei Senlang Biotechnology) | Phase 1 Clinical | Hebei Senlang Biological Technology Co Ltd | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma | Details | |
| RD13-01 | RD13-01; CTD-401 | Clinical | Zhejiang University, Nanjing Bioheng Biotech Co Ltd | Hematologic Neoplasms | Details |
| Anti-CD7 CAR-T Cell Therapy (iCell Gene Therapeutics) | iCell Gene Therapeutics LLC | Details |
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