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| Project Name | Project Stage | Molecule Type | Host Species | Therapeutic Area | Indications |
| TIGIT&PVRIG BsAb - 01 | PCC | Solid Tumor | Solid tumor |
FACS assay shows that Human TIGIT, Mouse IgG2a Fc Tag (Cat. No. TIT-H5253) can bind to 293T cell overexpressing human CD155. The concentration of TIGIT used is 0.03 μg/mL (Routinely tested).
Anti-hTIGIT antibody captured on CM5 chip via Anti-mouse antibodies surface can bind Human TIGIT, His Tag (Cat. No. TIT-H52H5) with an affinity constant of 1.28 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).
| Name | Research Code | Research Phase | Company | Indications | Clinical Trials |
|---|---|---|---|---|---|
| Vibostolimab | MK-7684 | Phase 3 Clinical | Merck Sharp & Dohme Corp | Solid tumours; Small Cell Lung Carcinoma; Melanoma; Carcinoma, Non-Small-Cell Lung | Details |
| Domvanalimab | AB-154 | Phase 3 Clinical | Arcus Biosciences Inc | Carcinoma, Adenosquamous; Carcinoma, Hepatocellular; Melanoma; Gastrointestinal Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Lung Neoplasms; Esophageal adenocarcinoma; Cholangiocarcinoma; Biliary Tract Neoplasms; Urinary Bladder Neoplasms; Glioblastoma; Small Cell Lung Carcinoma; Pancreatic Neoplasms; Stomach Neoplasms; Esophageal Neoplasms; Solid tumours; Liver Neoplasms | Details |
| Tiragolumab | RO-7092284; MTIG-7192A; RG-6058 | Phase 3 Clinical | F. Hoffmann-La Roche Ltd | Carcinoma, Squamous Cell; Multiple Myeloma; Chordoma; Lymphoma, Follicular; Breast Neoplasms; Sarcoma; Esophageal Squamous Cell Carcinoma; Lymphoma, Non-Hodgkin; Mouth Neoplasms; Carcinoma, Medullary; Uterine Cervical Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Hepatocellular; Melanoma; Adenocarcinoma; Hemangioendothelioma, Epithelioid; Neoplasm Metastasis; Stomach Neoplasms; Liver Neoplasms; Teratoma; Lymphoma, B-Cell; Head and Neck Neoplasms; Carcinoma, Renal Cell; Carcinoma; Squamous Cell Carcinoma of Head and Neck; Rectal Neoplasms; Solid tumours; Esophageal Neoplasms; Rhabdoid Tumor; Carcinoma, Transitional Cell; Glioblastoma; Neoplasms; Small Cell Lung Carcinoma; Triple Negative Breast Neoplasms | Details |
| Pembrolizumab/Vibostolimab | MK-7684A | Phase 3 Clinical | Merck & Co Inc | Urinary Bladder Neoplasms; Carcinoma, Hepatocellular; Uterine Cervical Neoplasms; Carcinoma, Non-Small-Cell Lung; Melanoma; Gallbladder Neoplasms; Endometrial Neoplasms; Lung Neoplasms; Cholangiocarcinoma; Ovarian Neoplasms; Triple Negative Breast Neoplasms; Neoplasms; Small Cell Lung Carcinoma; Stomach Neoplasms; Esophageal Neoplasms; Squamous Cell Carcinoma of Head and Neck; Hematologic Neoplasms | Details |
| Rilvegostomig | AZD-2936 | Phase 3 Clinical | Astrazeneca Plc | Biliary Tract Neoplasms; Solid tumours; Stomach Neoplasms; Esophageal Neoplasms; Squamous Cell Carcinoma of Head and Neck; Bile Duct Neoplasms; Carcinoma, Non-Small-Cell Lung | Details |
| Ociperlimab | BGB-A1217 | Phase 3 Clinical | Beigene Ltd | Solid tumours; Biliary Tract Neoplasms; Lymphoma, B-Cell; Esophageal Neoplasms; Neoplasms; Small Cell Lung Carcinoma; Lymphoma, Large B-Cell, Diffuse; Cholangiocarcinoma; Nasopharyngeal Carcinoma; Esophageal Squamous Cell Carcinoma; Carcinoma, Non-Small-Cell Lung; Carcinoma, Hepatocellular; Uterine Cervical Neoplasms | Details |
| Etigilimab | OMP-313M32 | Phase 2 Clinical | Oncomed Pharmaceuticals Inc | Ovarian Neoplasms; Solid tumours; Neoplasms; Adenocarcinoma, Clear Cell; Peritoneal Neoplasms; Fallopian Tube Neoplasms; Neoplasm Metastasis | Details |
| Renvistobart | BMS-986207 | Phase 2 Clinical | Bristol-Myers Squibb Company | Solid tumours; Ovarian Neoplasms; Head and Neck Neoplasms; Endometrial Neoplasms; Carcinoma, Non-Small-Cell Lung | Details |
| ZG-005 | ZG-005 | Phase 2 Clinical | Gensun Biopharma Inc | Solid tumours; Neoplasms; Carcinoma, Neuroendocrine; Uterine Cervical Neoplasms | Details |
| HB-0036 | HB-0036 | Phase 2 Clinical | Solid tumours; Carcinoma, Non-Small-Cell Lung | Details | |
| AGEN-1777 | AGEN-1777; BMS-986442 | Phase 2 Clinical | Agenus Inc | Solid tumours; Neoplasms; Carcinoma, Non-Small-Cell Lung | Details |
| PM-1022 | PM-1022 | Phase 2 Clinical | Biotheus Inc | Neoplasms | Details |
| Lancastotug | AK-127 | Phase 2 Clinical | Zhongshan Akeso Biopharma Co Ltd | Solid tumours; Neoplasms; Carcinoma, Hepatocellular | Details |
| Belrestotug | EOS-448; EOS-884448; GSK-4428859; GSK-4428859A | Phase 2 Clinical | Iteos | Head and Neck Neoplasms; Small Cell Lung Carcinoma; Neoplasms; Multiple Myeloma; Lung Neoplasms; Carcinoma, Non-Small-Cell Lung; Melanoma | Details |
| HLX-301 | HLX-301 | Phase 2 Clinical | Shanghai Henlius Biologics Co Ltd | Solid tumours; Squamous Cell Carcinoma of Head and Neck; Esophageal Neoplasms; Small Cell Lung Carcinoma; Neoplasms; Lymphoma; Carcinoma, Non-Small-Cell Lung; Neoplasm Metastasis | Details |
| HLX-53 | HLX-53; HLX53 | Phase 2 Clinical | Shanghai Henlius Biologics Co Ltd | Solid tumours; Neoplasms; Lymphoma; Carcinoma, Hepatocellular; Neoplasm Metastasis | Details |
| HL-301 | HL-301 | Phase 2 Clinical | Hanlim Pharm Co Ltd | Radiation Pneumonitis; Small Cell Lung Carcinoma; Lung Neoplasms | Details |
| JS-006 | JS-006; TAB-006; CHS-006 | Phase 2 Clinical | Shanghai Junshi Biosciences Co Ltd | Solid tumours; Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung | Details |
| Dargistotug | M-6223; M6223 | Phase 2 Clinical | Emd Serono Research & Development Institute Inc | Solid tumours; Carcinoma, Transitional Cell; Neoplasm Metastasis | Details |
| DW-2008 | DW-2008; DW-2008S | Phase 1 Clinical | Dong Wha Pharm Co Ltd | Coronavirus Disease 2019 (COVID-19); Rhinitis, Allergic; Asthma | Details |
| Tamgiblimab | IBI-939 | Phase 1 Clinical | Innovent Biologics(Suzhou) Co Ltd | Neoplasms; Lung Neoplasms | Details |
| COM-902 | COM-902 | Phase 1 Clinical | Compugen Ltd | Ovarian Neoplasms; Squamous Cell Carcinoma of Head and Neck; Small Cell Lung Carcinoma; Neoplasms; Colonic Neoplasms; Multiple Myeloma; Neoplasms, Plasma Cell; Colorectal Neoplasms; Lung Neoplasms | Details |
| AK-130 | AK-130 | Phase 1 Clinical | Zhongshan Akeso Biopharma Co Ltd | Neoplasms; Carcinoma, Hepatocellular | Details |
| SIM-0348 | SIM-0348 | Phase 1 Clinical | Simcere Pharmaceutical Group Ltd | Solid tumours; Neoplasms | Details |
| Recombinant humanized anti-TIGIT monoclonal antibody(Lepu biopharma) | LP-010 | Phase 1 Clinical | Solid tumours | Details | |
| ASP-8374 | ASP-8374; PTZ-201 | Phase 1 Clinical | Potenza Therapeutics, Astellas Pharma Inc | Solid tumours; Glioblastoma | Details |
| ZGGS-15 | ZGGS15; ZGGS-15 | Phase 1 Clinical | Suzhou Zelgen Biopharmaceuticals Co Ltd | Solid tumours | Details |
| AUR-106 | AUR-106 | Phase 1 Clinical | Aurigene Discovery Technologies Ltd | Kidney Neoplasms; Esophageal Neoplasms; Stomach Neoplasms; Neoplasms; Carcinoma, Transitional Cell; Colonic Neoplasms; Carcinoma, Non-Small-Cell Lung | Details |
| BC008-1A | BC008-1A | Phase 1 Clinical | Sichuan Luzhou Buchang Biopharmaceutical Co Ltd | Solid tumours | Details |
| SHR-2002 | SHR-2002 | Phase 1 Clinical | Suzhou Suncadia Biopharmaceuticals Co Ltd, Shanghai Hengrui Pharmaceutical Co Ltd | Neoplasms | Details |
| PM-1021 | PM1021 | Phase 1 Clinical | Biotheus Inc | Solid tumours; Neoplasms | Details |
| SHS-006(Nanjing Sanhome Pharmaceutical) | SHS-006; SH-006; SH006 | Phase 1 Clinical | Nanjing Sanhome Pharmaceutical Co Ltd | Solid tumours | Details |
| HB0030 | HB-0030 | Phase 1 Clinical | Shanghai Huaota Biopharmaceutical Co Ltd | Solid tumours | Details |
| BAT-6005 | BAT-6005 | Phase 1 Clinical | Bio-Thera Solutions Ltd | Solid tumours | Details |
| IBI-321 | IBI-321 | Phase 1 Clinical | Innovent Biologics(Suzhou) Co Ltd | Solid tumours; Neoplasms | Details |
| Ralzapastotug | AB-308 | Phase 1 Clinical | Arcus Biosciences Inc | Solid tumours; Esophageal Neoplasms; Stomach Neoplasms; Lymphoma, Large B-Cell, Diffuse; Multiple Myeloma; Lymphoma, Non-Hodgkin; Carcinoma, Non-Small-Cell Lung; Uterine Cervical Neoplasms; Melanoma; Adenocarcinoma | Details |
| PM-1009 | PM1009 | Phase 1 Clinical | Biotheus Inc | Solid tumours; Neoplasms; Lung Neoplasms | Details |
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