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CCR8

Brief Information

Name:C-C chemokine receptor type 8
Target Synonym:Chemokine (C-C) Receptor 8,CC Chemokine Receptor 8,CDw198 Antigen,C-C CKR-8,CC-CKR-8,CCR-8,CMKBRL2,C-C Motif Chemokine Receptor 8,CC chemokine receptor CHEMR1,C-C chemokine receptor type 8,Chemokine (C-C Motif) Receptor 8,C-C Chemokine Receptor Type 8,CC Chemokine Receptor CHEMR1,Chemokine Receptor-Like 1,Chemokine (C-C) Receptor-Like 2,CC-Chemokine Receptor Chemr1,CD_antigen=CDw198,Chemokine receptor-like 1,CKRL1,CKR-L1,CMKBR8,GPRCY6,GPR-CY6,TER1,CDw198,CY6
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:12
Lastest Research Phase:Phase 2 Clinical

Antibody Licensing

Project Name Project Stage Molecule Type Host Species Therapeutic Area Indications
CCR8 mAb - 01 PCC Solid Tumor Solid tumor
CCR8 mAb - 02 Lead Solid Tumor Solid tumor
CCR8 mAb - 03 PCC Solid Tumor Solid tumor

Licensing

Project Name Modality Therapeutic Area Indications Stage Right Available
CCR8 Humanized Antibody Bispecific antibody Oncology/Cancer Solid Tumor Preclinical Global

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Cat. No. Especies Descripción del producto Estructura Pureza Característica
CHEK-ATP140 Human HEK293/Human CCR8 Stable Cell Line
CC8-H52P4 Human Human CCR8 Full Length Protein (VLP)
ACRO Quality

Part of Bioactivity data

CHEK-ATP140-Cell-based assay
 CCR8 FACS

Expression analysis of human CCR8 on HEK293/Human CCR8 Stable Cell Line by FACS.
Cell surface staining was performed on HEK293/Human CCR8 Stable Cell Line or negative control cell using anti-human CCR8 antibody followed by staining with PE anti-human IgG antibody.

CC8-H52P4-SPR
 CCR8 ELISA

Immobilized Human CCR8 Full Length Protein-VLP (Cat. No. CC8-H52P4) at 10 μg/mL (100 μL/well) can bind Anti-CCR8 Antibody, Human IgG1 with a linear range of 0.078-2.5 μg/mL (QC tested).

Synonym Name

CC chemokine receptor 8,CD198,,ChemR1,CKRL1,CKR-L1,CKRL1,CY6,GPRCL1,GPRCY6,GPR-CY6,TER-1

Background

This entry represents CC chemokine receptor 8 (CCR8), which it is expressed predominantly in lymphoid tissues and has also been found in glomerular podocytes and human umbilical vein endothelial cells (HUVECs). CCR8 is associated with Th2 lymphocytes, which are critical for allergy, and has a role in lymphocyte activation, migration, proliferation and differentiation and in allergic diseases. CCR8 binds to CCL1 (also known as I-309) and to CCL16 (also known as liver expressed chemokine). It also exhibits a high affinity for three chemokines of viral origin: vMIP-I, vMIP-II and vMCC-I.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
ZL-1218 ZL-1218 Phase 1 Clinical Zai Lab (Shanghai) Co Ltd Solid tumours; Neoplasms Details
BMS-986340 BMS-986340 Phase 2 Clinical Eeig Bristol-Myers Squibb Manufacturing Company Bristol-Myers Squibb Srl Ovarian Neoplasms; Squamous Cell Carcinoma of Head and Neck; Carcinoma, Renal Cell; Esophageal Neoplasms; Triple Negative Breast Neoplasms; Pancreatic Neoplasms; Carcinoma, Transitional Cell; Neoplasms; Colorectal Neoplasms; Uterine Cervical Neoplasms; Melanoma; Carcinoma, Non-Small-Cell Lung Details
ABBV-514 ABBV-514 Phase 1 Clinical Abbvie Inc Squamous Cell Carcinoma of Head and Neck; Carcinoma, Non-Small-Cell Lung Details
BAY-3375968 BAY-3375968 Phase 1 Clinical Bayer AG Solid tumours; Neoplasms Details
HBM-1022 HBM-1022 Phase 1 Clinical Harbour Biomed Neoplasms Details
JTX-1811 JTX-1811; GS-1811 Phase 1 Clinical Jounce Therapeutics Inc Solid tumours Details
IPG-7236 IPG-7236; IPG-007 Phase 1 Clinical Nanjing Immunophage Biotech Co Ltd Solid tumours; Breast Neoplasms; Dermatitis, Atopic Details
BGB-A3055 BGB-A3055 Phase 1 Clinical Beigene Ltd Solid tumours; Neoplasm Metastasis Details
S-531011 S-531011 Phase 2 Clinical Shionogi Inc Solid tumours Details
SRF-114 SRF-114 Phase 2 Clinical Surface Oncology Inc Solid tumours; Squamous Cell Carcinoma of Head and Neck; Neoplasms Details
ICP-B05 CM-369; ICPB05 Phase 1 Clinical Keymed Biosciences Co Ltd, InnoCare Pharma Ltd Hematologic Neoplasms; Solid tumours Details
LM-108 LM-108 Phase 2 Clinical LaNova Medicines Ltd Solid tumours Details

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