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Limited Edition Golden Llama is here! Check out how you can get one. Limited Edition Golden Llama is here! Check out how you can get one.
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This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 33.0 kDa. The protein migrates as 35-43 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
>95% as determined by SDS-PAGE.
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
Biotinylated Human Mesothelin (296-580), His Tag, primary amine labeling on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95% (With Star Ribbon Pre-stained Protein Marker).
Immobilized Anti-Human MSLN MAb at 0.5 μg/mL (100 μL/well) can bind Biotinylated Human Mesothelin (296-580), His Tag, primary amine labeling (Cat. No. MSN-H8223) with a linear range of 0.5-8 ng/mL (QC tested).
293 cells were transfected with anti-MSLN-scFv and RFP tag. 2e5 of the cells were first stained with B. Biotinylated Human Mesothelin (296-580), His Tag, primary amine labeling (Cat. No. MSN-H8223, 3 µg/mL) and C. Biotinylated Protein Control, followed by FITC Streptavidin. A. Non-transfected 293 cells and C. Biotinylated Protein Control were used as negative control. RFP was used to evaluate CAR (anti-MSLN-scFv) expression and FITC was used to evaluate the binding activity of Biotinylated Human Mesothelin (296-580), His Tag, primary amine labeling (Cat. No. MSN-H8223).
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English Name | Research Code | Research Phase | Company | First Brand Name | First Approved Country | First Indication | First Approved Company | First Approved Fecha | Indications | Clinical Trials |
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English Name | Research Code | Research Phase | Company | Indications | Clinical Trials |
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RC-88 | RC-88 | Phase 2 Clinical | RemeGen Co Ltd | Solid tumours; Neoplasms; Carcinoma, Ovarian Epithelial; Peritoneal Neoplasms; Fallopian Tube Neoplasms | Details |
iCasp9M28z | iCasp9M28z | Phase 2 Clinical | Memorial Sloan Kettering Cancer Center | Small Cell Lung Carcinoma; Pleural Diseases; Mesothelioma; Breast Neoplasms; Lung Neoplasms; Neoplasm Metastasis | Details |
Anetumab ravtansine | BAY-94-9343; BAY-94-9343-SPDB-DM4; Anti-mesothelin antibody-drug conjugate BAY 94-9343 | Phase 2 Clinical | Bayer AG, Morphosys Ag | Ovarian Neoplasms; Solid tumours; Cystadenocarcinoma, Serous; Neoplasms; Pancreatic Neoplasms; Mesothelioma; Peritoneal Neoplasms; Fallopian Tube Neoplasms; Lung Neoplasms; Carcinoma, Endometrioid | Details |
Gavocabtagene autoleucel | TC-210 | Phase 2 Clinical | Tcr2 Therapeutics Inc | Ovarian Neoplasms; Mesothelioma; Cholangiocarcinoma; Carcinoma, Non-Small-Cell Lung | Details |
LMB-100 | LMB-100; RG-7787; RO-6927005 | Phase 2 Clinical | F. Hoffmann-La Roche Ltd | Neoplasms, Mesothelial; Carcinoma; Small Cell Lung Carcinoma; Adenocarcinoma of Lung; Neoplasms; Pancreatic Neoplasms; Mesothelioma; Cholangiocarcinoma; Lung Neoplasms; Pleural Effusion, Malignant; Carcinoma, Non-Small-Cell Lung | Details |
anti-MESO CAR-T cells (Zhejiang University) | UCLM802; UCLM-802 | Phase 2 Clinical | Zhejiang University, Hrain Biotechnology Co Ltd | Ovarian Neoplasms; Solid tumours | Details |
Anti-CTLA-4 and PD-1 CAR-T cell therapy (Shanghai Cell Therapy Research Institute) | Phase 2 Clinical | Shanghai Cell Therapy Research Institute | Neoplasms | Details | |
HPN-536 | HPN-536 | Phase 2 Clinical | Harpoon Therapeutics | Neoplasms | Details |
Autologous PD-1 antibody expressing mesothelin-targeted CAR-Tcells therapy (Shanghai Cell Therapy Research Institute) | Phase 2 Clinical | Shanghai Cell Therapy Research Institute | Solid tumours | Details | |
CD40 ligand expressing MSLN-CAR T cells | Phase 2 Clinical | Pla General Hospital | Solid tumours | Details | |
A2B-694 | A2B-694; A2B694 | Phase 2 Clinical | A2 Biotherapeutics Inc | Solid tumours; Ovarian Neoplasms; Rectal Neoplasms; Carcinoma, Renal Cell; Small Cell Lung Carcinoma; Colonic Neoplasms; Pancreatic Neoplasms; Neoplasms; Mesothelioma; Colorectal Neoplasms; Lung Neoplasms; Carcinoma, Non-Small-Cell Lung | Details |
RNA-Meso-CIR-T | RNA-Meso-CIR-T | Phase 1 Clinical | Novartis Pharma Ag, University Of Pennsylvania | Mesothelioma | Details |
CART-meso | CART-meso | Phase 1 Clinical | Novartis Pharma Ag, University Of Pennsylvania | Ovarian Neoplasms; Carcinoma; Adenocarcinoma of Lung; Carcinoma, Ovarian Epithelial; Pancreatic Neoplasms; Mesothelioma; Breast Neoplasms; Fallopian Tube Neoplasms | Details |
ABBV-428 | ABBV-428; ABBV428 | Phase 1 Clinical | Abbvie Inc | Solid tumours | Details |
Anti-mesothelin thorium-227 labeled antibody chelator conjugate | BAY-2287411 | Phase 1 Clinical | Bayer AG | Ovarian Neoplasms; Mesothelioma; Carcinoma, Pancreatic Ductal | Details |
AB-1015 | AB-1015 | Phase 1 Clinical | Arsenal Biosciences Inc | Ovarian Neoplasms; Carcinoma, Ovarian Epithelial | Details |
SynKIR-110 | SynKIR™-110; SynKIR-meso | Phase 1 Clinical | Verismo Therapeutics Inc | Ovarian Neoplasms; Mesothelioma; Cholangiocarcinoma | Details |
KT-032 | KT-032 | Phase 1 Clinical | Nanjing Kati Medical Technology Co Ltd | Ovarian Neoplasms; Solid tumours; Pancreatic Neoplasms; Mesothelioma | Details |
JNJ-79032421 | JNJ-79032421; JNJ-2421 | Phase 1 Clinical | Janssen Research & Development Llc | Solid tumours | Details |
YL-215 | YL215; YL-215 | Phase 1 Clinical | MediLink Therapeutics Co Ltd | Solid tumours | Details |
GPC3/Mesothelin-CAR-γδT Cells therapy(Second Affiliated Hospital Of Guangzhou Medical University) | Phase 1 Clinical | Second Affiliated Hospital Of Guangzhou Medical University | Solid tumours; Liver Neoplasms; Small Cell Lung Carcinoma; Pancreatic Neoplasms; Mesothelioma; Lung Neoplasms | Details | |
AMG 305 | AMG-305; AMG 305 | Phase 1 Clinical | Amgen Inc | Solid tumours | Details |
UCMYM-802 | UCMYM802; UCMYM-802 | Phase 1 Clinical | Shanghai Youti zjisheng Biomedicine Co Ltd | Solid tumours; Ovarian Neoplasms; Rectal Neoplasms; Pancreatic Neoplasms; Mesothelioma; Breast Neoplasms; Colorectal Neoplasms; Bile Duct Neoplasms | Details |
HBM-9033 | HBM-9033; HBM9033 | Phase 1 Clinical | Nona Biosciences | Solid tumours | Details |
Anti-mesothelin CAR T cell therapy (UTC Therapeutics Inc) | Phase 1 Clinical | UTC Therapeutics Inc | Solid tumours | Details | |
LD013 CAR T-cell therapy (Nanjing Landun Biotechnology) | LD013; LD-013 | Phase 1 Clinical | Nanjing Landun Biotechnology Co Ltd | Ovarian Neoplasms; Solid tumours | Details |
RD-138 | RD-138 | Phase 1 Clinical | Nanjing Iaso Biotherapeutics Co Ltd | Multiple Myeloma | Details |
RD-133 | RD133 | Phase 1 Clinical | Nanjing Iaso Biotherapeutics Co Ltd | Solid tumours; Neoplasms | Details |
PM-3006 | PM-3006 | Phase 1 Clinical | Biotheus Inc | Details | |
Autologous Mesothelin-specific TCR-T Cell Therapy (Lonza Walkersville) | Phase 1 Clinical | Fred Hutchinson Cancer Research Center | Pancreatic Neoplasms; Carcinoma, Pancreatic Ductal | Details | |
Anti-mesothelin CAR-NK cell therapy(Guojianchengnuo) | ALF-101 | Phase 1 Clinical | Guojianchengnuo Biotechnology (Beijing) Co Ltd | Carcinoma, Ovarian Epithelial | Details |
Inezetamab | AMG-994 | Phase 1 Clinical | Amgen Inc | Solid tumours | Details |
αPD1-MSLN-CAR T cell therapy (Shanghai Cell Therapy Group Co.,Ltd) | BZDS1901; BZDS-1901; BZD1901 | Phase 1 Clinical | Shanghai Cell Therapy Group Co Ltd | Ovarian Neoplasms; Solid tumours; Mesothelioma; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung | Details |
KD-021 | KD-021 | Phase 1 Clinical | Nanjing Kaedi Biotechnology Co Ltd | Neoplasms | Details |
Anti-mesothelin CAR-T (Pregene) | Clinical | Pregene (Shenzhen) Biotechnology Co Ltd | Hydrothorax | Details | |
TCR-like CAR-T Cell Therapy(Zhongda Hospital Southeast University) | Zhongda Hospital Southeast University | Details | |||
Mesothelin-CAR-T Cells(Fapon Biopharma) | FP-002 | Fapon Biotech Inc | Details |
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