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Human MAOA Protein, His Tag, low endotoxin (active enzyme)

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Cat. No. / Size
Price
Qty
MAA-H5547-20ug
$245.00
MAA-H5547-100ug
$780.00
MAA-H5547-500ug
$2225.00
ETA of in-stock products:2 business days
Sub-Total$ 0

Product Details

  • Synonyms

    MAOA

  • Source

    Human MAOA, His Tag (MAA-H5547) is expressed from Baculovirus-Insect cells. It contains AA Glu 2 - Ser 527 (Accession # P21397-1).

    Predicted N-terminus: Met

    Request for sequence
  • Molecular Characterization

    MAOA Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the N-terminus.

    The protein has a calculated MW of 61.6 kDa. The protein migrates as 60 kDa under reducing (R) condition (SDS-PAGE).

  • Endotoxin

    Less than 0.01 EU per μg by the LAL method / rFC method.

  • Purity

    >95% as determined by SDS-PAGE.

  • Formulation

    This product is not suitable for cell based experiments due to cytotoxicity of DDM.
    DDM and CHS are INDISPENSABLE to keep membrane protein soluble and active, under no circumstances should you remove DDM and CHS.
    DDM/CHS buffer (DC-11) is sold separately and not included in protein, and please contact us if you need the buffer.
    If glycerol is not compatible with your application, remove glycerol just before the immediate experiment, and NEVER store glycerol-free protein solution.

    Supplied as 0.2 μm filtered solution in 50 mM HEPES, 150 mM NaCl, DDM, CHS, pH7.5 with glycerol as protectant.

    Contact us for customized product form or formulation.

  • Shipping

    This product is supplied and shipped with dry ice, please inquire the shipping cost.

  • Storage

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. The product MUST be stored at -70°C or lower upon receipt;
    2. -70°C for 3 months under sterile conditions.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process
  • *The DDM/CHS buffer (Cat. No. DC-11) is sold separately and not included in protein, you can follow the link for product information.

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Performance Data

  • SDS-PAGE

    MAOA SDS-PAGE

    Human MAOA, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

  • Bioactivity

    Measured by its ability to produce hydrogen peroxide during the oxidation of Tyramine. The specific activity is >300 pmol/min/ug, as measured under the described conditions (QC tested).

    Protocol

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Background

MAOA, Monoamine oxidase-A is an FAD-dependent mitochondrial enzyme, which, together with its isoenzyme MAO-B, catalyses the oxidative deamination of structurally diverse amines. MAOA is mainly involved in the metabolism of monoamine neurotransmitters, such as such as serotonin, dopamine, and norepinephrine. Inhibitors of MAOA are in clinical use for affective disorders and is approved to treat despression.

Recent Advances

 
Drug Development Progress
  • English Name:

    Monoamine oxidase A

  • Category:

  • Approved Drugs:

    2 Details

  • Drugs in Clinical Trials:

    1 Details

  • Highest Development Stage:

    Approved

Drug Candidate Licensing
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  • Background