Human IL-3 R alpha / CD123 Protein, His Tag, low endotoxin (MALS & SPR verified)

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Cat. No. / Size
Price
Qty
ILA-H52H6-100ug
$360.00
ILA-H52H6-1mg (500ug X 2)
$2615.00
ETA of in-stock products:2 business days

Product Details

  • Synonyms

    IL3R, IL3RA, IL-3Ra, IL-3R-alpha, IL3RAY, IL3RX, IL3RY, CD123 antigen, CD123, hIL3Ra, hIL-3Ra, MGC34174, IL-3 R alpha

  • Source

    Human IL-3 R alpha, His Tag (ILA-H52H6) is expressed from human 293 cells (HEK293). It contains AA Thr 19 - Arg 305 (Accession # P26951-1).

    Predicted N-terminus: Thr 19

    Request for sequence
  • Molecular Characterization

    IL-3 R alpha Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 35.0 kDa. The protein migrates as 45-65 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 0.01 EU per μg by the LAL method / rFC method.

  • Purity

    >95% as determined by SDS-PAGE.

    >95% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • SDS-PAGE

    IL-3 R alpha SDS-PAGE

    Human IL-3 R alpha, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    IL-3 R alpha SEC-MALS

    The purity of Human IL-3 R alpha, His Tag (Cat. No. ILA-H52H6) is more than 95% and the molecular weight of this protein is around 47-57 kDa verified by SEC-MALS.

    Report
  • Bioactivity-SPR

     IL-3 R alpha SPR

    Human IL-3 R alpha, His Tag (Cat. No. ILA-H52H6) captured on CM5 Chip via anti-His antibody can bind Human IL-3, Tag Free with an affinity constant of 0.253 μM as determined in SPR assay (Biacore T200) (QC tested).

    Protocol

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  • A***r2026-03-11
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    We've always had a pleasure experience with AcroBio. Products are always top quality, quote requests come back super quick, and everyone is very kind. Great, great team to work with!

Background

Interleukin 3 receptor alpha (low affinity) (IL3RA), also known as CD123 (Cluster of Differentiation 123) is a 70-kD glycoprotein member of the hematopoietin receptor superfamily. This protein associates with a beta subunit common to the receptors for IL-5 and granulocyte-macrophage colony-stimulating factor (GM-CSF) to form a high-affinity receptor for IL-3. The interleukin-3 receptor α chain (CD123) has been identified as a potential immunotherapeutic target because it is overexpressed in AML compared with normal hematopoietic stem cells.

Recent Advances

 
Drug Development Progress
  • English Name:

    Interleukin-3 receptor subunit alpha

  • Category:

  • Approved Drugs:

    1 Details

  • Drugs in Clinical Trials:

    40 Details

  • Highest Development Stage:

    Approved

Drug Candidate Licensing
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