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Product Details
Synonyms
IFNAR1, IFNAR, CRF2-1, IFN-R-1, IFNAR-1
Source
Cynomolgus IFN-alpha/beta R1 Protein, His Tag (IF1-C52H3) is expressed from human 293 cells (HEK293). It contains AA Ala 25 - Lys 437 (Accession # A0A7N9D7J0-1).
Predicted N-terminus: Ala 25
Request for sequenceMolecular Characterization
Other Tags and Version Biotin & Other Labeled Version
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 49.3 kDa. The protein migrates as 65-95 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin
Less than 1.0 EU per μg by the LAL method / rFC method.
Purity
>90% as determined by SDS-PAGE.
Formulation
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
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Reconstitution
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Storage
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
- -20°C to -70°C for 12 months in lyophilized state;
- -70°C for 3 months under sterile conditions after reconstitution.
ACRO Quality Management System
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Performance Data
SDS-PAGE
Cynomolgus IFN-alpha/beta R1 Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).
SEC-MALS
The purity of Cynomolgus IFN-alpha/beta R1 Protein, His Tag (Cat. No. IF1-C52H3) is more than 85% and the molecular weight of this protein is around 65-85 kDa verified by SEC-MALS.
Report
Bioactivity-ELISA
Immobilized Human IFN-alpha 1, Fc Tag (Cat. No. IFA-H5258) at 5 μg/mL (100 μL/well) can bind Cynomolgus IFN-alpha/beta R1 Protein, His Tag (Cat. No. IF1-C52H3) with a linear range of 5-78 ng/mL (QC tested).
Protocol
Bioactivity-BLI
Loaded bind Human IFN-alpha 1, Fc Tag (Cat. No. IFA-H5258) on Protein A Biosensor, can bind Cynomolgus IFN-alpha/beta R1 Protein, His Tag (Cat. No. IF1-C52H3) with an affinity constant of 16.5 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).
Protocol
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Background
Recent Advances
Drug Development Progress- English Name：
Interferon-alpha/beta receptor alpha chain
- Category：
- Approved Drugs：
5 Details
- Drugs in Clinical Trials：
0 Details
- Highest Development Stage：
Approved
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