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Human CD3 delta Protein, His Tag, low endotoxin

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Cat. No. / Size
Price
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CDD-H5224-100ug
$325.00
CDD-H5224-1mg
$2000.00
ETA of in-stock products:2 business days
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Product Details

  • Synonyms

    CD3D, CD3-DELTA, T3D

  • Source

    Human CD3 delta, His Tag (CDD-H5224) is expressed from human 293 cells (HEK293). It contains AA Phe 22 - Ala 105 (Accession # P04234-1).

    Predicted N-terminus: Phe 22

    Request for sequence
  • Molecular Characterization

    CD3 delta Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 11.4 kDa. The protein migrates as 18-28 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 0.01 EU per μg by the LAL method / rFC method.

  • Purity

    >90% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Shipping and Storage

    This product is shipped at ambient temperature.

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • SDS-PAGE

    CD3 delta SDS-PAGE

    Human CD3 delta, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

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Background

T-cell surface glycoprotein CD3 delta, also known as CD3D. CD3D, together with CD3- epsilon(CD3E) , CD3-gamma and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. T cell receptor-CD3 complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways.When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z.

Recent Advances

 
Drug Development Progress
  • English Name:

    T cell surface glycoprotein CD3

  • Category:

  • Approved Drugs:

    10 Details

  • Drugs in Clinical Trials:

    198 Details

  • Highest Development Stage:

    Approved

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