Monoclonal Anti-RSV(B)-Pre-F0 Antibody, Mouse IgG1 (7B2) (MALS verified)

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Cat. No. / Size
Price
Qty
RSV-MY2189-100ug
$425.00
RSV-MY2189-1mg (500ug X 2)
$2790.00
ETA of in-stock products:2 business days

Product Details

  • Source

    Monoclonal Anti-RSV(B)-Pre-F0 Antibody, Mouse IgG1 (7B2) is a mouse monoclonal antibody recombinantly expressed in HEK293 cells.

  • Antibody Type

    Recombinant Monoclonal

  • Clone

    7B2

  • Isotype

    Mouse IgG1, Kappa

  • Host Species

    Mouse

  • Reactivity

    Virus

  • Immunogen

    Recombinant HRSV (B) Pre-fusion glycoprotein F0 is expressed from human 293 cells

  • Specificity

    Specifically recognizes HRSV (B) Pre-fusion glycoprotein F0.

  • Cross Verification

    This product No cross-reactivity in ELISA with
    HRSV (A) Pre-fusion glycoprotein F0, His Tag (Cat. No. RSF-V52H7).
    HRSV (A) Post-fusion glycoprotein F0, His Tag (Cat. No. RSF-V52H6).
    HRSV (B) Post-fusion glycoprotein F0, His Tag (Cat. No. RSF-V52H9).

  • Purification

    Protein A purified / Protein G purified.

  • Aggregation

    Less than 10%, as determined by SEC-MALS.

  • Concentration

    Please refer to the Certificate of Analysis (CoA).

  • Form

    Lyophilized

  • Formulation

    Lyophilized from a 0.22 μm-filtered solution in PBS (pH 7.4), with trehalose as protectant.

    Please contact us for customized product forms or formulations.

  • Reconstitution

    Please refer to the Certificate of Analysis (CoA) for specific instructions.

  • Shipping

    Lyophilized product is shipped at ambient temperature.

  • Storage

    For long term storage, the product should be stored in a lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • Notices

    Product Specific Notices: For research use only.

  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • Bioactivity-ELISA

     RSV(B)-Pre-F0 ELISA

    Immobilized HRSV (B) Pre-fusion glycoprotein F0, His Tag (Cat. No. RSF-V52H8) at 1 μg/mL (100 μL/well) can bind Monoclonal Anti-RSV(B)-Pre-F0 Antibody, Mouse IgG1 (7B2) (Cat. No. RSV-MY2189) with a linear range of 0.5-63 ng/mL (QC tested).

    Protocol

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FAQ

  • Product

    What do “pre” and “post” refer to in the names of viral proteins?

    In virology, “pre” refers to the conformation of a viral surface glycoprotein before fusion with the host cell membrane, while “post” refers to the conformation after membrane fusion and entry into the host cell. Both are naturally occurring states in the viral life cycle. Because the “pre” conformation represents a critical stage before viral entry, antibodies designed against this state often exhibit stronger neutralizing activity and are therefore more effective in preventing infection.

Background

Human respiratory syncytial virus (HRSV) is the most common etiological agent of acute lower respiratory tract disease in infants and can cause repeated infections throughout life. The RSV fusion glycoprotein (RSV F) is the principal target of RSV neutralizing antibodies in human sera. The RSV F is a type I viral fusion protein synthesized as inactive, single-chain polypeptides that assemble into trimers. RSV F fuses the viral and host cell membranes by irreversible protein refolding from the labile prefusion conformation to the stable post-fusion conformation.

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