Angiogenin Overview
Molecule Name
Angiogenin
Synonyms
ALS9,ANG,Angiogenin,angiogenin, ribonuclease, RNase A family, 5,EC 3.1.27,EC:3.1.27.-
Drug Development Progress
Drugs in Clinical Trials0
Approved Drugs0
Highest Development StagePreclinical
Target Synonym
Ribonuclease 5，RNASE5，RAA1，Homo Sapiens Epididymis Luminal Protein 168，Angiogenin， Ribonuclease， RNase A Family， 5，Ribonuclease A Family Member 5，RNase 5，HEL168，Epididymis Luminal Protein 168
Background
Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs). Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo
Angiogenin Product List
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