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TIM-4

TIM-4 Overview

English Name	T-cell immunoglobulin and mucin domain-containing protein 4	Approved Drugs	0
Drugs in Clinical Trials	1	Target Synonym	T-cell immunoglobulin mucin receptor 4 (TIM-4)，T-cell membrane protein 4，TIM4
Highest Development Stage	Phase 1 Clinical

English Name	T-cell immunoglobulin and mucin domain-containing protein 4
Target Synonym	T-cell immunoglobulin mucin receptor 4 (TIM-4)，T-cell membrane protein 4，TIM4
Approved Drugs	0
Drugs in Clinical Trials	1
Highest Development Stage	Phase 1 Clinical

TIM-4 Product List

Product Category
Protein (1)
Product Status
Launched (1)
Species
Human (1)
Tag
His Tag (1)
Conjugate
Unconjugated (1)

Cat. No.	Species	Host	Product Description	Structure	Purity	Feature
TI4-H52H3	Human	HEK293	Human TIM-4 / TIMD4 Protein, His Tag

Total: 1

TIM-4 Background

The T cell immunoglobulin mucin (TIM) proteins regulate T cell activation and tolerance. An essential step during clearance of apoptotic cells is the recognition of phosphatidylserine (PS) exposed on apoptotic cells by its receptors on phagocytes. The phosphatidylserine (PS) receptor Tim-4 mediates phagocytosis of apoptotic cells by binding to PS exposed on the surface of these cells, and thus functions as a PS receptor for apoptotic cells. Tim-4 directly binding to PS and functioning as a tethering receptor for phagocytosis of apoptotic cells has been extensively studied over the past decade. However, the molecular mechanisms by which Tim-4 collaborates with other engulfment receptors during efferocytosis remain elusive.

TIM-4 Synonyms

TIM4,TIMD4,SMUCKLER

Clinical Drug Information

English Name	Research Code	Highest Development Stage	Company	Indication	Clinical Trial
LPX-TI641	LPX-TI-641	Phase 1 Clinical	LAPIX Therapeutics Inc	Arthritis, Psoriatic; Arthritis, Rheumatoid; Autoimmune Diseases; Demyelinating Diseases; Dermatitis, Atopic; Multiple Sclerosis; Neuromyelitis Optica; Psoriasis	Details