TFPI-2

TFPI-2 Overview

English Name	DNA-(apurinic or apyrimidinic site) lyase	Approved Drugs	0
Drugs in Clinical Trials	1	Target Synonym	AP endonuclease 1，DNA-(apurinic or apyrimidinic site) lyase，APE1，APEN，REF-1，Apurinic-apyrimidinic endonuclease 1，APEX nuclease，REF1，APEX，APEX1，Apurinic/Apyrimidinic Endodeoxyribonuclease 1，APEX Nuclease (Multifunctional DNA Repair Enzyme) 1，Redox Factor-1，HAP1，APE，APX，APEX Nuclease (Multifunctional DNA Repair Enzyme)，Deoxyribonuclease (Apurinic Or Apyrimidinic)，Apurinic/Apyrimidinic (Abasic) Endonuclease，AP Endonuclease Class I，Protein REF-1，AP Lyase，APE-1，DNA-(apurinic or apyrimidinic site) endonuclease
Highest Development Stage	Phase 2 Clinical

English Name	DNA-(apurinic or apyrimidinic site) lyase
Target Synonym	AP endonuclease 1，DNA-(apurinic or apyrimidinic site) lyase，APE1，APEN，REF-1，Apurinic-apyrimidinic endonuclease 1，APEX nuclease，REF1，APEX，APEX1，Apurinic/Apyrimidinic Endodeoxyribonuclease 1，APEX Nuclease (Multifunctional DNA Repair Enzyme) 1，Redox Factor-1，HAP1，APE，APX，APEX Nuclease (Multifunctional DNA Repair Enzyme)，Deoxyribonuclease (Apurinic Or Apyrimidinic)，Apurinic/Apyrimidinic (Abasic) Endonuclease，AP Endonuclease Class I，Protein REF-1，AP Lyase，APE-1，DNA-(apurinic or apyrimidinic site) endonuclease
Approved Drugs	0
Drugs in Clinical Trials	1
Highest Development Stage	Phase 2 Clinical

TFPI-2 Product List

Product Category
Protein (1)
Product Status
Launched (1)
Species
Human (1)
Tag
His Tag (1)
Conjugate
Unconjugated (1)

Cat. No.	Species	Host	Product Description	Structure	Purity	Feature	Order Now
TF2-H5227	Human	HEK293	Human TFPI-2 Protein, His Tag				Add to Cart

Total: 1

TFPI-2 Background

Tissue Factor Pathway Inhibitor 2 (TFPI2) is also known as placental protein 5 (PP5) and retinal pigment epithelial cell factor 1 (REF1), is a member of the Kunitz-type serine proteinase inhibitor family, is a structural homologue of tissue factor pathway inhibitor (TFPI). TFPI2 is highly abundant in the full-term placenta and widely expressed in umbilical vein endothelial cells, liver, placenta, heart, pancreas, and maternal serum at advanced pregnancy. TFPI2 may play a role in the regulation of plasmin-mediated matrix remodeling. Inhibits trypsin, plasmin, factor VIIa/tissue factor and weakly factor Xa and has no effect on thrombin. Reduced synthesis of TFPI-2 has been related to numerous pathophysiological processes such as inflammation, angiogenesis, atherosclerosis, retinal degeneration and tumor growth / metastasis.

TFPI-2 Synonyms

TFPI2,PP5,REF1

Clinical Drug Information

English Name	Research Code	Highest Development Stage	Company	Indication	Clinical Trial
APX-3330	APX-3330; APX3330; E-3330	Phase 2 Clinical	Eisai Co Ltd	Solid tumours; Inflammatory Bowel Diseases; Neoplasms; Diabetic macular oedema; Diabetic Retinopathy	Details