SMAC

SMAC Overview

English Name	Diablo homolog, mitochondrial	Approved Drugs	0
Drugs in Clinical Trials	1	Target Synonym	Direct IAP-binding protein with low pI，Second mitochondria-derived activator of caspase，Smac，Diablo IAP-Binding Mitochondrial Protein
Highest Development Stage	Phase 1 Clinical

English Name	Diablo homolog, mitochondrial
Target Synonym	Direct IAP-binding protein with low pI，Second mitochondria-derived activator of caspase，Smac，Diablo IAP-Binding Mitochondrial Protein
Approved Drugs	0
Drugs in Clinical Trials	1
Highest Development Stage	Phase 1 Clinical

SMAC Product List

Product Category
Protein (1)
Product Status
Launched (1)
Species
Human (1)
Tag
His Tag (1)
Conjugate
Unconjugated (1)

Cat. No.	Species	Host	Product Description	Structure	Purity	Feature	Order Now
DIO-H5129	Human	E. coli	Human SMAC / Diablo Protein, His Tag				Add to Cart

Total: 1

SMAC Background

Diablo homolog, mitochondrial (DIABLO) is also known as direct IAP-binding protein with low pI and second mitochondria-derived activator of caspase (SMAC), which can interact with BIRC2/c-IAP1, BIRC3/c-IAP2, XIAP/BIRC4, BIRC6/bruce and BIRC7/livin. Acting by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP),DIABLO can also promote apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Also, DIABLO inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Furthermore, DIABLO is defective in the capacity to down-regulate the XIAP/BIRC4 abundance.