Siglec-15

Siglec-15 Overview

English Name	Sialic acid-binding Ig-like lectin 15	Approved Drugs	0
Drugs in Clinical Trials	3	Target Synonym	SIGLEC15，Sialic Acid Binding Ig Like Lectin 15，CD33 Antigen-Like 3，CD33L3，Sialic Acid-Binding Ig-Like Lectin 15，SIGLEC-15，HsT1361，CD33 Molecule-Like 3，Sialic Acid Binding Ig-Like Lectin 15
Highest Development Stage	Phase 2 Clinical

English Name	Sialic acid-binding Ig-like lectin 15
Target Synonym	SIGLEC15，Sialic Acid Binding Ig Like Lectin 15，CD33 Antigen-Like 3，CD33L3，Sialic Acid-Binding Ig-Like Lectin 15，SIGLEC-15，HsT1361，CD33 Molecule-Like 3，Sialic Acid Binding Ig-Like Lectin 15
Approved Drugs	0
Drugs in Clinical Trials	3
Highest Development Stage	Phase 2 Clinical

Siglec-15 Product List

Product Category
Protein (7)
Product Status
Launched (7)
Species
Human (4)Rhesus macaque (1)Mouse (1)Rat (1)
Tag
Fc Tag (1)His Tag (4)His Tag & Avi Tag (1)Fc Tag & Avi Tag (1)
Conjugate
Unconjugated (5)Biotin-labeled (2)

Cat. No.	Species	Host	Product Description	Order Now
HOT SG5-H5253	Human	HEK293	Human Siglec-15 / CD33L3 Protein, Fc Tag	Add to Cart
HOT SG5-H52H3	Human	HEK293	Human Siglec-15 / CD33L3 Protein, His Tag, low endotoxin (MALS verified)	Add to Cart
HOT SG5-H82E9	Human	HEK293	Biotinylated Human Siglec-15 / CD33L3 Protein, His,Avitag™ (recommended for biopanning)	Add to Cart
HOT SG5-H82F5	Human	HEK293	Biotinylated Human Siglec-15 / CD33L3 Protein, Fc,Avitag™	Add to Cart
SG5-M52H7	Mouse	HEK293	Mouse Siglec-15 / CD33L3 Protein, His Tag	Add to Cart
SG5-C52H6	Rhesus macaque	HEK293	Rhesus macaque Siglec-15 / CD33L3 Protein, His Tag	Add to Cart
SG5-R52H3	Rat	HEK293	Rat Siglec-15 / CD33L3 Protein, His Tag (MALS verified)	Add to Cart

Total: 7

Siglec-15 Background

Siglec-15 is a DAP12-associated immunoreceptor, which belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. Siglecs are cell surface proteins that bind sialic acid. They are found primarily on the surface of immune cells and are a subset of the I-type lectins. Siglec-15 consisting of immunoglobulin (Ig)-like domains, transmembrane domain and a short cytoplasmic tail. Siglec-15 is that recognizes sialylated glycans and regulates osteoclast differentiation. Siglec-15 is a potential therapeutic target for osteoporosis and plays a conserved regulatory role in the immune system of vertebrates.

Siglec-15 Synonyms

CD33 antigen-like 3,SIGLEC-15,CD33L3,sialic acid-binding Ig-like lectin 15,Siglec15,Siglec-15

Clinical Drug Information

English Name	Research Code	Highest Development Stage	Company	Indication	Clinical Trial
NC-318	NC-318; 5G-12	Phase 2 Clinical	Yale School Of Medicine	Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Cholangiocarcinoma; Endometrial Neoplasms; Lung Neoplasms; Melanoma; Solid tumours; Squamous Cell Carcinoma of Head and Neck	Details
DS-1501	DS-1501	Phase 1 Clinical	Daiichi Sankyo Co Ltd	Osteoporosis	Details
BSI-060T	PYX-106; BSI-060T	Phase 1 Clinical	Biosion Inc	Neoplasm Metastasis; Solid tumours	Details

Product Reviews

1***22019-10-11
6People Like
Human Siglec-15 / CD33L3 Protein, His Tag, low endotoxin (MALS verified)
Siglec-15 is a relatively new type of immune checkpoint molecule. In the process of antibody molecule screening, we used ACRO's Siglec-15 antigen. It has shown very good stability in protein-level binding experiments, and the bioactivity was also quite good which was verified in functional experiments.
1***32019-10-11
1People Like
Human Siglec-15 / CD33L3 Protein, His Tag, low endotoxin (MALS verified)
The product is pretty good and the price is competitive. Besides, the delivery was fast. In particular, there is a literature introduction cited the product. It is obvious that each target has been carefully studied.
1***22019-10-12
8People Like
Human Siglec-15 / CD33L3 Protein, Fc Tag
We can obtain a good inhibitory effect using this protein to verify its inhibitory on T-cells functions. S15-hFc protein can effectively inhibit the secretion of IFN-gamma stimulated by OKT3 in CD4 + T cells.