ROR1

ROR1

ROR1 Overview

Molecule Name
Inactive tyrosine-protein kinase transmembrane receptor ROR1
Synonyms
ROR1,NTRKR1
Drug Development Progress
Drugs in Clinical Trials23
Approved Drugs0
Highest Development StagePhase 3 Clinical
Target Synonym
EC 2.7.10.1,Inactive tyrosine-protein kinase transmembrane receptor ROR1,NTRKR1,ROR1,Receptor Tyrosine Kinase Like Orphan Receptor 1,Neurotrophic Tyrosine Kinase, Receptor-Related 1,DJ537F10.1,ROR-1

ROR1 Product List

Species
  • Human / Cynomolgus / Rhesus macaque(10)
  • Human(6)
  • Mouse(4)
  • Canine(1)
  • Rat(1)
Tag
  • His Tag(13)
  • Fc Tag(3)
  • Fc Tag & Avi Tag(2)
  • His Tag & Avi Tag(2)
  • Avi Tag(1)
  • Mouse IgG Fc Tag(1)
Host
  • HEK293(22)
Conjugate
  • Unconjugated(12)
  • Biotin-labeled(5)
  • FITC Labeled(2)
  • PE Labeled(2)
  • APC Labeled(1)
Grade
  • RUO(22)
Low Endotoxin
  • Yes(1)
  • No(21)
MoleculeCat. No.Product NameSpeciesHostStructurePurityActivitySize&Price
ROR1
Human / Cynomolgus / Rhesus macaque ROR1 Protein, His Tag
Human / Cynomolgus / Rhesus macaque
HEK293
HPLCSDS-PAGE
SPR

$1350.00

250ug
ROR1
Human / Cynomolgus / Rhesus macaque ROR1 Protein, His Tag, low endotoxin (Mass Spec & MALS verified)
Human / Cynomolgus / Rhesus macaque
HEK293
MALSSDS-PAGE
ELISASPRBLIFlow

$470.00

100ug
ROR1
APC-Labeled Human ROR1 Protein, His TagStar Staining
Human
HEK293
Flow

$360.00

25tests
ROR1
PE-Labeled Human ROR1 Protein, His Tag (Site-specific conjugation)
Human
HEK293
Flow

$360.00

25tests
ROR1
Human / Cynomolgus / Rhesus macaque ROR1 (308-395, Kringle domain) Protein, His Tag (MALS verified)
Human / Cynomolgus / Rhesus macaque
HEK293
MALSSDS-PAGE

$420.00

50ug
ROR1
HOTAvitag
RO1-H82E6
Biotinylated Human / Cynomolgus / Rhesus macaque ROR1 Protein, His,Avitag™ (MALS verified)
Human / Cynomolgus / Rhesus macaque
HEK293
MALSSDS-PAGE
ELISASPRBLIFlow

$470.00

25ug
ROR1
Canine ROR1 Protein, His Tag (MALS verified)
Canine
HEK293
MALSSDS-PAGE

$360.00

100ug
ROR1
Human / Cynomolgus / Rhesus macaque ROR1 (39-151, Ig-like domain) Protein, His Tag (MALS verified)
Human / Cynomolgus / Rhesus macaque
HEK293
MALSSDS-PAGE
ELISAFlow

$380.00

50ug
ROR1
Human / Cynomolgus / Rhesus macaque ROR1 (165-305, Frizzled domain) Protein, His Tag (MALS verified)
Human / Cynomolgus / Rhesus macaque
HEK293
MALSSDS-PAGE

$380.00

50ug
ROR1
Human / Cynomolgus / Rhesus macaque ROR1 Protein, Fc Tag (MALS verified)
Human / Cynomolgus / Rhesus macaque
HEK293
MALSSDS-PAGE
ELISABLI

$260.00

200ug
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FAQ

Which ROR1 species are available for cross-reactivity studies?

ACROBiosystems offers ROR1 proteins from human, cynomolgus monkey, rhesus macaque, mouse, and canine in selected formats. Species availability and construct design vary by product. Confirm antibody cross-reactivity with the specific protein and match the species to your intended experimental model.

During ELISA screening of human or humanized anti-ROR1 antibodies, how can background from a human Fc-tagged antigen be reduced?

ACROBiosystems offers ROR1 proteins with mouse IgG2a Fc, His, and biotinylated AviTag™ formats. The mouse IgG2a Fc format separates the antigen tag from anti-human Fc detection, while the His-tagged and His-AviTag™ formats avoid an Fc tag altogether, reducing tag-related detection background.

For benchmarking Zilovertamab (UC-961)-derived ROR1 therapeutics, what validated recombinant ROR1 options are available?

ACROBiosystems’ full-length ROR1 ECD proteins have direct Zilovertamab binding validation. The His-tagged format is validated by ELISA, SPR, and BLI, while the biotinylated His-AviTag™ format has SPR and BLI data. The isolated Kringle domain is available for epitope studies but does not currently have published Zilovertamab validation.

After ROR1-binding clones have been identified, how can recombinant ROR1 domain proteins support epitope mapping?

ACROBiosystems provides the full ROR1 ECD together with separate Ig-like, Frizzled, and Kringle domain proteins. This matched panel supports domain-level assignment of antibody-binding regions but does not provide residue-level epitope resolution.

How can labeled ROR1 proteins be used to evaluate ROR1 CAR binding?

Fluorescently labeled ROR1 proteins can be used to assess binding to ROR1-specific CARs by flow cytometry. For example, APC-Labeled Human ROR1 Protein (RO1-HA2H4) has documented binding data with anti-ROR1 CAR-293 cells. Include non-transfected cells and an appropriate negative control to assess binding specificity.
Asset Licensing Opportunity

Antibody Project Trading Platform

Project NameProject StageMolecule TypeMolecule SourceDisease AreaIndication
ROR1 mAb - 01LeadMonoclonalFull HumanHematological Malignancy,AutoImmunitySolid tumor,Blood tumor
Project Name
ROR1 mAb - 01
Project Stage
Lead
Molecule Type
Monoclonal
Molecule Source
Full Human
Disease Area
Hematological Malignancy,AutoImmunity
Indication
Solid tumor,Blood tumor
Resources

Clinical Drug Information

English NameResearch CodeHighest Development StageCompanyIndicationClinical Trial
Zilovertamab vedotinMK-2140; VLS-101Phase 3 ClinicalVelosbio Inc
Breast Neoplasms; Burkitt Lymphoma; Carcinoma, Non-Small-Cell Lung; Carcinoma, Transitional Cell; Hematologic Neoplasms; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myeloid, Acute; Lymphoma, B-Cell; Lymphoma, B-Cell, Marginal Zone; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Mantle-Cell; Lymphoma, T-Cell; Neoplasms; Neuroblastoma; Ovarian Neoplasms; Pancreatic Neoplasms; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Richter's Syndrome; Sarcoma, Ewing; Stomach Neoplasms; Triple Negative Breast Neoplasms; Waldenstrom Macroglobulinemia
Details
B-013B-013; B013Phase 3 ClinicalShanghai Crosslink Pharmaceutical R & D Co Ltd
Fallopian Tube Neoplasms; Ovarian Neoplasms; Peritoneal Neoplasms; Triple Negative Breast Neoplasms
Details
ZilovertamabUC-961Phase 2 ClinicalUniversity Of California San Diego
Breast Neoplasms; Immune System Diseases; Immunoproliferative Disorders; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphatic Diseases; Lymphoma; Lymphoma, B-Cell; Lymphoma, B-Cell, Marginal Zone; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Lymphoproliferative Disorders; Prostatic Neoplasms, Castration-Resistant
Details
EMB-07EMB-07Phase 2 ClinicalShanghai Epimab Biotherapeutics, Inc
Adenocarcinoma of Lung; Colorectal Neoplasms; Lymphoma; Lymphoma, B-Cell; Lymphoma, Non-Hodgkin; Ovarian Neoplasms; Pancreatic Neoplasms; Prostatic Neoplasms; Solid tumours; Stomach Neoplasms; Triple Negative Breast Neoplasms; Urinary Bladder Neoplasms; Uterine Neoplasms
Details
EB-DT-CAR-NKEB-DT-CAR-NKPhase 2 ClinicalBeijing Biotech
Breast Neoplasms; Triple Negative Breast Neoplasms
Details
NVG-222NVG-222Phase 2 ClinicalNovalGen Ltd
Hematologic Neoplasms; Neoplasms
Details
HDM-2005HDM2005; HDM-2005Phase 2 ClinicalHangzhou Zhongmei Huadong Pharmaceutical Co Ltd
Hematologic Neoplasms; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Mantle-Cell; Neoplasms; Solid tumours
Details
NebratamigGNC-035Phase 2 ClinicalSichuan Baili Pharmaceutical Co Ltd
Breast Neoplasms; Hematologic Neoplasms; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, Non-Hodgkin; Metastatic breast cancer; Solid tumours
Details
HG-030HG-030Phase 1 ClinicalHitgen Inc
Solid tumours
Details
anti-ROR1 CAR T-cell therapy (Fred Hutchinson Cancer Research Center/NCI)Phase 1 ClinicalNational Cancer Institute
Neoplasms
Details
PB-004PB004; PBA-0405; PB004 PureBIKE; PB-004Phase 1 ClinicalPure Biologics SA
Sarcoma; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Triple Negative Breast Neoplasms
Details
PRGN-3007PRGN-3007Phase 1 ClinicalPrecigen Inc
Hematologic Neoplasms; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Mantle-Cell; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Solid tumours; Triple Negative Breast Neoplasms
Details
RD-14RD-14; RD-14-01; CTE001; RD14-01Phase 1 ClinicalNanjing Bioheng Biotech Co Ltd
Breast Neoplasms; Lymphoma, Non-Hodgkin; Ovarian Neoplasms
Details
NEOK-001NEOK001; NEOK-001; ABL206; ABL-206Phase 1 ClinicalAbl Bio Inc
Solid tumours
Details
BR-111BR-111Phase 1 ClinicalZhejiang BioRay Biopharmaceuticals Co Ltd
Neoplasms
Details
SYS-6005RB-164; RB164; SYS6005Y; SYS-6005Phase 1 ClinicalCSPC Pharmaceutical Group Ltd
Hematologic Neoplasms; Leukemia, B-Cell; Lymphoma, B-Cell; Neoplasms; Solid tumours
Details
TQB-2101TQB2101; TQB-2101Phase 1 ClinicalNanjing Shunxin Pharmaceuticals Co Ltd Of Chiatai Tianqing Pharmaceutical Group
Breast Neoplasms; Colorectal Neoplasms; Hematologic Neoplasms; Lung Neoplasms; Neoplasms
Details
ZPC-21ZPC-21; IM-1021Phase 1 ClinicalZentalis Pharmaceuticals Inc
Hematologic Neoplasms; Neoplasms; Solid tumours
Details
BR-111ABR-111A; BR111A; BR-111-APhase 1 ClinicalZhejiang BioRay Biopharmaceuticals Co Ltd
Hematologic Diseases; Neoplasms; Solid tumours
Details
LYL-797LYL-797Phase 1 ClinicalLyell Immunopharma Inc
Carcinoma, Non-Small-Cell Lung; Solid tumours; Triple Negative Breast Neoplasms
Details
NVG-111NVG-111Phase 1 ClinicalNovalGen Ltd
Carcinoma, Non-Small-Cell Lung; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Mantle-Cell; Melanoma
Details
LCB-71CS-5001; LCB-71; ABL-202; ROR1-pPBDPhase 1 ClinicalAbl Bio Inc, Legochem Biosciences Inc
Hematologic Neoplasms; Lymphoma; Lymphoma, B-Cell; Solid tumours
Details
SIM-201SIM-201; SIM-0201Phase 1 ClinicalJiangsu Simcere Pharmaceutical Co Ltd
Solid tumours
Details
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