PD-L2 Overview
Molecule Name
Programmed death-ligand 2
Synonyms
PDL2,PD-L2,Butyrophilin B7-DC,CD273,PDCD1 ligand 2,PDCD1L2,PDCD1LG2
Drug Development Progress
Drugs in Clinical Trials3
Approved Drugs0
Highest Development StagePhase 3 Clinical
Target Synonym
PDCD1LG2，PDL2，Programmed death ligand 2，CD273，Butyrophilin B7-DC，PD-1 ligand 2，B7-DC，BA574F11.2，PDCD1L2，CD273 Antigen，B7DC，Btdc，B7 Dendritic Cell Molecule，PD-1-Ligand 2，PDCD1 ligand 2，Programmed cell death 1 ligand 2
Background
Programmed cell death 1 ligand 2 (PD-L2 or PDCD1 ligand 2) is also known as Butyrophilin B7-DC, CD antigen CD273, which belongs to the immunoglobulin superfamily or BTN/MOG family. The expression of PD-L2 is up-regulated by IFNG/IFN-gamma stimulation in monocytes and induced on dendritic cells grown from peripheral blood mononuclear cells with CSF2 and IL-4. PD-L2 Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. PD-L2 interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.
PD-L2 Product List
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1***32019-10-11ACROBiosystem's proteins have high purity. They totally meet our requirements. Most importantly, repeatability among batches is very good, and the quality control is great. Thank you!- 1***22019-10-12I purchased the PD-L2 protein for ELISA related experiments. Coating the protein into a well plate, and then adding antibody molecules to incubate with biotin-PD1. I could obtain good stable and repeatable data.