Osteoactivin

Osteoactivin Overview

English Name	Transmembrane glycoprotein NMB	Approved Drugs	0
Drugs in Clinical Trials	2	Target Synonym	Transmembrane Glycoprotein，HGFIN，Transmembrane glycoprotein NMB，Hematopoietic growth factor inducible neurokinin-1 type，GPNMB，Glycoprotein Nmb，Hematopoietic Growth Factor Inducible Neurokinin-1，Glycoprotein Nonmetastatic Melanoma Protein B，Transmembrane Glycoprotein HGFIN，Glycoprotein (Transmembrane) Nmb，Glycoprotein Nmb-Like Protein，Osteoactivin，PLCA3，NMB，UNQ1725/PRO9925
Highest Development Stage	Phase 2 Clinical

English Name	Transmembrane glycoprotein NMB
Target Synonym	Transmembrane Glycoprotein，HGFIN，Transmembrane glycoprotein NMB，Hematopoietic growth factor inducible neurokinin-1 type，GPNMB，Glycoprotein Nmb，Hematopoietic Growth Factor Inducible Neurokinin-1，Glycoprotein Nonmetastatic Melanoma Protein B，Transmembrane Glycoprotein HGFIN，Glycoprotein (Transmembrane) Nmb，Glycoprotein Nmb-Like Protein，Osteoactivin，PLCA3，NMB，UNQ1725/PRO9925
Approved Drugs	0
Drugs in Clinical Trials	2
Highest Development Stage	Phase 2 Clinical

Osteoactivin Product List

Product Category
Protein (1)
Product Status
Launched (1)
Species
Human (1)
Tag
His Tag (1)
Conjugate
Unconjugated (1)

Cat. No.	Species	Host	Product Description	Structure	Purity	Feature	Order Now
GPB-H5229	Human	HEK293	Human Osteoactivin / GPNMB Protein, His Tag, low endotoxin				Add to Cart

Total: 1

Osteoactivin Background

Transmembrane glycoprotein NMB (GPNMB) is also known as Transmembrane glycoprotein HGFIN, DC-HIL and Osteoactivin (OA), which belongs to the PMEL/NMB family. GPNMB contains one PKD domain. GPNMB is a transmembrane glycoprotein that is up-regulated in various cancer cells, including in glioblastoma multiforme and is expressed in many melanoma cells, as well as in tissue macrophages. GPNMB protein acts as a downstream mediator of BMP-2 effects on osteoblast differentiation and function. GPNMB participates in bone mineralization, and functions as a negative regulator of inflammation in macrophages.

Osteoactivin Synonyms

GPNMB,HGFIN,NMB,Osteoactivin

Clinical Drug Information

English Name	Research Code	Highest Development Stage	Company	Indication	Clinical Trial
Glembatumumab vedotin	CR-011; CDX-011; CR-011-ADC; CR011-vcMMAE	Phase 2 Clinical	Celldex Therapeutics	Breast Neoplasms; Carcinoma, Squamous Cell; Melanoma; Osteosarcoma; Skin Melanoma; Solid tumours; Triple Negative Breast Neoplasms; Uveal melanoma	Details
GPNMB-targeting Chimeric Antigen Receptor T-Cell Therapy (AHS Cancer Control Alberta)	GCAR1	Phase 1 Clinical	AHS Cancer Control Alberta	Carcinoma, Renal Cell; Sarcoma; Sarcoma, Alveolar Soft Part; Triple Negative Breast Neoplasms	Details

Product Reviews

A***c2026-02-27
0People Like
Human Osteoactivin / GPNMB Protein, His Tag, low endotoxin
The Human Osteoactivin / GPNMB Protein, His Tag I purchased has been a reliable and useful reagent for interference testing. This reagent was optimal for work in both a PK and ADA assay. There have been no observed lot to lot differences, which is important in my line of work. I would recommend this product.