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Nectin-2

Nectin-2 Product List

Product Category
Protein (6)
Product Status
Launched (6)
Species
Human (6)
Tag
His Tag (1)Fc Tag (1)Fc Tag & Avi Tag (1)Mouse IgG Fc Tag (1)Mouse IgG Fc Tag & Avi Tag (1)His Tag & Avi Tag (1)
Conjugate
Unconjugated (3)Biotin-labeled (3)

Cat. No.	Species	Host	Product Description
HOT CD2-H82E7	Human	HEK293	Biotinylated Human Nectin-2 / CD112 Protein, His,Avitag™ (MALS verified)
HOT CD2-H82F8	Human	HEK293	Biotinylated Human Nectin-2 / CD112 Protein, Fc,Avitag™ (MALS verified)
HOT PV2-H5253	Human	HEK293	Human Nectin-2 / CD112 Protein, Fc Tag
HOT PV2-H52E2	Human	HEK293	Human Nectin-2 / CD112 Protein, His Tag, low endotoxin (MALS verified)
CD2-H5257	Human	HEK293	Human Nectin-2 / CD112 Protein, Mouse IgG2a Fc Tag
CD2-H82A3	Human	HEK293	Biotinylated Human Nectin-2 / CD112 Protein, Mouse IgG2a Fc,Avitag™ (MALS verified)

Total: 6

Nectin-2 Background

Poliovirus receptor-related 2 (PVRL2) is also known as nectin-2 and CD112 (formerly herpesvirus entry mediator B, HVEB), which is a human plasma membrane glycoprotein. PVRL2 is one of the plasma membrane components of adherens junctions. PVRL2 also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in PVRL2 gene have been associated with differences in the severity of multiple sclerosis. Also, PVRL2 binds with low affinity to TIGIT. Furthermore, PVRL2 acts as a receptor for herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV).

Clinical Drug Information

English Name	Research Code	Highest Development Stage	Company	Indication	Clinical Trial
COM-701	COM-701	Phase 2 Clinical	Compugen Ltd	Solid tumours; Head and Neck Neoplasms; Ovarian Neoplasms; Triple Negative Breast Neoplasms; Neoplasms; Breast Neoplasms; Colorectal Neoplasms; Endometrial Neoplasms; Lung Neoplasms	Details
PM-1009	PM1009	Phase 2 Clinical		Liver Neoplasms; Solid tumours; Neoplasms; Lung Neoplasms; Carcinoma, Hepatocellular	Details
SIM-0348	SIM-0348	Phase 1 Clinical	Simcere Pharmaceutical Group Ltd	Solid tumours; Neoplasms	Details
GSK-4381562	SRF-813; GSK-4381562; GSK-4381562A; GSK4381562A; GSK’562	Phase 1 Clinical	Surface Oncology Inc	Solid tumours; Neoplasms	Details
NM1F	NM1F; TGI-2	Phase 1 Clinical	Hefei TG ImmunoPharma Co Ltd	Ovarian Neoplasms; Solid tumours; Triple Negative Breast Neoplasms; Colorectal Neoplasms; Melanoma	Details
SHR-2002	SHR-2002	Phase 1 Clinical	Suzhou Suncadia Biopharmaceuticals Co Ltd, Shanghai Hengrui Pharmaceutical Co Ltd	Neoplasms	Details
JS-009	JS009; TAB009; JS-009	Phase 1 Clinical	Shanghai Junshi Biosciences Co Ltd	Solid tumours; Neoplasms	Details