MBL

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MBL Overview

Molecule Name

Mannose-binding protein C

Synonyms

MBL,MBL2,MBP1,MBP-C,Collectin-1,COLEC1,HSMBPC,MBL2D,MBPD

Drug Development Progress

Drugs in Clinical Trials1

Approved Drugs0

Highest Development StageClinical

Target Synonym

Mannose Binding Lectin 2，Mannose-Binding Lectin (Protein C) 2， Soluble (Opsonic Defect)，MBL，Mannose-Binding Lectin 2， Soluble (Opsonic Defect)，Mannose-Binding Lectin (Protein C) 2， Soluble，Mannan-Binding Protein，Mannan-Binding Lectin，HSMBPC，MBL2D，MBPD，MBP，Mannose-Binding Lectins，Mannose-Binding Protein，MBP1，COLEC1，Mannose-binding protein C，Mannose-binding lectin，Collectin-1，MBP-C，MBL2

Background

Mannose-binding lectin (MBL) is also known as mannose-binding protein, mannan-binding protein (MBP), Mannose-binding protein C, Collectin-1 (COLEC1), MBL2, which belongs to the class of collectins in the C-type lectin superfamily. MBL contains one C-type lectin domain and one collagen-like domain. MBL has an oligomeric structure (400-700 kDa), built of subunits that contain three presumably identical peptide chains of about 30 kDa each. MBL is calcium-dependent lectin involved in innate immune defense. MBL binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. MBL binds to late apoptotic cells. MBL may bind DNA.