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Home PageAll MoleculesKlotho beta
Klotho beta
Klotho beta Overview
| English Name | Klotho beta | Approved Drugs | 0 |
| Drugs in Clinical Trials | 3 | Target Synonym | Klotho Beta，Klotho Beta-Like Protein，B-Klotho，Klotho Beta Like，Beta-Klotho，EC 3.2.1，BKL，BetaKlotho，KLB |
| Highest Development Stage | Phase 2 Clinical | ||
| English Name | Klotho beta |
| Target Synonym | Klotho Beta，Klotho Beta-Like Protein，B-Klotho，Klotho Beta Like，Beta-Klotho，EC 3.2.1，BKL，BetaKlotho，KLB |
| Approved Drugs | 0 |
| Drugs in Clinical Trials | 3 |
| Highest Development Stage | Phase 2 Clinical |
Klotho beta Product List
- Product Category
Protein (7)
- Product Status
Launched (7)
- Species
Mouse (2)Cynomolgus / Rhesus macaque (1)Rat (1)Human (2)Rhesus macaque (1)
- Tag
His Tag (7)
- Conjugate
Unconjugated (5)Biotin-labeled (2)
| Cat. No. | Species | Host | Product Description | Structure | Purity | Feature | Order Now |
|---|---|---|---|---|---|---|---|
HOT KLB-H52H4 |  Human | HEK293 | Human Klotho beta / KLB Protein, His Tag |  |  |  |  Add to Cart |
HOT KLB-M52H7 |  Mouse | HEK293 | Mouse Klotho beta / KLB Protein, His Tag |  | |  | Add to Cart |
HOT KLB-R52H8 |  Cynomolgus / Rhesus macaque | HEK293 | Cynomolgus / Rhesus macaque Klotho beta Protein, His Tag |  | | | Add to Cart |
KLB-H82H3 | Human | HEK293 | Biotinylated Human Klotho beta / KLB Protein, His Tag, ultra sensitivity (primary amine labeling) |  | | | Add to Cart |
KLB-M52H3 | Mouse | HEK293 | Biotinylated Mouse Klotho beta / KLB Protein, His Tag, ultra sensitivity (primary amine labeling) (HPLC verified) |  | | Add to Cart | |
KLB-R52H6 |  Rat | HEK293 | Rat Klotho beta / KLB Protein, His Tag |  | | Add to Cart | |
KLB-R82H3 |  Rhesus macaque | HEK293 | Biotinylated Rhesus macaque Klotho beta / KLB Protein, His Tag, ultra sensitivity (primary amine labeling) |  | | | Add to Cart |
Total: 7
- 1
Klotho beta Background
KLB (Klotho Beta) is a Protein Coding gene. Among its related pathways are RET signaling and HIV Life Cycle. GO annotations related to this gene include hydrolase activity, hydrolyzing O-glycosyl compounds and fibroblast growth factor binding. An important paralog of this gene is KL. Klotho Beta is a regulator in multiple metabolic processes, while its role in cancer remains unclear. We found the expression of βKlotho was down-regulated in human hepatocellular carcinoma tissues compared with that in paired adjacent non-tumourous liver tissues. Hepatoma cells also showed decreased expression of βKlotho compared with normal hepatocyte cells. Reintroduction of βKlotho into hepatoma cells inhibited their proliferation.
Klotho beta Synonyms
betaKlotho,beta-klotho,BKL,KLB,klotho beta like,klotho beta-like protein
Clinical Drug Information
| English Name | Research Code | Highest Development Stage | Company | Indication | Clinical Trial |
|---|---|---|---|---|---|
| NGM-313 | NGM-313; MK-3655 | Phase 2 Clinical | NGM Biopharmaceuticals Inc | Hepatitis; Metabolic Dysfunction-Associated Steatotic Liver Disease; Obesity | Details |
| JMT-202 | JMT202; JMT-202 | Phase 2 Clinical | Shanghai Jmt-Bio Inc | Hypertriglyceridemia | Details |
| DR-10624 | DR-10624; DR10624 | Phase 2 Clinical | Zhejiang Doer Biologics Corp | Diabetes Mellitus; Diabetes Mellitus, Type 2; Hypertriglyceridemia; Metabolic Dysfunction-Associated Steatotic Liver Disease; Metabolic Syndrome; Obesity; Overweight | Details |
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