user
menu
letter
Sign InRegister
langEnglisharrow

Integrin alpha M beta 2

Integrin alpha M beta 2

Integrin alpha M beta 2 Overview

Molecule Name
Integrin alpha-M/beta-2
Synonyms
Integrin alpha M beta 2,ITGAM&ITGB2
Drug Development Progress
Drugs in Clinical Trials0
Approved Drugs0
Highest Development StageDiscontinued
Target Synonym
Macrophage-1 Antigen
Background
Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils. May regulate phagocytosis-induced apoptosis in extravasated neutrophils. May play a role in mast cell development. Required with TYROBP/DAP12 in microglia to control production of microglial superoxide ions which promote the neuronal apoptosis that occurs during brain development.

Integrin alpha M beta 2 Product List

Species
  • Human（1）
Tag
  • His Tag（1）
Host
  • CHO（1）
Conjugate
  • Unconjugated（1）
Grade
  • RUO（1）
Low Endotoxin
  • Yes（1）
MoleculeCat. No.Product NameSpeciesHostStructurePurityActivitySize&Price
Integrin alpha M beta 2
AIDD‑Ready
IT2-H52W4
Human Integrin alpha M beta 2 (ITGAM&ITGB2) Heterodimer Protein, His Tag&Tag Free, low endotoxin (MALS verified)
Human
CHO
MALSSDS-PAGE
SPR

$485.00

100ug
You Have Viewed 1-1 Of 1 Results
  • 1

Can’t find what you need?

Submit your requirements and our technical
team will help.

Product InquiryRequest Customization