IL-8 Overview
Molecule Name
Interleukin-8
Synonyms
CXCL8,GCP1,IL8,LECT,LUCT,LYNAP,MDNCF,MONAP,NAF,NAP-1
Drug Development Progress
Drugs in Clinical Trials6
Approved Drugs1
Highest Development StageApproved
Target Synonym
IL8/NAP1 form VI，T-cell chemotactic factor，GCP/IL-8 protein III，IL8/NAP1 form II，GCP/IL-8 protein II，(Ala-IL-8)77，Emoctakin，IL8/NAP1 form IV，LYNAP，IL8/NAP1 form III，IL8/NAP1 form V，GCP/IL-8 protein I，Neutrophil-Activating Peptide 1，Interleukin 8，GCP-1，MDNCF，NAP-1，IL8，Beta Endothelial Cell-Derived Neutrophil Activating Peptide，Lung Giant Cell Carcinoma-Derived Chemotactic Protein，Lymphocyte Derived Neutrophil Activating Peptide，Alveolar Macrophage Chemotactic Factor I，Tumor Necrosis Factor-Induced Gene 1，Small Inducible Cytokine Subfamily B， Member 8，Beta-Thromboglobulin-Like Protein，GCP1，LECT，LUCT，NAP1，IL-8，Interleukin-8，AMCF-I，SCYB8，Neutrophil-Activating Protein 1，B-ENAP，3-10C，K60，TSG-1，C-X-C Motif Chemokine Ligand 8，Monocyte-Derived Neutrophil Chemotactic Factor，Monocyte-Derived Neutrophil-Activating Peptide，Granulocyte Chemotactic Protein 1，Chemokine (C-X-C Motif) Ligand 8，(Ser-IL-8)72，Neutrophil-activating factor，MDNCF-c，C-X-C motif chemokine 8，Lymphocyte-derived neutrophil-activating factor，Protein 3-10C，IL-8(1-77)，NAF，GCP/IL-8 protein VI，GCP/IL-8 protein IV，IL8/NAP1 form I，MONAP，MDNCF-b，GCP/IL-8 protein V，CXCL8
Background
Interleukin 8 (IL8 or chemokine (C-X-C motif) ligand 8, CXCL8) is a chemokine produced by macrophages and other cell types such as epithelial cells, airway smooth muscle cells and endothelial cells. There are many receptors on the surface membrane capable of binding IL-8, the most frequently studied types are the G protein-coupled serpentine receptors CXCR1 and CXCR2. Expression and affinity for IL-8 differs between the two receptors (CXCR1 > CXCR2). IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively.
IL-8 Product List
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Clinical Drug Information
| English Name | Research Code | Highest Development Stage | Company | Indication | Clinical Trial |
|---|---|---|---|---|---|
| Ensereptide | PXL-01 | Phase 3 Clinical | Promore Pharma | Cicatrix; Post-surgical adhesions; Tissue Adhesions | Details |
| Cinainu | Phase 3 Clinical | Legacy Healthcare (Switzerland) Sa | Alopecia Areata | Details | |
| Sodium Hypochlorite | Phase 3 Clinical | Cystic Fibrosis; Dental Pulp Necrosis; Fibrosis; Infections; Pain; Pain, Postoperative; Pulpitis | Details | ||
| Adakitug | BMS-986253; MDX-018 | Phase 2 Clinical | Bristol-Myers Squibb Company, Genmab A/S, Medarex Inc | Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Coronavirus Disease 2019 (COVID-19); Hematologic Neoplasms; Melanoma; Myelodysplastic Syndromes; Neoplasms; Prostatic Neoplasms; Solid tumours; Squamous Cell Carcinoma of Head and Neck | Details |
| AMY-109 | AMY-109; AMY109 | Phase 2 Clinical | Chugai Pharmaceutical Co Ltd | Endometriosis; Solid tumours | Details |
| AC-701 | AC-701 | Phase 2 Clinical | Twi Pharmaceuticals Inc | Exanthema; Rosacea | Details |
Marketed Drug Information
| English Name | Research Code | Highest Development Stage | Company | Earliest Brand Name | Earliest Approval Country | Earliest Indication | Earliest Approval Company | Earliest Approval Date | Indication | Clinical Trial |
|---|---|---|---|---|---|---|---|---|---|---|
| Mouse monoclonal antibody against human interleukin-8 cream | Approved | Dalian Asia Space Pharmaceutical Co Ltd, Dongguan Hongyuan Yishi Biotechnology Pharmaceutical Co Ltd | 恩博克 | Mainland China | Eczema; Psoriasis | Dalian Asia Space Pharmaceutical Co Ltd | 2001-04-10 | Eczema; Psoriasis | Details |