IL-5 R alpha

IL-5 R alpha Overview

English Name	Interleukin-5 receptor subunit alpha	Approved Drugs	1
Drugs in Clinical Trials	2	Target Synonym	Interleukin 5 Receptor， Alpha，Interleukin-5 Receptor Subunit Alpha，HSIL5R3，Interleukin-5 Receptor Alpha Chain，CDw125，Interleukin-5 Receptor alpha Subunit，Interleukin 5 Receptor Type 3，CD125 Antigen，Interleukin 5 Receptor Subunit Alpha，IL-5 Receptor Subunit Alpha，IL-5R-Alpha，IL5R，IL5RA，CD125，IL-5RA，IL-5R Subunit Alpha
Highest Development Stage	Approved

English Name	Interleukin-5 receptor subunit alpha
Target Synonym	Interleukin 5 Receptor， Alpha，Interleukin-5 Receptor Subunit Alpha，HSIL5R3，Interleukin-5 Receptor Alpha Chain，CDw125，Interleukin-5 Receptor alpha Subunit，Interleukin 5 Receptor Type 3，CD125 Antigen，Interleukin 5 Receptor Subunit Alpha，IL-5 Receptor Subunit Alpha，IL-5R-Alpha，IL5R，IL5RA，CD125，IL-5RA，IL-5R Subunit Alpha
Approved Drugs	1
Drugs in Clinical Trials	2
Highest Development Stage	Approved

IL-5 R alpha Product List

Product Category
Protein (4)
Product Status
Launched (4)
Species
Human (3)Mouse (1)
Tag
His Tag (2)Fc Tag (1)Avi Tag & Fc Tag (1)
Conjugate
Unconjugated (3)Biotin-labeled (1)

Cat. No.	Species	Host	Product Description	Order Now
ILA-H5269	Human	HEK293	Human IL-5 R alpha / CD125 Protein, Fc Tag (MALS verified)	Add to Cart
ILA-H52H4	Human	HEK293	Human IL-5 R alpha / CD125 Protein, His Tag, low endotoxin (MALS verified)	Add to Cart
ILA-H82F5	Human	HEK293	Biotinylated Human IL-5 R alpha / CD125 Protein, Avitag™,Fc Tag (MALS verified)	Add to Cart
ILA-M52H7	Mouse	HEK293	Mouse IL-5 R alpha / CD125 Protein, His Tag (MALS & SPR verified)	Add to Cart

Total: 4

IL-5 R alpha Background

Interleukin-5 receptor subunit alpha (IL5RA) is also known as IL-5 receptor subunit alpha, IL-5R subunit alpha and CD125,which is a single-pass type I membrane protein that belongs to the type I cytokine receptor family and type 5 subfamily.IL5R, a heterodimer of an alpha and a beta subunit, is expressed on eosinophils and basophils. IL5RA / CD125 is the receptor for interleukin-5 (IL5) and the alpha chain can bind to IL5. The WSXWS motif of IL5RA appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.The beta subunit of IL5R is common to the IL3, IL5 and GM-CSF receptors.

IL-5 R alpha Synonyms

IL5Ra,CD125

Clinical Drug Information

English Name	Research Code	Highest Development Stage	Company	Indication	Clinical Trial
IL-5 CAR-T Cell Therapy (Zhejiang University)		Phase 1 Clinical	Zhejiang University	Hematologic Diseases; Neoplasms	Details
Trabikibart	CSL-311	Phase 1 Clinical	Csl Ltd	Asthma	Details

Marketed Drug Information

English Name	Research Code	Highest Development Stage	Company	Earliest Brand Name	Earliest Approval Country	Earliest Indication	Earliest Approval Company	Earliest Approval Date	Indication	Clinical Trial
Benralizumab	KHK-4563; MEDI-563; BIW-8405; BIW-8405-IL-5R	Approved	Biowa Inc, Medimmune Llc	Fasenra, 凡舒卓	United States	Asthma	Astrazeneca Ab	2017-11-14	Asthma; Asthma, Exercise-Induced; Bronchiectasis; Chronic Urticaria; Dermatitis; Dermatitis, Atopic; Drug Hypersensitivity Syndrome; Eczema; Eosinophilia; Eosinophilic Asthma; Eosinophilic Esophagitis; Eosinophilic gastroenteritis (EG); Eosinophilic Granulomatosis With Polyangiitis; Gastroenteritis; Genetic Diseases, Inborn; Granulomatosis with Polyangiitis; Hematologic Diseases; Hypereosinophilic Syndrome; Hypersensitivity; Hypersensitivity, Immediate; Immune System Diseases; Leukocyte Disorders; Nasal Polyps; Pemphigoid, Bullous; Pulmonary Disease, Chronic Obstructive; Respiratory Tract Diseases; Sinusitis; Skin Diseases; Skin Diseases, Eczematous; Skin Diseases, Genetic	Details