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IL-4
IL-4 Overview
| English Name | Interleukin-4 | Approved Drugs | 2 |
| Drugs in Clinical Trials | 14 | Target Synonym | MGC79402，B-cell stimulatory factor 1，Lymphocyte stimulatory factor 1，IL4，Interleukin 4，B_cell Stimulatory Factor 1，B Cell Growth Factor 1，Binetrakin，Pitrakinra，BSF-1，IL-4，Interleukin 4 Variant 2，BCGF-1，BCGF1，BSF1，Interleukin-4 |
| Highest Development Stage | Approved | ||
| English Name | Interleukin-4 |
| Target Synonym | MGC79402，B-cell stimulatory factor 1，Lymphocyte stimulatory factor 1，IL4，Interleukin 4，B_cell Stimulatory Factor 1，B Cell Growth Factor 1，Binetrakin，Pitrakinra，BSF-1，IL-4，Interleukin 4 Variant 2，BCGF-1，BCGF1，BSF1，Interleukin-4 |
| Approved Drugs | 2 |
| Drugs in Clinical Trials | 14 |
| Highest Development Stage | Approved |
IL-4 Product List
- Product Category
Protein (12)Kits (5)
- Product Status
Launched (15)In Research (2)
- Species
Human (10)Mouse (3)Cynomolgus (3)Rabbit (1)
- Tag
Tag Free (3)His Tag & Avi Tag (3)His Tag (4)Fc Tag (2)- (5)
- Conjugate
Unconjugated (9)Biotin-labeled (3)- (5)
| Cat. No. | Species | Host | Product Description | Structure | Purity | Feature | Order Now |
|---|---|---|---|---|---|---|---|
HOT GMP-L04H26 |  Human | HEK293 | GMP Human IL-4 Protein |  |  |  |  Add to Cart |
HOT IL4-H4218 | Human | HEK293 | Human IL-4 Protein, premium grade |  | |  | Add to Cart |
HOT IL4-H5253 | Human | HEK293 | Human IL-4 Protein, Fc Tag, low endotoxin (MALS verified) |  | | | Add to Cart |
HOT IL4-H52H9 | Human | HEK293 | Human IL-4 Protein, His Tag, low endotoxin (MALS verified) |  | | | Add to Cart |
HOT IL4-H82E0 | Human | HEK293 | Biotinylated Human IL-4 Protein, Avitag™,His Tag (MALS verified) |  | | | Add to Cart |
CRS-A004 | Human | - | resDetect™ Human Interleukin-4 (IL-4) ELISA Kit (Residue Testing) | Add to Cart | |||
CRS-B003 | Human | - | Human IL-4 ELISA Kit | Add to Cart | |||
EP-132 | Human | - | IL-4 [Biotinylated] : IL-4Rα Inhibitor Screening ELISA Kit | Add to Cart | |||
FCSh-002 | Human | - | Human IL-4 Detection Kit (Flow Cytometry Bead Assay) | Pre-order | |||
IL4-H5219 | Human | HEK293 | Human IL-4 Protein, Research Grade |  | | | Add to Cart |
Total: 17
- 1
- 2
IL-4 Background
Interleukin-4, is a cytokine that induces differentiation of naive helper T cells (Th0 cells to Th2 cells). In the presence of IL-4 and IL-13, cytokines that are produced in a Th-2 type response, particularly during allergy and parasitic infections, macrophages become differentially activated, And this cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. Recently, researcher found that the cytokine IL-4 plays a key role in development of innate CD8+ T cells in the thymus of several gene-deficient mouse strains, including Itk, KLF2, CBP and Id3, without previous exposure to antigen.
IL-4 Synonyms
IL4,BCGF1,BSF1
Clinical Drug Information
| English Name | Research Code | Highest Development Stage | Company | Indication | Clinical Trial |
|---|---|---|---|---|---|
| Dupilumab biosimilar (Jingxing Pharmaceutical) | GS101; GS-101; GS-101 (Jingxing Pharmaceutical) | Phase 3 Clinical | Jiangsu Jingxing Pharmaceutical Technology Co Ltd | Dermatitis, Atopic | Details |
| Dupilumab biosimilar (Qilu Pharma) | QL2108; QL-2108 | Phase 3 Clinical | Qilu Pharmaceutical Co Ltd | Asthma; Dermatitis, Atopic; Prurigo | Details |
| Tilrekimig | PF-07275315 | Phase 3 Clinical | Pfizer Inc | Asthma; Dermatitis, Atopic; Pulmonary Disease, Chronic Obstructive | Details |
| Eblasakimab | MK-6105; ASLAN-004; CSL-334 | Phase 2 Clinical | Csl Ltd, Merck Sharp & Dohme Corp | Dermatitis, Atopic; Hypersensitivity | Details |
| Dectrekumab/VAK-694 | QBX-258 | Phase 2 Clinical | Novartis Pharma Ag | Asthma; Lymphedema | Details |
| OCH-NCNP1 | OCH-NCNP1 | Phase 2 Clinical | Keio University | Crohn Disease; Multiple Sclerosis | Details |
| Ompekimig | PF-07264660 | Phase 2 Clinical | Pfizer Inc | Dermatitis, Atopic | Details |
| AUP1602-C | AUP-16; AUP1602-C | Phase 2 Clinical | Aurealis | Diabetic Foot; Ulcer | Details |
| Dupixent biosimilar (Chong Kun Dang Pharmaceutical) | CKD-706 | Phase 1 Clinical | Chong Kun Dang Pharmaceutical Corp | Dermatitis, Atopic | Details |
| Dupilumab biosimilar (China Resources Biopharma) | Phase 1 Clinical | China Resources Biopharmaceutical Co Ltd | Dermatitis, Atopic | Details | |
| Dupilumab biosimilar (Jiangsu Jingxing Pharma) | Phase 1 Clinical | Jiangsu Jingxing Pharmaceutical Technology Co Ltd | Dermatitis, Atopic | Details | |
| Dupilumab biosimilar (Chengdu Kanghong) | KH-816; KH816 | Phase 1 Clinical | Chengdu Kanghong Biotechnologies Co Ltd | Dermatitis, Atopic | Details |
| Dupilumab biosimilar (Jushi Biopharma) | Phase 1 Clinical | Jushi Biopharmaceutical Co Ltd | Dermatitis, Atopic | Details | |
| Dupilumab biosimilar (Bio-Thera Solutions) | BAT2406; BAT-2406 | Phase 1 Clinical | Bio-Thera Solutions Ltd | Asthma; Dermatitis, Atopic; Eosinophilic Esophagitis; Nasal Polyps; Prurigo Nodularis; Sinusitis | Details |
Marketed Drug Information
| English Name | Research Code | Highest Development Stage | Company | Earliest Brand Name | Earliest Approval Country | Earliest Indication | Earliest Approval Company | Earliest Approval Date | Indication | Clinical Trial |
|---|---|---|---|---|---|---|---|---|---|---|
| Dupilumab | REGN-668; SAR-231893 | Approved | Regeneron Pharmaceuticals Inc, Sanofi | Dupixent, 达必妥 | United States | Dermatitis, Atopic | Regeneron Pharmaceuticals Inc | 2017-03-28 | Allergic Fungal Rhinosinusitis; Alopecia Areata; Angioedema; Aspergillosis, Allergic Bronchopulmonary; Asthma; Asthma, Aspirin-Induced; Chronic Urticaria; Colitis, Ulcerative; Conjunctivitis, Allergic; Coronavirus Disease 2019 (COVID-19); Dermatitis; Dermatitis, Atopic; Eczema; Eosinophilic Esophagitis; Eosinophilic gastroenteritis (EG); Genetic Diseases, Inborn; Hypereosinophilic Syndrome; Hypersensitivity; Hypersensitivity, Immediate; Keloid; Keratoconjunctivitis; Lichenoid Eruptions; Milk Hypersensitivity; Nasal Polyps; Nephrotic Syndrome; Neurodermatitis; Paranasal Sinus Diseases; Peanut Hypersensitivity; Pemphigoid, Bullous; Prostatic Neoplasms; Prurigo; Prurigo Nodularis; Pruritus; Pulmonary Disease, Chronic Obstructive; Respiration Disorders; Respiratory Sounds; Respiratory Tract Diseases; Rhinitis, Allergic; Scleroderma, Localized; Sinusitis; Skin Diseases; Skin Diseases, Eczematous; Sleep Apnea Syndromes; Urticaria | Details |
| Berdazimer sodium | NVN-1000-SB-206-Novan; SB-206; MAP3-NONOate - SB-206; NVN1000-SB206; SB-019; NI-MC101; SB-207; SB-208; SB-204; SB-414 | Approved | University Of North Carolina At Chapel Hill | KINSOLUSTM, Zelsuvmi, ZELSUVMI | United States | Molluscum Contagiosum | Lnhc Inc | 2024-01-05 | Acne Vulgaris; Condylomata Acuminata; Dermatitis, Atopic; Molluscum Contagiosum; Psoriasis; Tinea Pedis | Details |
Product Reviews
M***e2023-06-15
3People LikeWe have used this kit to profile compounds. This kit is both reliable and easy to use, and it shipped quickly. The 96 test kit is also amenable to scaling to a 384 well format for additional screening capabilities. In our experience, the customer service at ACRO has always been prompt when inquiring about when items will be restocked and when they have shipped.
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