IL-31 RA Overview
Molecule Name
Interleukin-31 receptor subunit alpha
Synonyms
IL-31 RA,IL-31RA,hGLM-R,CRL3,GPL,ZcytoR17,GLM-R,IL-31R-alpha,Gp130-like receptor
Drug Development Progress
Drugs in Clinical Trials0
Approved Drugs1
Highest Development StageApproved
Target Synonym
GLM-R，CRL，IL-31R subunit alpha，IL-31 receptor subunit alpha，Cytokine receptor-like 3，Gp130-like monocyte receptor，IL-31RA，ZcytoR17，IL-31R-alpha，PRO21384，GPL，CRL3，GLMR，Interleukin 31 Receptor A，Soluble Type I Cytokine Receptor CRL3，PLCA2，Class I Cytokine Receptor，hGLM-R，Gp130-like receptor
Background
Interleukin-31 receptor subunit alpha is a protein that in humans is encoded by the IL31RA gene, also known as IL-31 receptor subunit alpha, IL-31RA, GLM-R, Gp130-like receptor, CRL3, GPL. Oncostatin M receptor (OSMR) and IL31RA form the heterodimeric receptor through which IL31 signals. IL31RA is a strong activator of STAT3 and STAT5, whereas STAT1 is only marginally tyrosine-phosphorylated. dditionally, demonstrate Jak1 binding to GPL and its activation in heteromeric complexes with the OSMRbeta but also in a homomeric receptor complex.
IL-31 RA Product List
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Marketed Drug Information
| English Name | Research Code | Highest Development Stage | Company | Earliest Brand Name | Earliest Approval Country | Earliest Indication | Earliest Approval Company | Earliest Approval Date | Indication | Clinical Trial |
|---|---|---|---|---|---|---|---|---|---|---|
| Nemolizumab | CD-14152; CIM-331; M 5250; M 5250B | Approved | Chugai Pharmaceutical Co Ltd | Mitchga, Nemluvio | Japan | Dermatitis, Atopic; Pruritus | Maruho Co Ltd | 2022-03-28 | Dermatitis, Atopic; Prurigo; Prurigo Nodularis; Pruritus; Scleroderma, Systemic | Details |